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Protein

Nuclear egress protein 2

Gene

NEC2

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear egress protein 2
Gene namesi
Name:NEC2
Ordered Locus Names:67
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000007083 Componenti: Genome

Subcellular locationi

  • Host nucleus inner membrane ; Single-pass membrane protein
  • Note: Localizes also at the transient membrane of perinuclear virions.

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 264Perinuclear spaceAdd BLAST264
Transmembranei265 – 283HelicalAdd BLAST19
Topological domaini284 – 287Nuclear4

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Host nucleus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004060651 – 287Nuclear egress protein 2Add BLAST287

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ66669.

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Forms a heterohexameric complex with NEC1.

Structurei

3D structure databases

SMRiQ66669.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae NEC2 protein family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000J9.

Family and domain databases

HAMAPiMF_04024. HSV_NEC2. 1 hit.
InterProiView protein in InterPro
IPR007626. Herpesvirus_viron_egress-type.
PfamiView protein in Pfam
PF04541. Herpes_U34. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGSKRLVAQ LCQVVRSFIC QPGTAVDLWQ CAAGPHVFAK GSTQPICIVK
60 70 80 90 100
LVHGQIYNLE FVYKYWCHIL QSEKFPYSPV FIISNNGLAI TLKCFLCEPM
110 120 130 140 150
DLHSQFGRCL SMDTDVYLPK NTSVVLSQDD FTKFKTNLVF SKDLNVFNSM
160 170 180 190 200
VVCRTYLTDF RQALQFLVVK AKNPKRVTAI LGTIAQTLGL TPDTRSGEGG
210 220 230 240 250
KNSERGEDDM VRRPIRAHRA GDSGGSPGTL PAEPQGAPTP PGGGLGLSSG
260 270 280
LGLVRRWTRC AFQRYFTVLA VGAVAAATFL AGAKLTG
Length:287
Mass (Da):31,241
Last modified:November 1, 1996 - v1
Checksum:i9DF2417CB377BD56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20824 Genomic DNA. Translation: AAC13855.1.
PIRiS55662.
RefSeqiNP_042664.1. NC_001650.2.

Genome annotation databases

GeneIDi1461027.
KEGGivg:1461027.

Similar proteinsi

Entry informationi

Entry nameiNEC2_EHV2
AccessioniPrimary (citable) accession number: Q66669
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 1, 1996
Last modified: February 15, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families