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Q66C49

- HISX_YERPS

UniProt

Q66C49 - HISX_YERPS

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Protein

Histidinol dehydrogenase

Gene
hisD, YPTB1561
Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331NAD By similarity
Binding sitei191 – 1911NAD By similarity
Binding sitei214 – 2141NAD By similarity
Binding sitei240 – 2401Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Metal bindingi265 – 2651Zinc By similarity
Binding sitei265 – 2651Substrate By similarity
Active sitei329 – 3291Proton acceptor By similarity
Active sitei330 – 3301Proton acceptor By similarity
Binding sitei330 – 3301Substrate By similarity
Metal bindingi363 – 3631Zinc By similarity
Binding sitei363 – 3631Substrate By similarity
Binding sitei417 – 4171Substrate By similarity
Metal bindingi422 – 4221Zinc By similarity
Binding sitei422 – 4221Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-1632-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:YPTB1561
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001011: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Histidinol dehydrogenaseUniRule annotationPRO_0000135888Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi273123.YPTB1561.

Structurei

3D structure databases

ProteinModelPortaliQ66C49.
SMRiQ66C49. Positions 5-433.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiSQDSRCV.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66C49-1 [UniParc]FASTAAdd to Basket

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MQPTNFNTLI NWQQCSEEQQ KALLSRPAIN ASERITATVS DILDRVKAEG    50
DSALRDFSQR FDHVQVADIR ITASEIAAAS ARLSDDVKHA MAQAVRNIEI 100
FHNAQKMPVV DVETQPGVRC QQITRPIASV GLYIPGGSAP LPSTVLMLGT 150
PARIAGCQRV VLCSPPPIAD EILYAAQLCG IQEVFQIGGA QAIAAMAFGS 200
ESVPKVHKIF GPGNAYVTEA KRQVSQRLDG AAIDMPAGPS EVLVIADSGA 250
TPAFIAADLL SQAEHGPDSQ VILLTPDAAI AQAVAVEVEQ QLALLSRADI 300
ARQALESSRL IVTNDLQQCI DISNAYGPEH LILQIRQPEE IIDQIDNAGS 350
VFMGDWSPES AGDYASGTNH VLPTYGYTST YSSLGLADFV KRMTVQQLTP 400
QGLLGLASTI ETLAQAEQLT AHKNAVTLRV TALNNALTAV NKE 443
Length:443
Mass (Da):47,263
Last modified:October 11, 2004 - v1
Checksum:iC8AF3D43698CF00D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX936398 Genomic DNA. Translation: CAH20800.1.
RefSeqiYP_070089.1. NC_006155.1.

Genome annotation databases

EnsemblBacteriaiCAH20800; CAH20800; YPTB1561.
GeneIDi2955792.
KEGGiyps:YPTB1561.
PATRICi18641747. VBIYerPse22266_1940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX936398 Genomic DNA. Translation: CAH20800.1 .
RefSeqi YP_070089.1. NC_006155.1.

3D structure databases

ProteinModelPortali Q66C49.
SMRi Q66C49. Positions 5-433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273123.YPTB1561.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH20800 ; CAH20800 ; YPTB1561 .
GeneIDi 2955792.
KEGGi yps:YPTB1561.
PATRICi 18641747. VBIYerPse22266_1940.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi SQDSRCV.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci YPSE273123:GI1M-1632-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP32953.

Entry informationi

Entry nameiHISX_YERPS
AccessioniPrimary (citable) accession number: Q66C49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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