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Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-2934-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
Alternative name(s):
Histidyl-tRNA synthetaseUniRule annotation
Short name:
HisRSUniRule annotation
Gene namesi
Name:hisSUniRule annotation
Ordered Locus Names:YPTB2840
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001011 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Histidine--tRNA ligasePRO_0000136306Add
BLAST

Proteomic databases

PRIDEiQ668A0.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ668A0.
SMRiQ668A0. Positions 4-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018072.
KOiK01892.
OMAiCGGGNFK.
OrthoDBiEOG6BPDH4.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q668A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNIQAIRG MNDYLPADTA IWQRIESILK QVLSGYGYSE IRMPIVEQTP
60 70 80 90 100
LFKRAIGEVT DVVEKEMYTF DDRNGESLTL RPEGTAGCVR AGIEHGLLYN
110 120 130 140 150
QEQRLWYIGP MFRYERPQKG RYRQFHQLGA EVFGLPGPDI DAELILLTAR
160 170 180 190 200
WWRALGIFEH VKLELNSIGS LAARADYREA LVAFLEQHVE VLDEDCKRRM
210 220 230 240 250
YSNPLRVLDS KNPDVQQLLD DAPKLSDYLD EESKQHFAGL CELLDKASIP
260 270 280 290 300
YTVNERLVRG LDYYNRTVFE WVTHSLGAQG TVCAGGRYDG LVEQLGGRAT
310 320 330 340 350
PAVGFAMGLE RLVLLVQAVN ADFQVPATVD AYVISSGEGA QSAAMLLAES
360 370 380 390 400
LRDALPTLKI MTNYGGGNVK KQFTRADKWG ARVALMLGES EVAAQQVVVK
410 420
DLRNGEQETL AQADVAARLA LMLG
Length:424
Mass (Da):47,262
Last modified:October 11, 2004 - v1
Checksum:iB6DAD3B591E6703D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936398 Genomic DNA. Translation: CAH22078.1.
RefSeqiWP_002209816.1. NC_006155.1.
YP_071347.1. NC_006155.1.

Genome annotation databases

EnsemblBacteriaiCAH22078; CAH22078; YPTB2840.
KEGGiyps:YPTB2840.
PATRICi18644807. VBIYerPse22266_3454.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936398 Genomic DNA. Translation: CAH22078.1.
RefSeqiWP_002209816.1. NC_006155.1.
YP_071347.1. NC_006155.1.

3D structure databases

ProteinModelPortaliQ668A0.
SMRiQ668A0. Positions 4-424.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ668A0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH22078; CAH22078; YPTB2840.
KEGGiyps:YPTB2840.
PATRICi18644807. VBIYerPse22266_3454.

Phylogenomic databases

eggNOGiCOG0124.
HOGENOMiHOG000018072.
KOiK01892.
OMAiCGGGNFK.
OrthoDBiEOG6BPDH4.

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-2934-MONOMER.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
HAMAPiMF_00127. His_tRNA_synth.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP32953.

Entry informationi

Entry nameiSYH_YERPS
AccessioniPrimary (citable) accession number: Q668A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 11, 2004
Last modified: June 24, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.