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Q669C8

- MENH_YERPS

UniProt

Q669C8 - MENH_YERPS

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Protein

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.UniRule annotation

Catalytic activityi

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Menaquinone biosynthesis

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-2646-MONOMER.
UniPathwayiUPA00079.
UPA01057; UER00900.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
Short name:
SHCHC synthaseUniRule annotation
Gene namesi
Name:menHUniRule annotation
Ordered Locus Names:YPTB2559
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001011: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2722722-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthasePRO_0000341934Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi273123.YPTB2559.

Structurei

3D structure databases

ProteinModelPortaliQ669C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MenH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028072.
KOiK08680.
OMAiLGGRIAM.
OrthoDBiEOG689HPM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01660. MenH.
InterProiIPR029058. AB_hydrolase.
IPR022485. SHCHC_synthase_MenH.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q669C8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTLACQKLA PHPESPRHQH AGPWLVWLHG LLGSGQDWLP VAQLCGDYPS
60 70 80 90 100
LLIDLPGHGQ SVSLSADGFA DISRQLSQTL QANGIREYWL AGYSLGGRIA
110 120 130 140 150
IYHACYGRHH GLQGLLVEGG NLGLENAELR QARLQQDRQW AQRFRQEPLP
160 170 180 190 200
QVLDDWYQQA VFADLDPQQR EQLVLLRADN HGTAVAEMLE ATSLGHQPWL
210 220 230 240 250
LPALQRLNVP YTYLCGDRDH KFLQLAQQYR LPLHTLARAG HNAHRANPGA
260 270
FAAQVLAFLS QSSCLPPSSL SR
Length:272
Mass (Da):30,258
Last modified:October 11, 2004 - v1
Checksum:i33CE37CF96FC0D21
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX936398 Genomic DNA. Translation: CAH21797.1.
RefSeqiYP_071069.1. NC_006155.1.

Genome annotation databases

EnsemblBacteriaiCAH21797; CAH21797; YPTB2559.
GeneIDi2954333.
KEGGiyps:YPTB2559.
PATRICi18644119. VBIYerPse22266_3117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX936398 Genomic DNA. Translation: CAH21797.1 .
RefSeqi YP_071069.1. NC_006155.1.

3D structure databases

ProteinModelPortali Q669C8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273123.YPTB2559.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH21797 ; CAH21797 ; YPTB2559 .
GeneIDi 2954333.
KEGGi yps:YPTB2559.
PATRICi 18644119. VBIYerPse22266_3117.

Phylogenomic databases

eggNOGi COG0596.
HOGENOMi HOG000028072.
KOi K08680.
OMAi LGGRIAM.
OrthoDBi EOG689HPM.

Enzyme and pathway databases

UniPathwayi UPA00079 .
UPA01057 ; UER00900 .
BioCyci YPSE273123:GI1M-2646-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
HAMAPi MF_01660. MenH.
InterProi IPR029058. AB_hydrolase.
IPR022485. SHCHC_synthase_MenH.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP32953.

Entry informationi

Entry nameiMENH_YERPS
AccessioniPrimary (citable) accession number: Q669C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3