Q66929 (RDRP_FHV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: RNA-directed RNA polymerase Short name=RdRp EC=2.7.7.48 Alternative name(s): RNA replicase Short name=Protein A
Organism	Flock house virus (FHV)
Taxonomic identifier	12287 [NCBI]
Taxonomic lineage	Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Nodaviridae › Alphanodavirus
Virus host	Costelytra zealandica [TaxID: 50579] Galleria mellonella (Greater wax moth) [TaxID: 7137] Hordeum vulgare (Barley) [TaxID: 4513] Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932]

Protein attributes

Sequence length	998 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2 Potential.
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Sequence similarities	Belongs to the nodaviridae RNA polymerase family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase RNA-directed RNA polymerase Transferase
Gene Ontology (GO)
Molecular_function	RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 998	998	RNA-directed RNA polymerase		PRO_0000222446
Regions
	Compositional bias	739 – 742	4	Poly-Thr

Sequences

	Sequence		Length	Mass (Da)
	Q66929 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E9A64CE06555B21C	FASTA	998	112,188
	10 20 30 40 50 60 MTLKVILGEH QITRTELLVG IATVSGCGAV VYCISKFWGY GAIAPYPQSG GNRVTRALQR 70 80 90 100 110 120 AVIDKTKTPI ETRFYPLDSL RTVTPKRVAD NGHAVSGAVR DAARRLIDES ITAVGGSKFE 130 140 150 160 170 180 VNPNPNSSTG LRNHFHFAVG DLAQDFRNDT PADDAFIVGV DVDYYVTEPD VLLEHMRPVV 190 200 210 220 230 240 LHTFNPKKVS GFDADSPFTI KNNLVEYKVS GGAAWVHPVW DWCEAGEFIA SRVRTSWKEW 250 260 270 280 290 300 FLQLPLRMIG LEKVGYHKIH HCRPWTDCPD RALVYTIPQY VIWRFNWIDT ELHVRKLKRI 310 320 330 340 350 360 EYQDETKPGW NRLEYVTDKN ELLVSIGREG EHAQITIEKE KLDMLSGLSA TQSVNARLIG 370 380 390 400 410 420 MGHKDPQYTS MIVQYYTGKK VVSPISPTVY KPTMPRVHWP VTSDADVPEV SARQYTLPIV 430 440 450 460 470 480 SDCMMMPMIK RWETMSESIE RRVTFVANDK KPSDRIAKIA ETFVKLMNGP FKDLDPLSIE 490 500 510 520 530 540 ETIERLNKPS QQLQLRAVFE MIGVKPRQLI ESFNKNEPGM KSSRIISGFP DILFILKVSR 550 560 570 580 590 600 YTLAYSDIVL HAEHNEHWYY PGRNPTEIAD GVCEFVSDCD AEVIETDFSN LDGRVSSWMQ 610 620 630 640 650 660 RNIAQKAMVQ AFRPEYRDEI ISFMDTIINC PAKAKRFGFR YEPGVGVKSG SPTTTPHNTQ 670 680 690 700 710 720 YNGCVEFTAL TFEHPDAEPE DLFRLIGPKC GDDGLSRAII QKSINRAAKC FGLELKVERY 730 740 750 760 770 780 NPEIGLCFLS RVFVDPLATT TTIQDPLRTL RKLHLTTRDP TIPLADAACD RVEGYLCTDA 790 800 810 820 830 840 LTPLISDYCK MVLRLYGPTA STEQVRNQRR SRNKEKPYWL TCDGSWPQHP QDAHLMKQVL 850 860 870 880 890 900 IKRTAIDEDQ VDALIGRFAA MKDVWEKITH DSEESAAACT FDEDGVAPNS VDESLPMLND 910 920 930 940 950 960 AKQTRANPGT SRPHSNGGGS SHGNELPRRT EQRAQGPRQP ARLPKQGKTN GKSDGNITAG 970 980 990 ETQRGGIPRG KGPRGGKTNT RRTPPKAGAQ PQPSNNRK

References

[1]	"Near identity in the polymerase gene of two serologically distinct nodaviruses." Dasgupta R. Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X77156 Genomic RNA. Translation: CAA54399.1.
PIR	S41397.
RefSeq	NP_689444.1. NC_004146.1.
3D structure databases
ProteinModelPortal	Q66929.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	962114.
Family and domain databases
InterPro	IPR020237. RNA-dir_pol_C_nodavirus. [Graphical view]
ProDom	PD029982. RNA-dir_pol_nodavirus. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

RDRP_FHV

Accession

Primary (citable) accession number: Q66929

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	November 1, 1996
Last modified:	May 31, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program