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Protein

Inner tegument protein

Gene

63

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an essential role in cytoplasmic secondary envelopment during viral egress. Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs. Modulates tegumentation and capsid accumulation at the viral assembly complex.UniRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Inner tegument proteinUniRule annotation
Gene namesi
Name:63
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000007083 Componenti: Genome

Subcellular locationi

  • Virion tegument UniRule annotation
  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation
  • host trans-Golgi network UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host Golgi apparatus, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004060401 – 965Inner tegument proteinAdd BLAST965

Interactioni

Subunit structurei

Interacts (via C-teminus) with the large tegument protein/LTP (via N-terminus).UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni489 – 965Interaction with large tegument proteinUniRule annotationAdd BLAST477

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi503 – 520Gly-richAdd BLAST18
Compositional biasi680 – 684Poly-Ala5

Sequence similaritiesi

Belongs to the herpesviridae inner tegument protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900001P.

Family and domain databases

HAMAPiMF_04043. HSV_ITP. 1 hit.
InterProiView protein in InterPro
IPR007611. Herpes_U30.
IPR034738. HSV_ITP.
PfamiView protein in Pfam
PF04523. Herpes_U30. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPQASLDRL AQRLSDAENL FKKVRVLVDL ESAPLSLRSL SDPVRIASFL
60 70 80 90 100
NTLSDRGNEY LAFIRHRPAF YLLRVASFGE QVPLGAGDLQ GAVGLLTSAV
110 120 130 140 150
RAFKDLKPPP EGTPAPANNL LENSNILTRL SQFIAHLRSL DLSQPVTFTP
160 170 180 190 200
PASLVTLRCI EEITFSFWHA HWTAPPEVSL PKPNPQSKLE RWLALSYAAA
210 220 230 240 250
LGAARDNAPK HRRELRALAK SLLTTERDLF APVSVVTETS LTLPLAKERA
260 270 280 290 300
REIFSMVDDA LPGDAAARGA PVLGFRDADL NAASPEYVFL YEHVFEALLH
310 320 330 340 350
DQTYGCARRT VEAFLERCLK FLVNLGSYVQ TACSNKSHLS PPEIEGVRAA
360 370 380 390 400
FHACGLTREA CHTFSTMLAI APAGGAASRL KHLHATVQHL EQITVFGRHF
410 420 430 440 450
YECLRRCSPT SISHRLVREV LRTAQVEQNS ATPWTAGAAE GSALGWPVHS
460 470 480 490 500
YLRIFLPRPP EDDLAATFKA ASESNFMKSL IGVSVKRDWD LNKFYVLSKK
510 520 530 540 550
APGGGGNGEG GSGGGNGGAG TVSRKQVRKF CEGLNPGDAD YALEVVQSKY
560 570 580 590 600
FAPEFARAVL LPELEAMLRG RVRRHVMLFR LRWLVLFAFE DAAGLAHIRR
610 620 630 640 650
PLTLAYFQLT EIFGQGGVGS GAGAAGGGDG GALGNLLDHF HEAWTAAREL
660 670 680 690 700
VPEAGGEVPH ELLTNIYRSL HAPAAREQLA AAAAFLKEIK PLVEGTWNMM
710 720 730 740 750
RIASVLCHAR YNYLSASGHL RVPFGEKPGY VDVPVPVFKE TVKIMESSLH
760 770 780 790 800
ETLVILSQAC QDLQRFYAAC LGILDQNQFL ATHPVQLDLS EPDFQAVKET
810 820 830 840 850
LLGCLRRYRE VASLAAGSCC FSLTRHFGAL FDPPLITEAV VRKVLEFSEE
860 870 880 890 900
RDTTDAFIES LQQPIAKVEE EDWDDAPPKH ALNDYDLTAL REINESFPLP
910 920 930 940 950
KQHGNNPPET TPSIKLSYTD SVNVSQITLD WEKFLRTSYI PQDAITSEFS
960
HITVKKLEQS ITGSF
Length:965
Mass (Da):106,096
Last modified:November 1, 1996 - v1
Checksum:i4DCEE61E977B4C54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20824 Genomic DNA. Translation: AAC13851.1.
PIRiS55658.
RefSeqiNP_042660.1. NC_001650.2.

Genome annotation databases

GeneIDi1461054.
KEGGivg:1461054.

Similar proteinsi

Entry informationi

Entry nameiITP_EHV2
AccessioniPrimary (citable) accession number: Q66665
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families