Q667W1 (PUR4_YERPS) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 49.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phosphoribosylformylglycinamidine synthase Short name=FGAM synthase Short name=FGAMS EC=6.3.5.3 Alternative name(s): Formylglycinamide ribotide amidotransferase Short name=FGARAT Formylglycinamide ribotide synthetase | ||||
| Gene names |
| ||||
| Organism | Yersinia pseudotuberculosis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 633 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia |
Protein attributes
| Sequence length | 1296 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP MF_00419 |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP MF_00419 |
| Subunit structure | Monomer. |
| Subcellular location | |
| Sequence similarities | In the N-terminal section; belongs to the FGAMS family. Contains 1 glutamine amidotransferase type-1 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Cellular component | Cytoplasm |
| Domain | Glutamine amidotransferase |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro glutamine metabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine synthase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1296 | 1296 | Phosphoribosylformylglycinamidine synthase HAMAP MF_00419 | PRO_0000264604 | |||||
Regions | |||||||||
| Domain | 1043 – 1296 | 254 | Glutamine amidotransferase type-1 | ||||||
| Nucleotide binding | 306 – 317 | 12 | ATP Potential | ||||||
Sites | |||||||||
| Active site | 1136 | 1 | Nucleophile By similarity | ||||||
| Active site | 1261 | 1 | By similarity | ||||||
| Active site | 1263 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis." Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O., Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L., Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C., Simonet M., Chenal-Francisque V., Souza B.  Garcia E.Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004) [PubMed: 15358858] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IP32953 / Serotype I. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX936398 Genomic DNA. Translation: CAH22117.1. |
| RefSeq | YP_071386.1. NC_006155.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1T3T based on UniProtKB P74881. |
| ProteinModelPortal | Q667W1. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2956375. |
| GenomeReviews | Gene locus YPTB2879 in contig BX936398_GR. |
| KEGG | yps:YPTB2879. |
| PATRIC | 18644899. VBIYerPse22266_3500. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG335309. |
| OMA | VKAVGME. |
| ProtClustDB | PRK05297. |
Enzyme and pathway databases | |
| BioCyc | YPSE273123:YPTB2879-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00419. PurL_1. [Tree] |
| InterPro | IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR017926. GATASE_1. IPR010073. PRibForGlyAmidine_synth. IPR022940. PRibForGlyAmidine_synth_bac. IPR016188. PurM_N-like. [Graphical view] |
| KO | K01952. |
| Pfam | PF00586. AIRS. 1 hit. PF02769. AIRS_C. 2 hits. [Graphical view] |
| SUPFAM | SSF56042. AIR_synth_C. 2 hits. SSF55326. PurM_N-like. 2 hits. |
| TIGRFAMs | TIGR01735. FGAM_synt. 1 hit. |
| PROSITE | PS51273. GATASE_TYPE_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PUR4_YERPS | ||||||||
| Accession | Primary (citable) accession number: Q667W1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |