Reviewed, UniProtKB/Swiss-Prot Q66BN4 (PGSA_YERPS)

Names and origin

Protein names

Recommended name:
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    EC=2.7.8.5
Alternative name(s):
    Phosphatidylglycerophosphate synthase
      Short name=PGP synthase

Gene names

Name:	pgsA
Ordered Locus Names:	YPTB1737

Organism

Yersinia pseudotuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

633 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity. HAMAP MF_01437
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. HAMAP MF_01437
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. HAMAP MF_01437
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01437.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase HAMAP MF_01437		PRO_0000239136
Regions
	Topological domain	1 – 12	12	Cytoplasmic Potential
	Transmembrane	13 – 37	25	Potential
	Topological domain	38 – 60	23	Periplasmic Potential
	Transmembrane	61 – 81	21	Potential
	Topological domain	82 – 86	5	Cytoplasmic Potential
	Transmembrane	87 – 107	21	Potential
	Topological domain	108 – 145	38	Periplasmic Potential
	Transmembrane	146 – 168	23	Potential
	Topological domain	169 – 181	13	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q66BN4-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 5227A0724C651B9D	FASTA	182	20,806
	10 20 30 40 50 60 MQLNIPTWLT LFRVVLIPFF VLAFYLPFVW APMVCAIIFV FAAATDWFDG FLARRWKQTT 70 80 90 100 110 120 RFGAFLDPVA DKVMVAVALV LVAEHYHSWW ITLPAATMIA REIIISSLRE WMAEIGKRSS 130 140 150 160 170 180 VAVSWVGKVK TMAQMGSLVG LLWRPDHNVE LASFVLLYIA AVLTFWSMFQ YLNAAWSDLL EP

References

[1]

"Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis." Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O., Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L., Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C., Simonet M., Chenal-Francisque V., Souza B. , Dacheux D., Elliott J.M., Derbise A., Hauser L.J., Garcia E. Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004) [PubMed: 15358858] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IP32953 / Serotype I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX936398 Genomic DNA. Translation: CAH20976.1.
RefSeq	YP_070263.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2956246.
GenomeReviews	Gene locus YPTB1737 in contig BX936398_GR.
KEGG	yps:YPTB1737.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG686655.
OMA	TSNIGRM.
Enzyme and pathway databases
BioCyc	YPSE273123:YPTB1737-MONOMER.
BRENDA	2.7.8.5. 20871.
Family and domain databases
HAMAP	MF_01437. PgsA. [Tree]
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMs	TIGR00560. pgsA. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_YERPS

Accession

Primary (citable) accession number: Q66BN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	October 11, 2004
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)