Q66G73 (ARGE_YERPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylornithine deacetylase
Short name=AO
Short name=Acetylornithinase
EC=3.5.1.16

Alternative name(s):
N-acetylornithinase
Short name=NAO

Gene names

Name:	argE
Ordered Locus Names:	YPTB0109

Organism

Yersinia pseudotuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

633 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine. HAMAP MF_01108
Cofactor	Binds 2 zinc or cobalt ions per subunit By similarity. HAMAP MF_01108 Glutathione By similarity. HAMAP MF_01108
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1. HAMAP MF_01108
Subunit structure	Homodimer By similarity. HAMAP MF_01108
Subcellular location	Cytoplasm Probable HAMAP MF_01108.
Sequence similarities	Belongs to the peptidase M20A family. ArgE subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	Cobalt Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetylornithine deacetylase activity Inferred from electronic annotation. Source: EC cobalt ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Acetylornithine deacetylase HAMAP MF_01108		PRO_1000065068
Sites
	Active site	87	1	By similarity
	Active site	149	1	By similarity
	Metal binding	85	1	Cobalt or zinc 1 By similarity
	Metal binding	117	1	Cobalt or zinc 1 By similarity
	Metal binding	117	1	Cobalt or zinc 2 By similarity
	Metal binding	150	1	Cobalt or zinc 2 By similarity
	Metal binding	174	1	Cobalt or zinc 1 By similarity
	Metal binding	360	1	Cobalt or zinc 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q66G73 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: AF6E66533CE62038	FASTA	389	42,950
	10 20 30 40 50 60 MKMKLPPFIE LYRALIATPS ISAADSALDQ SNEALINLLA GWFADLGFRV EIQPVPDTRH 70 80 90 100 110 120 KFNLLASIGE NENGEGHGGL LLAGHTDTVP YDEGRWTRDP FTLTEHDHKL YGLGTADMKG 130 140 150 160 170 180 FFAFILDAVR DIDASKLTKP LYILATADEE TTMAGARYFA ANTQLRPDFA IIGEPTSLQP 190 200 210 220 230 240 VRAHKGHISN AIRITGQSGH SSDPARGVNA IDLMHESITQ LMALRTTLQE RYHNPAFTIP 250 260 270 280 290 300 YPTMNFGHIN GGDAANRICA CCELHMDIRP LPGLTLSDLN ELMTEALEPV SQRWPGRLSI 310 320 330 340 350 360 DELHPPIPGY ECPTDHHMVG VIEKLLGERT AVVNYCTEAP FIQQVCPTLV LGPGSINQAH 370 380 QPDEFIDMAF IEPTRELIGQ LVDHFCQQK

References

[1]

"Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis." Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O., Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L., Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C., Simonet M., Chenal-Francisque V., Souza B. , Dacheux D., Elliott J.M., Derbise A., Hauser L.J., Garcia E. Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004) [PubMed: 15358858] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IP32953 / Serotype I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX936398 Genomic DNA. Translation: CAH19349.1.
RefSeq	YP_068658.1. NC_006155.1.
3D structure databases
ProteinModelPortal	Q66G73.
ModBase	Search...
Protein family/group databases
MEROPS	M20.974.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2955215.
GenomeReviews	Gene locus YPTB0109 in contig BX936398_GR.
KEGG	yps:YPTB0109.
PATRIC	18638274. VBIYerPse22266_0260.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG728841.
OMA	DIACAHQ.
ProtClustDB	PRK05111.
Enzyme and pathway databases
BioCyc	YPSE273123:YPTB0109-MONOMER.
Family and domain databases
HAMAP	MF_01108. ArgE. [Tree]
InterPro	IPR010169. AcOrn-deacetyl. IPR001261. ArgE/DapE_CS. IPR002933. Peptidase_M20. IPR011650. Peptidase_M20_dimer. [Graphical view]
KO	K01438.
Pfam	PF07687. M20_dimer. 1 hit. PF01546. Peptidase_M20. 1 hit. [Graphical view]
SUPFAM	SSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMs	TIGR01892. AcOrn-deacetyl. 1 hit.
PROSITE	PS00758. ARGE_DAPE_CPG2_1. 1 hit. PS00759. ARGE_DAPE_CPG2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGE_YERPS

Accession

Primary (citable) accession number: Q66G73

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program