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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26Zinc 1Combined sources1
Metal bindingi27Zinc 1Combined sources1
Metal bindingi82Zinc 2; via pros nitrogenCombined sources1
Metal bindingi84Zinc 2; via tele nitrogenCombined sources1
Metal bindingi107Zinc 2; via tele nitrogenCombined sources1
Metal bindingi107Zinc 3; via pros nitrogenCombined sources1
Metal bindingi116Zinc 3; via pros nitrogenCombined sources1
Metal bindingi125Zinc 3; via pros nitrogenCombined sources1
Metal bindingi128Zinc 3Combined sources1
Metal bindingi163Zinc 2; via tele nitrogenCombined sources1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotationCombined sources, ZincUniRule annotationCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sodCImported
Ordered Locus Names:YPTB0756Imported
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)Imported
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000001011 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500426896320 – 189Superoxide dismutase [Cu-Zn]Sequence analysisAdd BLAST170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 185Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WWNX-ray2.60A/B21-189[»]
2WWOX-ray2.40A/B21-189[»]
ProteinModelPortaliQ66ED7.
SMRiQ66ED7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 188Sod_CuInterPro annotationAdd BLAST141

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000263449.
KOiK04565.
OMAiDKAGMND.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66ED7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSTLLLPV ILYSSATLAA NMAGMNDKAS MNDKASMTVK INESLPQGNG
60 70 80 90 100
KALGTVTVTE TAYGLLFTPH LTGLAPGIHG FHLHEKPSCA PGMKDGKAVP
110 120 130 140 150
ALAAGGHLDP NKTGVHLGPY NDKGHLGDLP GLVVNADGTA TYPVLAPRLK
160 170 180
SLSEVKQHAL MIHAGGDNYS DHPMPLGGGG ARMACGVIE
Length:189
Mass (Da):19,436
Last modified:October 11, 2004 - v1
Checksum:i9E996703B09163E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936398 Genomic DNA. Translation: CAH19996.1.
RefSeqiWP_011191771.1. NZ_CP009712.1.

Genome annotation databases

EnsemblBacteriaiCAH19996; CAH19996; YPTB0756.
KEGGiypo:BZ17_1800.
yps:YPTB0756.
PATRICi18639806. VBIYerPse22266_0996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936398 Genomic DNA. Translation: CAH19996.1.
RefSeqiWP_011191771.1. NZ_CP009712.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WWNX-ray2.60A/B21-189[»]
2WWOX-ray2.40A/B21-189[»]
ProteinModelPortaliQ66ED7.
SMRiQ66ED7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH19996; CAH19996; YPTB0756.
KEGGiypo:BZ17_1800.
yps:YPTB0756.
PATRICi18639806. VBIYerPse22266_0996.

Phylogenomic databases

HOGENOMiHOG000263449.
KOiK04565.
OMAiDKAGMND.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ66ED7_YERPS
AccessioniPrimary (citable) accession number: Q66ED7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.