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Q66662

- RIR2_EHV2

UniProt

Q66662 - RIR2_EHV2

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Protein
Ribonucleoside-diphosphate reductase small chain
Gene
60
Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron 1 By similarity
Metal bindingi94 – 941Iron 1 By similarity
Metal bindingi94 – 941Iron 2 By similarity
Metal bindingi97 – 971Iron 1 By similarity
Active sitei101 – 1011 By similarity
Metal bindingi157 – 1571Iron 2 By similarity
Metal bindingi191 – 1911Iron 2 By similarity
Metal bindingi194 – 1941Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. deoxyribonucleoside diphosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:60
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
ProteomesiUP000007083: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Ribonucleoside-diphosphate reductase small chain
PRO_0000405980Add
BLAST

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Heterodimer of a large and a small chain By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ66662.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q66662-1 [UniParc]FASTAAdd to Basket

« Hide

MDFVKQFLYS CDHMGFLALT QETWQNRWFP SQISLTSDVA CLQSLNPRDL    50
EFYKFLFSFL AMAEKLVNFN IQALVADFHS HDLEHYYTEQ EAMENIHGKV 100
YANILNMFFK NNVGEMQKYA REIVGDEALA AKLHWLHGRV SEAKTRAEKV 150
LVFLLIEGIF FISSFYSIAT LRVRGLMNGV CMANDYISRD EWVHTRAAAL 200
LFNTLVPDEE KPSPEWIGAL FREAVEVEYN FILAKGRGVS HVNVADINRF 250
LEATADRILK SINVGPVYGT QPPPNCPLVY TGCLKNVNFF ERESSDYTTA 300
VDNDL 305
Length:305
Mass (Da):34,926
Last modified:November 1, 1996 - v1
Checksum:iF1204390ED97B026
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20824 Genomic DNA. Translation: AAC13848.1.
PIRiS55655.
RefSeqiNP_042657.1. NC_001650.1.

Genome annotation databases

GeneIDi1461060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20824 Genomic DNA. Translation: AAC13848.1 .
PIRi S55655.
RefSeqi NP_042657.1. NC_001650.1.

3D structure databases

ProteinModelPortali Q66662.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1461060.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRIR2_EHV2
AccessioniPrimary (citable) accession number: Q66662
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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