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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Iron, Manganese

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-1386-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:YPTB1315
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000001011 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Mannonate dehydratasePRO_0000170695Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ66CT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000195381.
KOiK01686.
OMAiEGDVDMY.
OrthoDBiEOG6ZSP6Z.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66CT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTWRWYGP NDPVSLDDIR QAGATGVVTA LHHIPNGVVW PVSEIKQRQA
60 70 80 90 100
ELAAKNLVWS VVESVPIHED IKTHSGNYQQ YIENYQQTLR NIAECGIDTV
110 120 130 140 150
CYNFMPILDW TRTDLEYELP DGSKALRFDQ IAFAAFELHI LKRPGASNDY
160 170 180 190 200
TAEEQVQAEA YFNAMTEADI AKLTGNIIAG LPGAEEGYTL DQFRARLAEY
210 220 230 240 250
DGIDKAQLRE NMAYFLRAII PVAEQVGLRM AVHPDDPPRP ILGLPRIVST
260 270 280 290 300
IEDMQWLKET VDSIHNGFTM CTGSYGVRAD NDLVKMIETF GDRIHFTHLR
310 320 330 340 350
STCREGNPKT FHEGGHLQGD VDMYSVVKAI LTEEQRRQSL GDMRPIPMRP
360 370 380 390
DHGHQMLDDL HKKTNPGYSA IGRLKGLAEV RGVELALKRT FFPDLKQ
Length:397
Mass (Da):44,876
Last modified:October 11, 2004 - v1
Checksum:i44AA710F5D7C2544
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936398 Genomic DNA. Translation: CAH20555.1.
RefSeqiWP_011192020.1. NZ_CP009712.1.

Genome annotation databases

EnsemblBacteriaiCAH20555; CAH20555; YPTB1315.
KEGGiypo:BZ17_1206.
yps:YPTB1315.
PATRICi18641162. VBIYerPse22266_1648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936398 Genomic DNA. Translation: CAH20555.1.
RefSeqiWP_011192020.1. NZ_CP009712.1.

3D structure databases

ProteinModelPortaliQ66CT7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH20555; CAH20555; YPTB1315.
KEGGiypo:BZ17_1206.
yps:YPTB1315.
PATRICi18641162. VBIYerPse22266_1648.

Phylogenomic databases

HOGENOMiHOG000195381.
KOiK01686.
OMAiEGDVDMY.
OrthoDBiEOG6ZSP6Z.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciYPSE273123:GI1M-1386-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP32953.

Entry informationi

Entry nameiUXUA_YERPS
AccessioniPrimary (citable) accession number: Q66CT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 11, 2004
Last modified: November 11, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.