Q66EW0 (DEOC2_YERPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase 2
Short name=DERA 2
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase 2
Phosphodeoxyriboaldolase 2
Short name=Deoxyriboaldolase 2

Gene names

Name:	deoC2
Ordered Locus Names:	YPTB0581

Organism

Yersinia pseudotuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

633 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00592
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00592
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00592
Subcellular location	Cytoplasm By similarity HAMAP MF_00592.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Deoxyribose-phosphate aldolase 2 HAMAP MF_00592		PRO_0000231576
Sites
	Active site	173	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	207	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q66EW0 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 353149B5782AEB14	FASTA	265	28,274
	10 20 30 40 50 60 MTDLTACAHL NDYAKRALSL MDLTTLNDDD TDEKVIALCH QAKSPAGNTA AICIYPRFIP 70 80 90 100 110 120 VARKALREQG TPEIRIATVT NFPHGNDDVA IALAETRAAI AYGADEVDVV FPYRALMAGN 130 140 150 160 170 180 DKIGFELVKT CKEACAAANV LLKVIIETGE LKQAHLIRQA SEIAIKAGAD FIKTSTGKVP 190 200 210 220 230 240 VNATLESADI MIRTIRELGV GETVGFKPAG GVRTAEDAAQ FLQLADQLMG EGWADARHFR 250 260 FGASSLLASL LTTLGHQSNA NSSGY

References

[1]

"Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis." Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O., Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L., Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C., Simonet M., Chenal-Francisque V., Souza B. , Dacheux D., Elliott J.M., Derbise A., Hauser L.J., Garcia E. Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004) [PubMed: 15358858] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IP32953 / Serotype I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX936398 Genomic DNA. Translation: CAH19821.1.
RefSeq	YP_069123.1. NC_006155.1.
3D structure databases
ProteinModelPortal	Q66EW0.
SMR	Q66EW0. Positions 1-256.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2955452.
GenomeReviews	Gene locus YPTB0581 in contig BX936398_GR.
KEGG	yps:YPTB0581.
PATRIC	18639396. VBIYerPse22266_0789.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG636421.
OMA	FELVKQC.
ProtClustDB	PRK05283.
Enzyme and pathway databases
BioCyc	YPSE273123:YPTB0581-MONOMER.
Family and domain databases
HAMAP	MF_00592. DeoC_type2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR023649. DeoC_bac. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC2_YERPS

Accession

Primary (citable) accession number: Q66EW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program