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Q66656 (DUT_EHV2) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:54
OrganismEquine herpesvirus 2 (strain 86/87) (EHV-2) [Reference proteome]
Taxonomic identifier82831 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostEquus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000406053

Regions

Region176 – 1783Substrate binding By similarity

Sequences

Sequence LengthMass (Da)Tools
Q66656 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6FCEB405630FA996

FASTA28932,958
        10         20         30         40         50         60 
MTLRKQRQEI YYEFTSSSFE ITSPPESSKI TLTNLYPILV RPYVPAVIPL GIRIIYGNKG 

        70         80         90        100        110        120 
QGFILAGSSQ KKVFCHTGLI DPGYRGEIKL IVLNTTKYNV TLFAGELRVS LFSFFFSTPI 

       130        140        150        160        170        180 
IYDYDLLNRP QYSDDAGYDL YLQEDLMLFP QASTTVTIDS RVPTTTKFFK PVVFGRSGLA 

       190        200        210        220        230        240 
TRGVVVDVVK WTHSPLTLKI YNFTDNTLRY SAGTRICQVV FVHRRHFPSK LKHFFTYINL 

       250        260        270        280 
NSKTSFYWAN VSFVDCQNDA YRSLVTLPCQ EDTDRGYRGD SGFGSSGMR 

« Hide

References

[1]"The DNA sequence of equine herpesvirus 2."
Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.
J. Mol. Biol. 249:520-528(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20824 Genomic DNA. Translation: AAC13842.1.
PIRS55649.
RefSeqNP_042651.1. NC_001650.1.

3D structure databases

ProteinModelPortalQ66656.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1461068.

Phylogenomic databases

ProtClustDBPHA3131.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_EHV2
AccessionPrimary (citable) accession number: Q66656
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families