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Q66663

- RIR1_EHV2

UniProt

Q66663 - RIR1_EHV2

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Protein
Ribonucleoside-diphosphate reductase large subunit
Gene
61
Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei192 – 1921Substrate By similarity
Sitei208 – 2081Important for hydrogen atom transfer By similarity
Binding sitei238 – 2381Substrate; via amide nitrogen By similarity
Active sitei408 – 4081Proton acceptor By similarity
Active sitei410 – 4101Cysteine radical intermediate By similarity
Active sitei412 – 4121Proton acceptor By similarity
Sitei424 – 4241Important for hydrogen atom transfer By similarity
Sitei743 – 7431Important for electron transfer By similarity
Sitei744 – 7441Important for electron transfer By similarity
Sitei795 – 7951Interacts with thioredoxin/glutaredoxin By similarity
Sitei798 – 7981Interacts with thioredoxin/glutaredoxin By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase large subunit (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase large subunit
Gene namesi
Name:61
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
ProteomesiUP000007083: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 799799Ribonucleoside-diphosphate reductase large subunit
PRO_0000405987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi208 ↔ 424Redox-active By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Keywords - Developmental stagei

Early protein

Structurei

3D structure databases

ProteinModelPortaliQ66663.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 2082Substrate binding By similarity
Regioni408 – 4125Substrate binding By similarity
Regioni612 – 6165Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66663-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAHLGMPV PVYMAEREED LALRKLIDTL KISAGWDLEA NRMAGRLYHF    50
VMGRRAPVDT RAYVTTFGDK LEKGVHRFLW DNARDIDDLC KDFQNGPEYE 100
RLISRGMLSA KRMYDTYVLR TEEGGGEGAV YESALQMYAR MAAFFTCQCF 150
AYPSLRKTVS EVEGGSGRME SGLDFFAYFF KILASQLVSC ATPVMRSAGL 200
RQSYLASCFI MNPDMSTEDK TLSAVFRDLS PLLCSKSGVG MNLTNFSSGG 250
KNVQSCLRLI NSQVEFCNDK NLRPVSVAAY MELWHEQIEE FLAAKLPENP 300
ERCQSIFQGV CVPGLFFRLY EQNPDSQWHL FSPKVGGHLA GLYGDKFDEE 350
YARLVRHGLY SSSLPAKSLM FALISAIIKT GSPYILSKDA INRHHWFETQ 400
GNAISYANLC AEVVQQPHEF TSTCNLANVC LPACLRARGE GEGAGAAGEG 450
EGADRLSPLT PDLEFCFDTL RAAVRAAVYM INASILGGVC PTPGVRVMQA 500
ERSAGIGVQG LADVFAKLGR GYMDAESALL DARIFEVMYY QAVRASNQLV 550
TVGGAPPHAN WKNSKLSRGE FHWESWGVQY DSLFIERQLW EELRESVTKH 600
GTFNSQFIAL MPTAGTSQLT GLSESFYPFY ANVSSKVSNK EEVMKPNITF 650
LERVSPSDVP LLKYHGGDVS KLPPPLAAKY RNFLTAFDYS PEDQIRRAAA 700
RSPFVDQSQS FSFFLKEANV KSASYVKNLI LLGHGLGLKT IMYYCRIQKQ 750
TSLTALECLQ CTESPDSGDG VGGYKGGDEE PRSPEHAQCE SPDRCLSCQ 799
Length:799
Mass (Da):88,581
Last modified:November 1, 1996 - v1
Checksum:iA88D2540357934F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20824 Genomic DNA. Translation: AAC13849.1.
PIRiS55656.
RefSeqiNP_042658.1. NC_001650.1.

Genome annotation databases

GeneIDi1461053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20824 Genomic DNA. Translation: AAC13849.1 .
PIRi S55656.
RefSeqi NP_042658.1. NC_001650.1.

3D structure databases

ProteinModelPortali Q66663.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1461053.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

InterProi IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view ]
PRINTSi PR01183. RIBORDTASEM1.
TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR1_EHV2
AccessioniPrimary (citable) accession number: Q66663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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