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Q66662

- RIR2_EHV2

UniProt

Q66662 - RIR2_EHV2

Protein

Ribonucleoside-diphosphate reductase small chain

Gene

60

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi64 – 641Iron 1PROSITE-ProRule annotation
    Metal bindingi94 – 941Iron 1PROSITE-ProRule annotation
    Metal bindingi94 – 941Iron 2By similarity
    Metal bindingi97 – 971Iron 1PROSITE-ProRule annotation
    Active sitei101 – 1011PROSITE-ProRule annotation
    Metal bindingi157 – 1571Iron 2By similarity
    Metal bindingi191 – 1911Iron 2By similarity
    Metal bindingi194 – 1941Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:60
    OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
    Taxonomic identifieri82831 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
    Virus hostiEquus caballus (Horse) [TaxID: 9796]
    ProteomesiUP000007083: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Ribonucleoside-diphosphate reductase small chainPRO_0000405980Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Early protein

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small chain.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ66662.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q66662-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFVKQFLYS CDHMGFLALT QETWQNRWFP SQISLTSDVA CLQSLNPRDL    50
    EFYKFLFSFL AMAEKLVNFN IQALVADFHS HDLEHYYTEQ EAMENIHGKV 100
    YANILNMFFK NNVGEMQKYA REIVGDEALA AKLHWLHGRV SEAKTRAEKV 150
    LVFLLIEGIF FISSFYSIAT LRVRGLMNGV CMANDYISRD EWVHTRAAAL 200
    LFNTLVPDEE KPSPEWIGAL FREAVEVEYN FILAKGRGVS HVNVADINRF 250
    LEATADRILK SINVGPVYGT QPPPNCPLVY TGCLKNVNFF ERESSDYTTA 300
    VDNDL 305
    Length:305
    Mass (Da):34,926
    Last modified:November 1, 1996 - v1
    Checksum:iF1204390ED97B026
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20824 Genomic DNA. Translation: AAC13848.1.
    PIRiS55655.
    RefSeqiNP_042657.1. NC_001650.1.

    Genome annotation databases

    GeneIDi1461060.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20824 Genomic DNA. Translation: AAC13848.1 .
    PIRi S55655.
    RefSeqi NP_042657.1. NC_001650.1.

    3D structure databases

    ProteinModelPortali Q66662.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1461060.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRIR2_EHV2
    AccessioniPrimary (citable) accession number: Q66662
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3