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Q667K2

- LPXB_YERPS

UniProt

Q667K2 - LPXB_YERPS

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-3091-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:YPTB2990
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001011: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Lipid-A-disaccharide synthasePRO_0000255236Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273123.YPTB2990.

Structurei

3D structure databases

ProteinModelPortaliQ667K2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q667K2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQNSPLTADC SLNAGRPLTI GLVAGETSGD ILGAGLIRAL KVQVPNARFV
60 70 80 90 100
GVAGPLMQAE GCEAWYEMEE LAVMGVVEVL ERLPRLLKIR KDLTQRFSEL
110 120 130 140 150
SPDVFVGIDA PDFNITLEGR LKQRGIRTIH YVSPSVWAWR QKRVFKIGKA
160 170 180 190 200
TDMVLAFLPF EKAFYDRFNV PCRFIGHTMA DAMPLVPDQQ AARAELGIAP
210 220 230 240 250
NATCLALLPG SRHSEVEMLS ADFLRTAVIL RDKLPNLEVV VPLVNSKRRE
260 270 280 290 300
QFERIKAEIA PDLSVHLLDG KARVAMIASD AALLASGTAA LECMLAKCPM
310 320 330 340 350
VVGYRMKPFT FWLAERLVKT PYVSLPNLLA GEELVTELLQ QECQPQKLAG
360 370 380 390
ALLPLLQGGS EIAALKERFL VLHQSIRCGA DEQAAQAVLE LADR
Length:394
Mass (Da):43,261
Last modified:October 11, 2004 - v1
Checksum:iF4A481D7C188B25C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936398 Genomic DNA. Translation: CAH22228.1.
RefSeqiYP_071496.1. NC_006155.1.

Genome annotation databases

EnsemblBacteriaiCAH22228; CAH22228; YPTB2990.
GeneIDi2955967.
KEGGiyps:YPTB2990.
PATRICi18645163. VBIYerPse22266_3626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX936398 Genomic DNA. Translation: CAH22228.1 .
RefSeqi YP_071496.1. NC_006155.1.

3D structure databases

ProteinModelPortali Q667K2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273123.YPTB2990.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH22228 ; CAH22228 ; YPTB2990 .
GeneIDi 2955967.
KEGGi yps:YPTB2990.
PATRICi 18645163. VBIYerPse22266_3626.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci YPSE273123:GI1M-3091-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP32953.

Entry informationi

Entry nameiLPXB_YERPS
AccessioniPrimary (citable) accession number: Q667K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3