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Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Flock house virus (FHV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which replicates the viral genome composed of 2 RNA segments, RNA1 AND RNA2.Curated

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RdRp
Alternative name(s):
RNA replicase
Short name:
Protein A
OrganismiFlock house virus (FHV)
Taxonomic identifieri12287 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageNodaviridaeAlphanodavirus
Virus hostiCostelytra zealandica [TaxID: 50579]
Galleria mellonella (Greater wax moth) [TaxID: 7137]
Hordeum vulgare (Barley) [TaxID: 4513]
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 998998RNA-directed RNA polymerasePRO_0000222446Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ66929.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi739 – 7424Poly-Thr

Sequence similaritiesi

Belongs to the nodaviridae RNA polymerase family.Curated

Family and domain databases

InterProiIPR020237. RNA-dir_pol_C_nodavirus.
[Graphical view]
ProDomiPD029982. RNA-dir_pol_nodavirus. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q66929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLKVILGEH QITRTELLVG IATVSGCGAV VYCISKFWGY GAIAPYPQSG
60 70 80 90 100
GNRVTRALQR AVIDKTKTPI ETRFYPLDSL RTVTPKRVAD NGHAVSGAVR
110 120 130 140 150
DAARRLIDES ITAVGGSKFE VNPNPNSSTG LRNHFHFAVG DLAQDFRNDT
160 170 180 190 200
PADDAFIVGV DVDYYVTEPD VLLEHMRPVV LHTFNPKKVS GFDADSPFTI
210 220 230 240 250
KNNLVEYKVS GGAAWVHPVW DWCEAGEFIA SRVRTSWKEW FLQLPLRMIG
260 270 280 290 300
LEKVGYHKIH HCRPWTDCPD RALVYTIPQY VIWRFNWIDT ELHVRKLKRI
310 320 330 340 350
EYQDETKPGW NRLEYVTDKN ELLVSIGREG EHAQITIEKE KLDMLSGLSA
360 370 380 390 400
TQSVNARLIG MGHKDPQYTS MIVQYYTGKK VVSPISPTVY KPTMPRVHWP
410 420 430 440 450
VTSDADVPEV SARQYTLPIV SDCMMMPMIK RWETMSESIE RRVTFVANDK
460 470 480 490 500
KPSDRIAKIA ETFVKLMNGP FKDLDPLSIE ETIERLNKPS QQLQLRAVFE
510 520 530 540 550
MIGVKPRQLI ESFNKNEPGM KSSRIISGFP DILFILKVSR YTLAYSDIVL
560 570 580 590 600
HAEHNEHWYY PGRNPTEIAD GVCEFVSDCD AEVIETDFSN LDGRVSSWMQ
610 620 630 640 650
RNIAQKAMVQ AFRPEYRDEI ISFMDTIINC PAKAKRFGFR YEPGVGVKSG
660 670 680 690 700
SPTTTPHNTQ YNGCVEFTAL TFEHPDAEPE DLFRLIGPKC GDDGLSRAII
710 720 730 740 750
QKSINRAAKC FGLELKVERY NPEIGLCFLS RVFVDPLATT TTIQDPLRTL
760 770 780 790 800
RKLHLTTRDP TIPLADAACD RVEGYLCTDA LTPLISDYCK MVLRLYGPTA
810 820 830 840 850
STEQVRNQRR SRNKEKPYWL TCDGSWPQHP QDAHLMKQVL IKRTAIDEDQ
860 870 880 890 900
VDALIGRFAA MKDVWEKITH DSEESAAACT FDEDGVAPNS VDESLPMLND
910 920 930 940 950
AKQTRANPGT SRPHSNGGGS SHGNELPRRT EQRAQGPRQP ARLPKQGKTN
960 970 980 990
GKSDGNITAG ETQRGGIPRG KGPRGGKTNT RRTPPKAGAQ PQPSNNRK
Length:998
Mass (Da):112,188
Last modified:November 1, 1996 - v1
Checksum:iE9A64CE06555B21C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77156 Genomic RNA. Translation: CAA54399.1.
PIRiS41397.
RefSeqiNP_689444.1. NC_004146.1.

Genome annotation databases

GeneIDi962114.
KEGGivg:962114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77156 Genomic RNA. Translation: CAA54399.1.
PIRiS41397.
RefSeqiNP_689444.1. NC_004146.1.

3D structure databases

ProteinModelPortaliQ66929.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi962114.
KEGGivg:962114.

Family and domain databases

InterProiIPR020237. RNA-dir_pol_C_nodavirus.
[Graphical view]
ProDomiPD029982. RNA-dir_pol_nodavirus. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Near identity in the polymerase gene of two serologically distinct nodaviruses."
    Dasgupta R.
    Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_FHV
AccessioniPrimary (citable) accession number: Q66929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.