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Q66C32

- LLDD_YERPS

UniProt

Q66C32 - LLDD_YERPS

Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

    Catalytic activityi

    (S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

    Cofactori

    FMN.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei24 – 241SubstrateUniRule annotation
    Binding sitei106 – 1061FMNUniRule annotation
    Binding sitei127 – 1271FMNUniRule annotation
    Binding sitei129 – 1291SubstrateUniRule annotation
    Binding sitei155 – 1551FMNUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Binding sitei251 – 2511FMNUniRule annotation
    Active sitei275 – 2751Proton acceptorUniRule annotation
    Binding sitei278 – 2781SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi306 – 33025FMNUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. L-lactate dehydrogenase (cytochrome) activity Source: InterPro

    GO - Biological processi

    1. lactate oxidation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Flavoprotein, FMN

    Enzyme and pathway databases

    BioCyciYPSE273123:GI1M-1649-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
    Gene namesi
    Name:lldDUniRule annotation
    Ordered Locus Names:YPTB1578
    OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
    Taxonomic identifieri273123 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000001011: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381L-lactate dehydrogenasePRO_0000206360Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273123.YPTB1578.

    Structurei

    3D structure databases

    ProteinModelPortaliQ66C32.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 380380FMN hydroxy acid dehydrogenaseUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation
    Contains 1 FMN hydroxy acid dehydrogenase domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1304.
    HOGENOMiHOG000217464.
    KOiK00101.
    OMAiDCTLLGR.
    OrthoDBiEOG6HMXBG.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01559. L_lact_dehydr.
    InterProiIPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    IPR020920. L-lactate_DHase_bac.
    [Graphical view]
    PfamiPF01070. FMN_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q66C32-1 [UniParc]FASTAAdd to Basket

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    MIISASTDYR AAAQRKLPPF LFHYIDGGAY NEQTLRRNTA DLADIALRQR    50
    VLKNMSELSL ETQLFGETQA MPVVLGPVGL SGMYARRGEV QAARAADKKG 100
    IPFTLSTLSV CPIEEVAPAI ARPMWFQLYV LKDRGFMRNA LTRAQAAGVK 150
    TLVFTVDMPV PGARYRDAHS GMSGPNAAAR RLLQAIAHPQ WAWDVGLNGK 200
    PHDLGNISAY LGKPTTLEDY MGWIATNFDP SISWKDLEWV REFWQGPMII 250
    KGILDPEDAK DAVKFGADGI VVSNHGGRQL DGVLSTARAL PAIADAVKGD 300
    ITILADSGIR TGLDVVRMIA LGADSVLLGR AFVYALATAG EAGVINLLTL 350
    IEQEMRVAMT LTGAKRIADI NRDSLAVSER G 381
    Length:381
    Mass (Da):41,259
    Last modified:October 11, 2004 - v1
    Checksum:iECC708A08D5E4634
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX936398 Genomic DNA. Translation: CAH20817.1.
    RefSeqiYP_070106.1. NC_006155.1.

    Genome annotation databases

    EnsemblBacteriaiCAH20817; CAH20817; YPTB1578.
    GeneIDi2955956.
    KEGGiyps:YPTB1578.
    PATRICi18641795. VBIYerPse22266_1964.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX936398 Genomic DNA. Translation: CAH20817.1 .
    RefSeqi YP_070106.1. NC_006155.1.

    3D structure databases

    ProteinModelPortali Q66C32.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273123.YPTB1578.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH20817 ; CAH20817 ; YPTB1578 .
    GeneIDi 2955956.
    KEGGi yps:YPTB1578.
    PATRICi 18641795. VBIYerPse22266_1964.

    Phylogenomic databases

    eggNOGi COG1304.
    HOGENOMi HOG000217464.
    KOi K00101.
    OMAi DCTLLGR.
    OrthoDBi EOG6HMXBG.

    Enzyme and pathway databases

    BioCyci YPSE273123:GI1M-1649-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01559. L_lact_dehydr.
    InterProi IPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    IPR020920. L-lactate_DHase_bac.
    [Graphical view ]
    Pfami PF01070. FMN_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IP32953.

    Entry informationi

    Entry nameiLLDD_YERPS
    AccessioniPrimary (citable) accession number: Q66C32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3