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Q66662 (RIR2_EHV2) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:60
OrganismEquine herpesvirus 2 (strain 86/87) (EHV-2) [Reference proteome]
Taxonomic identifier82831 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostEquus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small chain By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Ribonucleoside-diphosphate reductase small chain
PRO_0000405980

Sites

Active site1011 By similarity
Metal binding641Iron 1 By similarity
Metal binding941Iron 1 By similarity
Metal binding941Iron 2 By similarity
Metal binding971Iron 1 By similarity
Metal binding1571Iron 2 By similarity
Metal binding1911Iron 2 By similarity
Metal binding1941Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q66662 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F1204390ED97B026

FASTA30534,926
        10         20         30         40         50         60 
MDFVKQFLYS CDHMGFLALT QETWQNRWFP SQISLTSDVA CLQSLNPRDL EFYKFLFSFL 

        70         80         90        100        110        120 
AMAEKLVNFN IQALVADFHS HDLEHYYTEQ EAMENIHGKV YANILNMFFK NNVGEMQKYA 

       130        140        150        160        170        180 
REIVGDEALA AKLHWLHGRV SEAKTRAEKV LVFLLIEGIF FISSFYSIAT LRVRGLMNGV 

       190        200        210        220        230        240 
CMANDYISRD EWVHTRAAAL LFNTLVPDEE KPSPEWIGAL FREAVEVEYN FILAKGRGVS 

       250        260        270        280        290        300 
HVNVADINRF LEATADRILK SINVGPVYGT QPPPNCPLVY TGCLKNVNFF ERESSDYTTA 


VDNDL 

« Hide

References

[1]"The DNA sequence of equine herpesvirus 2."
Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.
J. Mol. Biol. 249:520-528(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20824 Genomic DNA. Translation: AAC13848.1.
PIRS55655.
RefSeqNP_042657.1. NC_001650.1.

3D structure databases

ProteinModelPortalQ66662.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1461060.

Phylogenomic databases

ProtClustDBCLSP2509600.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_EHV2
AccessionPrimary (citable) accession number: Q66662
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways