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Protein

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).UniRule annotation

Catalytic activityi

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Menaquinone biosynthesis

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-2646-MONOMER.
UniPathwayiUPA00079.
UPA01057; UER00900.

Protein family/group databases

MEROPSiS33.996.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
Short name:
SHCHC synthaseUniRule annotation
Gene namesi
Name:menHUniRule annotation
Ordered Locus Names:YPTB2559
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001011 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2722722-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthasePRO_0000341934Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi273123.YPTB2559.

Structurei

3D structure databases

ProteinModelPortaliQ669C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MenH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028072.
KOiK08680.
OMAiAGHNAHQ.
OrthoDBiEOG689HPM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01660. MenH.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR022485. SHCHC_synthase_MenH.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q669C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTLACQKLA PHPESPRHQH AGPWLVWLHG LLGSGQDWLP VAQLCGDYPS
60 70 80 90 100
LLIDLPGHGQ SVSLSADGFA DISRQLSQTL QANGIREYWL AGYSLGGRIA
110 120 130 140 150
IYHACYGRHH GLQGLLVEGG NLGLENAELR QARLQQDRQW AQRFRQEPLP
160 170 180 190 200
QVLDDWYQQA VFADLDPQQR EQLVLLRADN HGTAVAEMLE ATSLGHQPWL
210 220 230 240 250
LPALQRLNVP YTYLCGDRDH KFLQLAQQYR LPLHTLARAG HNAHRANPGA
260 270
FAAQVLAFLS QSSCLPPSSL SR
Length:272
Mass (Da):30,258
Last modified:October 10, 2004 - v1
Checksum:i33CE37CF96FC0D21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936398 Genomic DNA. Translation: CAH21797.1.
RefSeqiYP_071069.1. NC_006155.1.

Genome annotation databases

EnsemblBacteriaiCAH21797; CAH21797; YPTB2559.
KEGGiyps:YPTB2559.
PATRICi18644119. VBIYerPse22266_3117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936398 Genomic DNA. Translation: CAH21797.1.
RefSeqiYP_071069.1. NC_006155.1.

3D structure databases

ProteinModelPortaliQ669C8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273123.YPTB2559.

Protein family/group databases

MEROPSiS33.996.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH21797; CAH21797; YPTB2559.
KEGGiyps:YPTB2559.
PATRICi18644119. VBIYerPse22266_3117.

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028072.
KOiK08680.
OMAiAGHNAHQ.
OrthoDBiEOG689HPM.

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00900.
BioCyciYPSE273123:GI1M-2646-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01660. MenH.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR022485. SHCHC_synthase_MenH.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP32953.

Entry informationi

Entry nameiMENH_YERPS
AccessioniPrimary (citable) accession number: Q669C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 30, 2008
Last sequence update: October 10, 2004
Last modified: March 31, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.