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Q669C8 (MENH_YERPS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Short name=SHCHC synthase
EC=4.2.99.20
Gene names
Name:menH
Ordered Locus Names:YPTB2559
OrganismYersinia pseudotuberculosis serotype I (strain IP32953) [Complete proteome] [HAMAP]
Taxonomic identifier273123 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro By similarity. HAMAP-Rule MF_01660

Catalytic activity

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate. HAMAP-Rule MF_01660

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 3/8. HAMAP-Rule MF_01660

Subunit structure

Monomer By similarity. HAMAP-Rule MF_01660

Sequence similarities

Belongs to the AB hydrolase superfamily. MenH family.

Ontologies

Keywords
   Biological processMenaquinone biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmenaquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_function2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2722722-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase HAMAP-Rule MF_01660
PRO_0000341934

Sequences

Sequence LengthMass (Da)Tools
Q669C8 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 33CE37CF96FC0D21

FASTA27230,258
        10         20         30         40         50         60 
MTTLACQKLA PHPESPRHQH AGPWLVWLHG LLGSGQDWLP VAQLCGDYPS LLIDLPGHGQ 

        70         80         90        100        110        120 
SVSLSADGFA DISRQLSQTL QANGIREYWL AGYSLGGRIA IYHACYGRHH GLQGLLVEGG 

       130        140        150        160        170        180 
NLGLENAELR QARLQQDRQW AQRFRQEPLP QVLDDWYQQA VFADLDPQQR EQLVLLRADN 

       190        200        210        220        230        240 
HGTAVAEMLE ATSLGHQPWL LPALQRLNVP YTYLCGDRDH KFLQLAQQYR LPLHTLARAG 

       250        260        270 
HNAHRANPGA FAAQVLAFLS QSSCLPPSSL SR 

« Hide

References

[1]"Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis."
Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O., Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L., Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C., Simonet M., Chenal-Francisque V., Souza B. expand/collapse author list , Dacheux D., Elliott J.M., Derbise A., Hauser L.J., Garcia E.
Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IP32953.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX936398 Genomic DNA. Translation: CAH21797.1.
RefSeqYP_071069.1. NC_006155.1.

3D structure databases

ProteinModelPortalQ669C8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273123.YPTB2559.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH21797; CAH21797; YPTB2559.
GeneID2954333.
KEGGyps:YPTB2559.
PATRIC18644119. VBIYerPse22266_3117.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0596.
HOGENOMHOG000028072.
KOK08680.
OMALGGRIAM.
OrthoDBEOG689HPM.

Enzyme and pathway databases

BioCycYPSE273123:GI1M-2646-MONOMER.
UniPathwayUPA00079; UER00900.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
HAMAPMF_01660. MenH.
InterProIPR029058. AB_hydrolase.
IPR022485. SHCHC_synthase_MenH.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
TIGRFAMsTIGR03695. menH_SHCHC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMENH_YERPS
AccessionPrimary (citable) accession number: Q669C8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways