Q66916 (VP2_FCVUR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein VP2

Alternative name(s):
Minor capsid protein

Gene names

ORF Names:

ORF3

Organism

Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV) [Reference proteome]

Taxonomic identifier

292349 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Caliciviridae › Vesivirus › Feline calicivirus

Virus host

Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Minor structural protein present in one or two copies per virion. Does not seem to play a role in capsid assembly, but is essential for production of infectious virus. Ref.3
Subunit structure	May interact with capsid protein.
Subcellular location	Virion. Host cytoplasm.
Miscellaneous	Translated by a ribosomal terminaition-reinitiation process from the bicistronic mRNA encoding for VP1 and VP2.
Sequence similarities	Belongs to the vesivirus VP2 protein family.

Ontologies

Keywords
Cellular component	Host cytoplasm Virion
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 106	106	Protein VP2		PRO_0000100125

Sequences

	Sequence		Length	Mass (Da)
	Q66916 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: DCD55D2DE1967F13	FASTA	106	12,199
	10 20 30 40 50 60 MNSILGLIDT VTNTIGKAQQ IELDKAALGQ QRELALQRMN LDRQALNNQV EQFNKILEQR 70 80 90 100 VQGPLQSVRL ARAAGFRVDP YSYTNQNFYD DQLNAIRLSY RNLFKN

References

[1]	"RNA transcripts derived from a cloned full-length copy of the feline calicivirus genome do not require VpG for infectivity." Sosnovtsev S.V., Green K.Y. Virology 210:383-390(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]	"Identification and genomic mapping of the ORF3 and VPg proteins in feline calicivirus virions." Sosnovtsev S.V., Green K.Y. Virology 277:193-203(2000) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-20 AND 102-106, IDENTIFICATION.
[3]	"Feline calicivirus VP2 is essential for the production of infectious virions." Sosnovtsev S.V., Belliot G., Chang K.O., Onwudiwe O., Green K.Y. J. Virol. 79:4012-4024(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[4]	"Analysis of protein-protein interactions in the feline calicivirus replication complex." Kaiser W.J., Chaudhry Y., Sosnovtsev S.V., Goodfellow I.G. J. Gen. Virol. 87:363-368(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CAPSID PROTEIN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L40021 Genomic RNA. Translation: AAA79325.1.
RefSeq	NP_783198.1. NC_001481.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1502253.
Family and domain databases
InterPro	IPR007996. Vesivirus_VP2. [Graphical view]
Pfam	PF05332. DUF743. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VP2_FCVUR

Accession

Primary (citable) accession number: Q66916

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program