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Q66BN4 (PGSA_YERPS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

EC=2.7.8.5
Alternative name(s):
Phosphatidylglycerophosphate synthase
Short name=PGP synthase
Gene names
Name:pgsA
Ordered Locus Names:YPTB1737
OrganismYersinia pseudotuberculosis serotype I (strain IP32953) [Complete proteome] [HAMAP]
Taxonomic identifier273123 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity. HAMAP-Rule MF_01437

Catalytic activity

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. HAMAP-Rule MF_01437

Pathway

Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. HAMAP-Rule MF_01437

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01437.

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 182182CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase HAMAP-Rule MF_01437
PRO_0000239136

Regions

Topological domain1 – 1212Cytoplasmic Potential
Transmembrane13 – 3725Helical; Potential
Topological domain38 – 6023Periplasmic Potential
Transmembrane61 – 8121Helical; Potential
Topological domain82 – 865Cytoplasmic Potential
Transmembrane87 – 10721Helical; Potential
Topological domain108 – 14538Periplasmic Potential
Transmembrane146 – 16823Helical; Potential
Topological domain169 – 18113Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q66BN4 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 5227A0724C651B9D

FASTA18220,806
        10         20         30         40         50         60 
MQLNIPTWLT LFRVVLIPFF VLAFYLPFVW APMVCAIIFV FAAATDWFDG FLARRWKQTT 

        70         80         90        100        110        120 
RFGAFLDPVA DKVMVAVALV LVAEHYHSWW ITLPAATMIA REIIISSLRE WMAEIGKRSS 

       130        140        150        160        170        180 
VAVSWVGKVK TMAQMGSLVG LLWRPDHNVE LASFVLLYIA AVLTFWSMFQ YLNAAWSDLL 


EP 

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References

[1]"Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis."
Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O., Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L., Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C., Simonet M., Chenal-Francisque V., Souza B. expand/collapse author list , Dacheux D., Elliott J.M., Derbise A., Hauser L.J., Garcia E.
Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IP32953.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX936398 Genomic DNA. Translation: CAH20976.1.
RefSeqYP_070263.1. NC_006155.1.

3D structure databases

ProteinModelPortalQ66BN4.
ModBaseSearch...

Protein-protein interaction databases

STRING273123.YPTB1737.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH20976; CAH20976; YPTB1737.
GeneID2956246.
KEGGyps:YPTB1737.
PATRIC18642183. VBIYerPse22266_2155.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0558.
HOGENOMHOG000010898.
KOK00995.
OMAWSYMAAS.
ProtClustDBPRK10832.

Enzyme and pathway databases

UniPathwayUPA00084; UER00503.

Family and domain databases

HAMAPMF_01437. PgsA.
InterProIPR000462. CDP-OH_P_trans.
IPR023762. PGP_synthase_bac.
IPR004570. Phosphatidylglycerol_P_synth.
[Graphical view]
PfamPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFPIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMsTIGR00560. pgsA. 1 hit.
PROSITEPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGSA_YERPS
AccessionPrimary (citable) accession number: Q66BN4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families