Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q669C8

- MENH_YERPS

UniProt

Q669C8 - MENH_YERPS

Protein

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro.UniRule annotation

    Catalytic activityi

    5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Menaquinone biosynthesis

    Enzyme and pathway databases

    BioCyciYPSE273123:GI1M-2646-MONOMER.
    UniPathwayiUPA00079; UER00900.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
    Short name:
    SHCHC synthaseUniRule annotation
    Gene namesi
    Name:menHUniRule annotation
    Ordered Locus Names:YPTB2559
    OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
    Taxonomic identifieri273123 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000001011: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2722722-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthasePRO_0000341934Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi273123.YPTB2559.

    Structurei

    3D structure databases

    ProteinModelPortaliQ669C8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. MenH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0596.
    HOGENOMiHOG000028072.
    KOiK08680.
    OMAiLGGRIAM.
    OrthoDBiEOG689HPM.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    HAMAPiMF_01660. MenH.
    InterProiIPR029058. AB_hydrolase.
    IPR022485. SHCHC_synthase_MenH.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q669C8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTLACQKLA PHPESPRHQH AGPWLVWLHG LLGSGQDWLP VAQLCGDYPS    50
    LLIDLPGHGQ SVSLSADGFA DISRQLSQTL QANGIREYWL AGYSLGGRIA 100
    IYHACYGRHH GLQGLLVEGG NLGLENAELR QARLQQDRQW AQRFRQEPLP 150
    QVLDDWYQQA VFADLDPQQR EQLVLLRADN HGTAVAEMLE ATSLGHQPWL 200
    LPALQRLNVP YTYLCGDRDH KFLQLAQQYR LPLHTLARAG HNAHRANPGA 250
    FAAQVLAFLS QSSCLPPSSL SR 272
    Length:272
    Mass (Da):30,258
    Last modified:October 11, 2004 - v1
    Checksum:i33CE37CF96FC0D21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX936398 Genomic DNA. Translation: CAH21797.1.
    RefSeqiYP_071069.1. NC_006155.1.

    Genome annotation databases

    EnsemblBacteriaiCAH21797; CAH21797; YPTB2559.
    GeneIDi2954333.
    KEGGiyps:YPTB2559.
    PATRICi18644119. VBIYerPse22266_3117.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX936398 Genomic DNA. Translation: CAH21797.1 .
    RefSeqi YP_071069.1. NC_006155.1.

    3D structure databases

    ProteinModelPortali Q669C8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273123.YPTB2559.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH21797 ; CAH21797 ; YPTB2559 .
    GeneIDi 2954333.
    KEGGi yps:YPTB2559.
    PATRICi 18644119. VBIYerPse22266_3117.

    Phylogenomic databases

    eggNOGi COG0596.
    HOGENOMi HOG000028072.
    KOi K08680.
    OMAi LGGRIAM.
    OrthoDBi EOG689HPM.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00900 .
    BioCyci YPSE273123:GI1M-2646-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    HAMAPi MF_01660. MenH.
    InterProi IPR029058. AB_hydrolase.
    IPR022485. SHCHC_synthase_MenH.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IP32953.

    Entry informationi

    Entry nameiMENH_YERPS
    AccessioniPrimary (citable) accession number: Q669C8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3