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Q66929

- RDRP_FHV

UniProt

Q66929 - RDRP_FHV

Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Flock house virus (FHV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

    GO - Molecular functioni

    1. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Short name:
    RdRp
    Alternative name(s):
    RNA replicase
    Short name:
    Protein A
    OrganismiFlock house virus (FHV)
    Taxonomic identifieri12287 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeAlphanodavirus
    Virus hostiCostelytra zealandica [TaxID: 50579]
    Galleria mellonella (Greater wax moth) [TaxID: 7137]
    Hordeum vulgare (Barley) [TaxID: 4513]
    Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 998998RNA-directed RNA polymerasePRO_0000222446Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ66929.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi739 – 7424Poly-Thr

    Sequence similaritiesi

    Belongs to the nodaviridae RNA polymerase family.Curated

    Family and domain databases

    InterProiIPR020237. RNA-dir_pol_C_nodavirus.
    [Graphical view]
    ProDomiPD029982. RNA-dir_pol_nodavirus. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q66929-1 [UniParc]FASTAAdd to Basket

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    MTLKVILGEH QITRTELLVG IATVSGCGAV VYCISKFWGY GAIAPYPQSG    50
    GNRVTRALQR AVIDKTKTPI ETRFYPLDSL RTVTPKRVAD NGHAVSGAVR 100
    DAARRLIDES ITAVGGSKFE VNPNPNSSTG LRNHFHFAVG DLAQDFRNDT 150
    PADDAFIVGV DVDYYVTEPD VLLEHMRPVV LHTFNPKKVS GFDADSPFTI 200
    KNNLVEYKVS GGAAWVHPVW DWCEAGEFIA SRVRTSWKEW FLQLPLRMIG 250
    LEKVGYHKIH HCRPWTDCPD RALVYTIPQY VIWRFNWIDT ELHVRKLKRI 300
    EYQDETKPGW NRLEYVTDKN ELLVSIGREG EHAQITIEKE KLDMLSGLSA 350
    TQSVNARLIG MGHKDPQYTS MIVQYYTGKK VVSPISPTVY KPTMPRVHWP 400
    VTSDADVPEV SARQYTLPIV SDCMMMPMIK RWETMSESIE RRVTFVANDK 450
    KPSDRIAKIA ETFVKLMNGP FKDLDPLSIE ETIERLNKPS QQLQLRAVFE 500
    MIGVKPRQLI ESFNKNEPGM KSSRIISGFP DILFILKVSR YTLAYSDIVL 550
    HAEHNEHWYY PGRNPTEIAD GVCEFVSDCD AEVIETDFSN LDGRVSSWMQ 600
    RNIAQKAMVQ AFRPEYRDEI ISFMDTIINC PAKAKRFGFR YEPGVGVKSG 650
    SPTTTPHNTQ YNGCVEFTAL TFEHPDAEPE DLFRLIGPKC GDDGLSRAII 700
    QKSINRAAKC FGLELKVERY NPEIGLCFLS RVFVDPLATT TTIQDPLRTL 750
    RKLHLTTRDP TIPLADAACD RVEGYLCTDA LTPLISDYCK MVLRLYGPTA 800
    STEQVRNQRR SRNKEKPYWL TCDGSWPQHP QDAHLMKQVL IKRTAIDEDQ 850
    VDALIGRFAA MKDVWEKITH DSEESAAACT FDEDGVAPNS VDESLPMLND 900
    AKQTRANPGT SRPHSNGGGS SHGNELPRRT EQRAQGPRQP ARLPKQGKTN 950
    GKSDGNITAG ETQRGGIPRG KGPRGGKTNT RRTPPKAGAQ PQPSNNRK 998
    Length:998
    Mass (Da):112,188
    Last modified:November 1, 1996 - v1
    Checksum:iE9A64CE06555B21C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77156 Genomic RNA. Translation: CAA54399.1.
    PIRiS41397.
    RefSeqiNP_689444.1. NC_004146.1.

    Genome annotation databases

    GeneIDi962114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77156 Genomic RNA. Translation: CAA54399.1 .
    PIRi S41397.
    RefSeqi NP_689444.1. NC_004146.1.

    3D structure databases

    ProteinModelPortali Q66929.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 962114.

    Family and domain databases

    InterProi IPR020237. RNA-dir_pol_C_nodavirus.
    [Graphical view ]
    ProDomi PD029982. RNA-dir_pol_nodavirus. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Near identity in the polymerase gene of two serologically distinct nodaviruses."
      Dasgupta R.
      Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_FHV
    AccessioniPrimary (citable) accession number: Q66929
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3