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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-797-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodCImported
Ordered Locus Names:YPTB0756Imported
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)Imported
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001011: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 PotentialImportedAdd
BLAST
Chaini21 – 189169 PotentialImportedPRO_5000098466Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273123.YPTB0756.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WWNX-ray2.60A/B21-189[»]
2WWOX-ray2.40A/B21-189[»]
ProteinModelPortaliQ66ED7.
SMRiQ66ED7. Positions 36-189.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ66ED7.

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalImported

Phylogenomic databases

HOGENOMiHOG000263449.
KOiK04565.
OMAiGKCEPPF.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66ED7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSTLLLPV ILYSSATLAA NMAGMNDKAS MNDKASMTVK INESLPQGNG
60 70 80 90 100
KALGTVTVTE TAYGLLFTPH LTGLAPGIHG FHLHEKPSCA PGMKDGKAVP
110 120 130 140 150
ALAAGGHLDP NKTGVHLGPY NDKGHLGDLP GLVVNADGTA TYPVLAPRLK
160 170 180
SLSEVKQHAL MIHAGGDNYS DHPMPLGGGG ARMACGVIE
Length:189
Mass (Da):19,436
Last modified:October 11, 2004 - v1
Checksum:i9E996703B09163E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936398 Genomic DNA. Translation: CAH19996.1.
RefSeqiWP_011191771.1. NC_006155.1.
YP_069297.1. NC_006155.1.

Genome annotation databases

EnsemblBacteriaiCAH19996; CAH19996; YPTB0756.
GeneIDi2956620.
KEGGiyps:YPTB0756.
PATRICi18639806. VBIYerPse22266_0996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936398 Genomic DNA. Translation: CAH19996.1.
RefSeqiWP_011191771.1. NC_006155.1.
YP_069297.1. NC_006155.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WWNX-ray2.60A/B21-189[»]
2WWOX-ray2.40A/B21-189[»]
ProteinModelPortaliQ66ED7.
SMRiQ66ED7. Positions 36-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273123.YPTB0756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH19996; CAH19996; YPTB0756.
GeneIDi2956620.
KEGGiyps:YPTB0756.
PATRICi18639806. VBIYerPse22266_0996.

Phylogenomic databases

HOGENOMiHOG000263449.
KOiK04565.
OMAiGKCEPPF.
OrthoDBiEOG6K13RS.

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-797-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ66ED7.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP32953Imported.
  2. "Crystal Structure of the Yersinia Pseudotuberculosis Superoxide Dismutase (Sodc)."
    Huyet J., Naylor C.E., Titball R.W., Bullifent H., Walker N., Jones H.E., Duffied M.L., Basak A.K.
    Submitted (OCT-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 21-189 IN COMPLEX WITH ZINC, ACTIVE SITE.

Entry informationi

Entry nameiQ66ED7_YERPS
AccessioniPrimary (citable) accession number: Q66ED7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 4, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.