Reviewed,
UniProtKB/Swiss-Prot Q66BN4 (PGSA_YERPS)
Last modified
February 9, 2010.
Version 37.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase EC=2.7.8.5 Alternative name(s): Phosphatidylglycerophosphate synthase Short name=PGP synthase | ||||
| Gene names |
| ||||
| Organism | Yersinia pseudotuberculosis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 633 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia |
Protein attributes
| Sequence length | 182 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity. HAMAP MF_01437 |
| Catalytic activity | CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. HAMAP MF_01437 |
| Pathway | Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. HAMAP MF_01437 |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01437. |
| Sequence similarities | Belongs to the CDP-alcohol phosphatidyltransferase class-I family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phospholipid biosynthesis |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: HAMAP |
| Molecular function | CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 182 | 182 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase HAMAP MF_01437 | PRO_0000239136 | |||||
Regions | |||||||||
| Topological domain | 1 – 12 | 12 | Cytoplasmic Potential | ||||||
| Transmembrane | 13 – 37 | 25 | Potential | ||||||
| Topological domain | 38 – 60 | 23 | Periplasmic Potential | ||||||
| Transmembrane | 61 – 81 | 21 | Potential | ||||||
| Topological domain | 82 – 86 | 5 | Cytoplasmic Potential | ||||||
| Transmembrane | 87 – 107 | 21 | Potential | ||||||
| Topological domain | 108 – 145 | 38 | Periplasmic Potential | ||||||
| Transmembrane | 146 – 168 | 23 | Potential | ||||||
| Topological domain | 169 – 181 | 13 | Cytoplasmic Potential | ||||||
Sequences
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References
| [1] | "Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis." Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O., Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L., Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C., Simonet M., Chenal-Francisque V., Souza B. Garcia E.Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004) [PubMed: 15358858] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IP32953 / Serotype I. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX936398 Genomic DNA. Translation: CAH20976.1. |
| RefSeq | YP_070263.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2956246. |
| GenomeReviews | Gene locus YPTB1737 in contig BX936398_GR. |
| KEGG | yps:YPTB1737. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG686655. |
| OMA | TSNIGRM. |
Enzyme and pathway databases | |
| BioCyc | YPSE273123:YPTB1737-MONOMER. |
| BRENDA | 2.7.8.5. 20871. |
Family and domain databases | |
| HAMAP | MF_01437. PgsA. [Tree] |
| InterPro | IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view] |
| Pfam | PF01066. CDP-OH_P_transf. 1 hit. [Graphical view] |
| PIRSF | PIRSF000847. Phos_ph_gly_syn. 1 hit. |
| TIGRFAMs | TIGR00560. pgsA. 1 hit. |
| PROSITE | PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PGSA_YERPS | ||||||||
| Accession | Primary (citable) accession number: Q66BN4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


