Q66D83 (GPMA_YERPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Short name=BPG-dependent PGAM
Short name=PGAM
Short name=Phosphoglyceromutase
Short name=dPGM
EC=5.4.2.1

Gene names

Name:	gpmA
Ordered Locus Names:	YPTB1166

Organism

Yersinia pseudotuberculosis serotype I (strain IP32953) [Complete proteome] [HAMAP]

Taxonomic identifier

273123 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia › Yersinia pseudotuberculosis

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP-Rule MF_01039
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP-Rule MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP-Rule MF_01039
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Molecular_function	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 250	250	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase HAMAP-Rule MF_01039		PRO_0000229152
Sites
	Active site	11	1	Tele-phosphohistidine intermediate By similarity
	Active site	184	1	By similarity
	Site	62	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q66D83 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 3AF66E98C0AA8FEC	FASTA	250	28,358
	10 20 30 40 50 60 MAVTKLVLVR HGESQWNNEN RFTGWYDVDL SEKGRSEAKA AGKLLKDEGF TFDFAYTSVL 70 80 90 100 110 120 KRAIHTLWNI LDELDQAWLP TEKTWKLNER HYGALQGLNK SETAEKYGDE QVKQWRRGFA 130 140 150 160 170 180 ITPPALEKSD ERFPGHDPRY AKLTDAELPT TESLALTIER VIPYWNDVIK PRIASGERVI 190 200 210 220 230 240 IAAHGNSLRA LVKYLDDLGE DEILELNIPT GVPLVYEFDE NFKPIKHYYL GNADEIAAKA 250 AAVANQGKAK

References

[1]

"Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis." Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O., Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L., Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C., Simonet M., Chenal-Francisque V., Souza B. , Dacheux D., Elliott J.M., Derbise A., Hauser L.J., Garcia E. Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IP32953.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX936398 Genomic DNA. Translation: CAH20406.1.
RefSeq	YP_069701.1. NC_006155.1.
3D structure databases
ProteinModelPortal	Q66D83.
SMR	Q66D83. Positions 3-241.
ModBase	Search...
Protein-protein interaction databases
STRING	273123.YPTB1166.
Proteomic databases
PRIDE	Q66D83.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAH20406; CAH20406; YPTB1166.
GeneID	2955739.
KEGG	yps:YPTB1166.
PATRIC	18640806. VBIYerPse22266_1473.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0588.
HOGENOM	HOG000221682.
KO	K01834.
OMA	GQSDWNL.
ProtClustDB	PRK14115.
Enzyme and pathway databases
UniPathway	UPA00109; UER00186.
Family and domain databases
HAMAP	MF_01039. PGAM_GpmA.
InterPro	IPR013078. His_Pase_superF_clade-1. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1. [Graphical view]
PANTHER	PTHR11931. PTHR11931. 1 hit.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA_YERPS

Accession

Primary (citable) accession number: Q66D83

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program