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Q66DA9

- NADK_YERPS

UniProt

Q66DA9 - NADK_YERPS

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Protein

NAD kinase

Gene

nadK

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei74 – 741Proton acceptorUniRule annotation
Binding sitei159 – 1591NADUniRule annotation
Binding sitei176 – 1761NADUniRule annotation
Binding sitei178 – 1781NADUniRule annotation
Binding sitei248 – 2481NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 752NADUniRule annotation
Nucleotide bindingi148 – 1492NADUniRule annotation
Nucleotide bindingi189 – 1946NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-1200-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:YPTB1140
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001011: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293NAD kinasePRO_0000229715Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273123.YPTB1140.

Structurei

3D structure databases

ProteinModelPortaliQ66DA9.
SMRiQ66DA9. Positions 6-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiIRRASCA.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66DA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNRRFDCIG IVGHPRHPAA LATHEILYHW LKARGYAVMV EQQIAHDLNL
60 70 80 90 100
TDAITGSLAD IGQKADLAVV VGGDGNMLGA ARVLARYDIK VIGVNRGNLG
110 120 130 140 150
FLTDLDPDNA LQQLSDVLEG EYLSEQRFLL ETHVRRTNQQ SRISTAINEV
160 170 180 190 200
VLHPGKVAHM IEFEVYIDDR FAFSQRSDGL IIATPTGSTA YSLSAGGPIL
210 220 230 240 250
TPTLDAIVLV PMFPHTLTAR PLVISSTSTI RLKFSHITSD LEISCDSQIA
260 270 280 290
LPIQEGEEVL IRRSDFHLNL IHPKDYSYFN TLSTKLGWSK KLF
Length:293
Mass (Da):32,412
Last modified:October 11, 2004 - v1
Checksum:iC0231B200E8B5E0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX936398 Genomic DNA. Translation: CAH20380.1.
RefSeqiYP_069675.1. NC_006155.1.

Genome annotation databases

EnsemblBacteriaiCAH20380; CAH20380; YPTB1140.
GeneIDi2953485.
KEGGiyps:YPTB1140.
PATRICi18640740. VBIYerPse22266_1447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX936398 Genomic DNA. Translation: CAH20380.1 .
RefSeqi YP_069675.1. NC_006155.1.

3D structure databases

ProteinModelPortali Q66DA9.
SMRi Q66DA9. Positions 6-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273123.YPTB1140.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH20380 ; CAH20380 ; YPTB1140 .
GeneIDi 2953485.
KEGGi yps:YPTB1140.
PATRICi 18640740. VBIYerPse22266_1447.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi IRRASCA.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci YPSE273123:GI1M-1200-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP32953.

Entry informationi

Entry nameiNADK_YERPS
AccessioniPrimary (citable) accession number: Q66DA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3