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Protein

CARD domain-containing protein E10

Gene

E10

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Activates host NF-kappa-B and JNK pathways. Induces hyperphosphorylation and redistribution of host bcl-10 from the cytoplasm to the plasma membrane. The inhibitory effect of cellular bcl-10 on NF-kappa-B pathway is then overcome allowing NF-kappa-B activation.2 Publications

GO - Molecular functioni

  • protein self-association Source: AgBase

GO - Biological processi

Keywordsi

Biological processActivation of host NF-kappa-B by virus, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
CARD domain-containing protein E10
Gene namesi
Name:E10
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000007083 Componenti: Genome

Subcellular locationi

Q66677:
  • Host cell membrane 1 Publication
  • Note: E10 does not contain a putative transmembrane and must therefore be targeted to the plasma membrane in a different manner. The two cysteines located on the C-terminal region are essential for the protein localization and constitute a consensus site for geranylgeranylation.

GO - Cellular componenti

  • host cell plasma membrane Source: AgBase
  • membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi310C → A: Loss of host plasma membrane localization. 1 Publication1
Mutagenesisi311C → A: Loss of host plasma membrane localization. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004059841 – 311CARD domain-containing protein E10Add BLAST311

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein self-association Source: AgBase

Protein-protein interaction databases

IntActiQ66677. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ66677.
SMRiQ66677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 110CARDPROSITE-ProRule annotationAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi222 – 228Poly-Gly7
Compositional biasi233 – 238Poly-Gly6
Compositional biasi253 – 260Poly-Gly8

Family and domain databases

InterProiView protein in InterPro
IPR033238. BCL10/E10.
IPR001315. CARD.
IPR011029. DEATH-like_dom.
PANTHERiPTHR34920. PTHR34920. 1 hit.
PfamiView protein in Pfam
PF00619. CARD. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50209. CARD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKYPLQAG DPCVTLTEED IWDVERLCLE ELRVLLVSHL KSHKHLDHLR
60 70 80 90 100
AKKILSREDA EEVSSRATSR SRAGLLVDMC QDHPRGFQCL KESCKNEVGQ
110 120 130 140 150
EHLVDLLERA FEKHCGDKLT QKWWESGADG RNPRRPPGSE DNSGYTALLP
160 170 180 190 200
TNPSGGGPSI GSGHSRPRGR DDSGGIGGGV YPFSHGGARV VGGGWGGWGE
210 220 230 240 250
SGGAGRGGSL LSGGHGGHPP HGGPGGGGRD YYGGGGSGYY ESIPEPANFP
260 270 280 290 300
NSGGGGRGGG VRYDAGGDGR LGGLPPDPQE VDDPSLSVQG RGGPAPDPPS
310
PPLRTRRFFC C
Length:311
Mass (Da):32,602
Last modified:March 8, 2011 - v2
Checksum:i04EC68C7353D723B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20824 Genomic DNA. Translation: AAC13865.2.
PIRiS55671.
RefSeqiNP_042674.2. NC_001650.2.

Genome annotation databases

GeneIDi1461015.
KEGGivg:1461015.

Similar proteinsi

Entry informationi

Entry nameiVCLAP_EHV2
AccessioniPrimary (citable) accession number: Q66677
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 10, 2017
This is version 72 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome