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Q66CG6

- PNCB_YERPS

UniProt

Q66CG6 - PNCB_YERPS

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Protein

Nicotinate phosphoribosyltransferase

Gene
pncB, YPTB1437
Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-1508-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:YPTB1437
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001011: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Nicotinate phosphoribosyltransferaseUniRule annotationPRO_0000205856Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273123.YPTB1437.

Structurei

3D structure databases

ProteinModelPortaliQ66CG6.
SMRiQ66CG6. Positions 5-377.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66CG6-1 [UniParc]FASTAAdd to Basket

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MTQDASPILT SLLDTDAYKL HMQQAVFHHY RHITVAAEFR CRSDELLGVY    50
ADEIRHQVTL MGQLALTSDE FIYLSSLPFF QDDYLHWLRD FRFKPEQVSV 100
AVHDGKLDIR IAGLWCEVIM WEVPLLAVIS EIVHRRRSTQ VTTDQAVQQL 150
RTKLEQFNAL SADIDITHFK LMDFGTRRRF SREIQHTVVS TLKDEFPYLV 200
GTSNYDLART LALAPVGTQA HEWFQAHQQI SPTLANSQRV ALQVWLDEYP 250
NQLGIALTDC ITMDAFLRDF DLAFANRYQG LRHDSGDPIE WGEKAIAHYE 300
KLGIDPMKKV LVFSDNLDLE KALFLYRHFY QRIKLVFGIG TRLTCDIPDV 350
KPLNIVIKLV ECNDKPVAKL SDSPGKTICQ DPAFVDQLRK AFALPLVKKA 400
S 401
Length:401
Mass (Da):46,022
Last modified:October 11, 2004 - v1
Checksum:i88B37431DA649F2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX936398 Genomic DNA. Translation: CAH20677.1.
RefSeqiYP_069968.1. NC_006155.1.

Genome annotation databases

EnsemblBacteriaiCAH20677; CAH20677; YPTB1437.
GeneIDi2956289.
KEGGiyps:YPTB1437.
PATRICi18641473. VBIYerPse22266_1804.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX936398 Genomic DNA. Translation: CAH20677.1 .
RefSeqi YP_069968.1. NC_006155.1.

3D structure databases

ProteinModelPortali Q66CG6.
SMRi Q66CG6. Positions 5-377.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273123.YPTB1437.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH20677 ; CAH20677 ; YPTB1437 .
GeneIDi 2956289.
KEGGi yps:YPTB1437.
PATRICi 18641473. VBIYerPse22266_1804.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci YPSE273123:GI1M-1508-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP32953.

Entry informationi

Entry nameiPNCB_YERPS
AccessioniPrimary (citable) accession number: Q66CG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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