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Protein

Protein VP2

Gene

ORF3

Organism
Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Minor structural protein present in one or two copies per virion. Does not seem to play a role in capsid assembly, but is essential for production of infectious virus.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein VP2
Alternative name(s):
Minor capsid protein
Gene namesi
ORF Names:ORF3
OrganismiFeline calicivirus (strain Cat/United States/Urbana/1960) (FCV)
Taxonomic identifieri292349 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeVesivirus
Virus hostiFelis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
ProteomesiUP000001098 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
  2. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 106106Protein VP2PRO_0000100125Add
BLAST

Interactioni

Subunit structurei

May interact with capsid protein.

Family & Domainsi

Sequence similaritiesi

Belongs to the vesivirus VP2 protein family.Curated

Family and domain databases

InterProiIPR007996. Vesivirus_VP2.
[Graphical view]
PfamiPF05332. DUF743. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSILGLIDT VTNTIGKAQQ IELDKAALGQ QRELALQRMN LDRQALNNQV
60 70 80 90 100
EQFNKILEQR VQGPLQSVRL ARAAGFRVDP YSYTNQNFYD DQLNAIRLSY

RNLFKN
Length:106
Mass (Da):12,199
Last modified:November 1, 1996 - v1
Checksum:iDCD55D2DE1967F13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40021 Genomic RNA. Translation: AAA79325.1.
RefSeqiNP_783198.1. NC_001481.2.

Genome annotation databases

GeneIDi1502253.
KEGGivg:1502253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40021 Genomic RNA. Translation: AAA79325.1.
RefSeqiNP_783198.1. NC_001481.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1502253.
KEGGivg:1502253.

Family and domain databases

InterProiIPR007996. Vesivirus_VP2.
[Graphical view]
PfamiPF05332. DUF743. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "RNA transcripts derived from a cloned full-length copy of the feline calicivirus genome do not require VpG for infectivity."
    Sosnovtsev S.V., Green K.Y.
    Virology 210:383-390(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Identification and genomic mapping of the ORF3 and VPg proteins in feline calicivirus virions."
    Sosnovtsev S.V., Green K.Y.
    Virology 277:193-203(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-20 AND 102-106, IDENTIFICATION.
  3. "Feline calicivirus VP2 is essential for the production of infectious virions."
    Sosnovtsev S.V., Belliot G., Chang K.O., Onwudiwe O., Green K.Y.
    J. Virol. 79:4012-4024(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Analysis of protein-protein interactions in the feline calicivirus replication complex."
    Kaiser W.J., Chaudhry Y., Sosnovtsev S.V., Goodfellow I.G.
    J. Gen. Virol. 87:363-368(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CAPSID PROTEIN.

Entry informationi

Entry nameiVP2_FCVUR
AccessioniPrimary (citable) accession number: Q66916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

Translated by a ribosomal terminaition-reinitiation process from the bicistronic mRNA coding for VP1 and VP2.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.