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Q66663

- RIR1_EHV2

UniProt

Q66663 - RIR1_EHV2

Protein

Ribonucleoside-diphosphate reductase large subunit

Gene

61

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei192 – 1921SubstrateBy similarity
    Sitei208 – 2081Important for hydrogen atom transferBy similarity
    Binding sitei238 – 2381Substrate; via amide nitrogenBy similarity
    Active sitei408 – 4081Proton acceptorBy similarity
    Active sitei410 – 4101Cysteine radical intermediateBy similarity
    Active sitei412 – 4121Proton acceptorBy similarity
    Sitei424 – 4241Important for hydrogen atom transferBy similarity
    Sitei743 – 7431Important for electron transferBy similarity
    Sitei744 – 7441Important for electron transferBy similarity
    Sitei795 – 7951Interacts with thioredoxin/glutaredoxinBy similarity
    Sitei798 – 7981Interacts with thioredoxin/glutaredoxinBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase large subunit (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase large subunit
    Gene namesi
    Name:61
    OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
    Taxonomic identifieri82831 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
    Virus hostiEquus caballus (Horse) [TaxID: 9796]
    ProteomesiUP000007083: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 799799Ribonucleoside-diphosphate reductase large subunitPRO_0000405987Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi208 ↔ 424Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Keywords - Developmental stagei

    Early protein

    Structurei

    3D structure databases

    ProteinModelPortaliQ66663.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni207 – 2082Substrate bindingBy similarity
    Regioni408 – 4125Substrate bindingBy similarity
    Regioni612 – 6165Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR013346. NrdE_NrdA.
    IPR000788. RNR_lg_C.
    IPR013509. RNR_lsu_N.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    PF00317. Ribonuc_red_lgN. 1 hit.
    [Graphical view]
    PRINTSiPR01183. RIBORDTASEM1.
    TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q66663-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAHLGMPV PVYMAEREED LALRKLIDTL KISAGWDLEA NRMAGRLYHF    50
    VMGRRAPVDT RAYVTTFGDK LEKGVHRFLW DNARDIDDLC KDFQNGPEYE 100
    RLISRGMLSA KRMYDTYVLR TEEGGGEGAV YESALQMYAR MAAFFTCQCF 150
    AYPSLRKTVS EVEGGSGRME SGLDFFAYFF KILASQLVSC ATPVMRSAGL 200
    RQSYLASCFI MNPDMSTEDK TLSAVFRDLS PLLCSKSGVG MNLTNFSSGG 250
    KNVQSCLRLI NSQVEFCNDK NLRPVSVAAY MELWHEQIEE FLAAKLPENP 300
    ERCQSIFQGV CVPGLFFRLY EQNPDSQWHL FSPKVGGHLA GLYGDKFDEE 350
    YARLVRHGLY SSSLPAKSLM FALISAIIKT GSPYILSKDA INRHHWFETQ 400
    GNAISYANLC AEVVQQPHEF TSTCNLANVC LPACLRARGE GEGAGAAGEG 450
    EGADRLSPLT PDLEFCFDTL RAAVRAAVYM INASILGGVC PTPGVRVMQA 500
    ERSAGIGVQG LADVFAKLGR GYMDAESALL DARIFEVMYY QAVRASNQLV 550
    TVGGAPPHAN WKNSKLSRGE FHWESWGVQY DSLFIERQLW EELRESVTKH 600
    GTFNSQFIAL MPTAGTSQLT GLSESFYPFY ANVSSKVSNK EEVMKPNITF 650
    LERVSPSDVP LLKYHGGDVS KLPPPLAAKY RNFLTAFDYS PEDQIRRAAA 700
    RSPFVDQSQS FSFFLKEANV KSASYVKNLI LLGHGLGLKT IMYYCRIQKQ 750
    TSLTALECLQ CTESPDSGDG VGGYKGGDEE PRSPEHAQCE SPDRCLSCQ 799
    Length:799
    Mass (Da):88,581
    Last modified:November 1, 1996 - v1
    Checksum:iA88D2540357934F0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20824 Genomic DNA. Translation: AAC13849.1.
    PIRiS55656.
    RefSeqiNP_042658.1. NC_001650.1.

    Genome annotation databases

    GeneIDi1461053.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20824 Genomic DNA. Translation: AAC13849.1 .
    PIRi S55656.
    RefSeqi NP_042658.1. NC_001650.1.

    3D structure databases

    ProteinModelPortali Q66663.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1461053.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    InterProi IPR013346. NrdE_NrdA.
    IPR000788. RNR_lg_C.
    IPR013509. RNR_lsu_N.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    PF00317. Ribonuc_red_lgN. 1 hit.
    [Graphical view ]
    PRINTSi PR01183. RIBORDTASEM1.
    TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRIR1_EHV2
    AccessioniPrimary (citable) accession number: Q66663
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3