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Q66663

- RIR1_EHV2

UniProt

Q66663 - RIR1_EHV2

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Protein

Ribonucleoside-diphosphate reductase large subunit

Gene

61

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei192 – 1921SubstrateBy similarity
Sitei208 – 2081Important for hydrogen atom transferBy similarity
Binding sitei238 – 2381Substrate; via amide nitrogenBy similarity
Active sitei408 – 4081Proton acceptorBy similarity
Active sitei410 – 4101Cysteine radical intermediateBy similarity
Active sitei412 – 4121Proton acceptorBy similarity
Sitei424 – 4241Important for hydrogen atom transferBy similarity
Sitei743 – 7431Important for electron transferBy similarity
Sitei744 – 7441Important for electron transferBy similarity
Sitei795 – 7951Interacts with thioredoxin/glutaredoxinBy similarity
Sitei798 – 7981Interacts with thioredoxin/glutaredoxinBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase large subunit (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase large subunit
Gene namesi
Name:61
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
ProteomesiUP000007083: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 799799Ribonucleoside-diphosphate reductase large subunitPRO_0000405987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi208 ↔ 424Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Expressioni

Keywords - Developmental stagei

Early protein

Structurei

3D structure databases

ProteinModelPortaliQ66663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 2082Substrate bindingBy similarity
Regioni408 – 4125Substrate bindingBy similarity
Regioni612 – 6165Substrate bindingBy similarity

Sequence similaritiesi

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66663-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAHLGMPV PVYMAEREED LALRKLIDTL KISAGWDLEA NRMAGRLYHF
60 70 80 90 100
VMGRRAPVDT RAYVTTFGDK LEKGVHRFLW DNARDIDDLC KDFQNGPEYE
110 120 130 140 150
RLISRGMLSA KRMYDTYVLR TEEGGGEGAV YESALQMYAR MAAFFTCQCF
160 170 180 190 200
AYPSLRKTVS EVEGGSGRME SGLDFFAYFF KILASQLVSC ATPVMRSAGL
210 220 230 240 250
RQSYLASCFI MNPDMSTEDK TLSAVFRDLS PLLCSKSGVG MNLTNFSSGG
260 270 280 290 300
KNVQSCLRLI NSQVEFCNDK NLRPVSVAAY MELWHEQIEE FLAAKLPENP
310 320 330 340 350
ERCQSIFQGV CVPGLFFRLY EQNPDSQWHL FSPKVGGHLA GLYGDKFDEE
360 370 380 390 400
YARLVRHGLY SSSLPAKSLM FALISAIIKT GSPYILSKDA INRHHWFETQ
410 420 430 440 450
GNAISYANLC AEVVQQPHEF TSTCNLANVC LPACLRARGE GEGAGAAGEG
460 470 480 490 500
EGADRLSPLT PDLEFCFDTL RAAVRAAVYM INASILGGVC PTPGVRVMQA
510 520 530 540 550
ERSAGIGVQG LADVFAKLGR GYMDAESALL DARIFEVMYY QAVRASNQLV
560 570 580 590 600
TVGGAPPHAN WKNSKLSRGE FHWESWGVQY DSLFIERQLW EELRESVTKH
610 620 630 640 650
GTFNSQFIAL MPTAGTSQLT GLSESFYPFY ANVSSKVSNK EEVMKPNITF
660 670 680 690 700
LERVSPSDVP LLKYHGGDVS KLPPPLAAKY RNFLTAFDYS PEDQIRRAAA
710 720 730 740 750
RSPFVDQSQS FSFFLKEANV KSASYVKNLI LLGHGLGLKT IMYYCRIQKQ
760 770 780 790
TSLTALECLQ CTESPDSGDG VGGYKGGDEE PRSPEHAQCE SPDRCLSCQ
Length:799
Mass (Da):88,581
Last modified:November 1, 1996 - v1
Checksum:iA88D2540357934F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20824 Genomic DNA. Translation: AAC13849.1.
PIRiS55656.
RefSeqiNP_042658.1. NC_001650.1.

Genome annotation databases

GeneIDi1461053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20824 Genomic DNA. Translation: AAC13849.1 .
PIRi S55656.
RefSeqi NP_042658.1. NC_001650.1.

3D structure databases

ProteinModelPortali Q66663.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1461053.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

InterProi IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view ]
PRINTSi PR01183. RIBORDTASEM1.
TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR1_EHV2
AccessioniPrimary (citable) accession number: Q66663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3