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Protein

Cytoplasmic envelopment protein 3

Gene

38

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the cytoplasmic envelopment of tegument proteins and capsids during the assembly and egress processes. Participates also in viral entry at the fusion step probably by regulating the core fusion machinery.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic envelopment protein 3UniRule annotation
Gene namesi
Name:38
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000007083 Componenti: Genome

Subcellular locationi

Q66642:
  • Virion tegument UniRule annotation
  • Virion membrane UniRule annotation; Lipid-anchor UniRule annotation
  • Host cell membrane UniRule annotation; Lipid-anchor UniRule annotation; Cytoplasmic side UniRule annotation
  • Host Golgi apparatus membrane UniRule annotation; Lipid-anchor UniRule annotation; Cytoplasmic side UniRule annotation
  • Note: Virion membrane-associated tegument protein. Associates with host membrane lipids rafts. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; by hostUniRule annotation
ChainiPRO_00004060612 – 91Cytoplasmic envelopment protein 3UniRule annotationAdd BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine; by hostUniRule annotation1

Post-translational modificationi

Myristoylation and palmitoylation (probably on one or more of the nearby cysteines at the N-terminus) enable membrane-binding and Golgi apparatus-specific targeting and are essential for efficient packaging.UniRule annotation
Phosphorylated. Phosphorylation does not seem to be required for recycling to the host Golgi apparatus. Packaging is selective for underphosphorylated forms.UniRule annotation

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Interactioni

Subunit structurei

Interacts with cytoplasmic envelopment protein 2; this interaction is essential for the proper localization of each protein to the assembly complex and thus for the production of infectious virus.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae cytoplasmic envelopment protein 3 family.UniRule annotation

Family and domain databases

HAMAPiMF_04042. HSV_CEP3_gammahv. 1 hit.
InterProiView protein in InterPro
IPR024360. Herpesvirus_UL11_homo.
PfamiView protein in Pfam
PF10813. DUF2733. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q66642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILLSICRR RHDPLTDVEG QPINVREEFE MFEEGDEATE ACVFLNPNMG
60 70 80 90
TDEYDEEDEG GDGGEGREPQ PEVKTTPYPK RKKIKLKADV L
Length:91
Mass (Da):10,311
Last modified:November 1, 1996 - v1
Checksum:i1784D979FAA61F40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20824 Genomic DNA. Translation: AAC13826.1.
PIRiS55633.
RefSeqiNP_042635.1. NC_001650.2.

Genome annotation databases

GeneIDi1461043.
KEGGivg:1461043.

Similar proteinsi

Entry informationi

Entry nameiCEP3_EHV2
AccessioniPrimary (citable) accession number: Q66642
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 1, 1996
Last modified: January 18, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families