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Q66656

- DUT_EHV2

UniProt

Q66656 - DUT_EHV2

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

54

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:54
    OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
    Taxonomic identifieri82831 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
    Virus hostiEquus caballus (Horse) [TaxID: 9796]
    ProteomesiUP000007083: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000406053Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ66656.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni176 – 1783Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 3 hits.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 2 hits.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q66656-1 [UniParc]FASTAAdd to Basket

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    MTLRKQRQEI YYEFTSSSFE ITSPPESSKI TLTNLYPILV RPYVPAVIPL    50
    GIRIIYGNKG QGFILAGSSQ KKVFCHTGLI DPGYRGEIKL IVLNTTKYNV 100
    TLFAGELRVS LFSFFFSTPI IYDYDLLNRP QYSDDAGYDL YLQEDLMLFP 150
    QASTTVTIDS RVPTTTKFFK PVVFGRSGLA TRGVVVDVVK WTHSPLTLKI 200
    YNFTDNTLRY SAGTRICQVV FVHRRHFPSK LKHFFTYINL NSKTSFYWAN 250
    VSFVDCQNDA YRSLVTLPCQ EDTDRGYRGD SGFGSSGMR 289
    Length:289
    Mass (Da):32,958
    Last modified:November 1, 1996 - v1
    Checksum:i6FCEB405630FA996
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20824 Genomic DNA. Translation: AAC13842.1.
    PIRiS55649.
    RefSeqiNP_042651.1. NC_001650.1.

    Genome annotation databases

    GeneIDi1461068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20824 Genomic DNA. Translation: AAC13842.1 .
    PIRi S55649.
    RefSeqi NP_042651.1. NC_001650.1.

    3D structure databases

    ProteinModelPortali Q66656.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1461068.

    Family and domain databases

    Gene3Di 2.70.40.10. 3 hits.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_EHV2
    AccessioniPrimary (citable) accession number: Q66656
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3