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Protein

Major capsid protein

Gene

MCP

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid proteinUniRule annotation
Short name:
MCPUniRule annotation
Gene namesi
Name:MCPUniRule annotation
Synonyms:25
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000007083 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=16 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004060331 – 1381Major capsid proteinAdd BLAST1381

Proteomic databases

PRIDEiQ66628

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2. Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus. Interacts with capsid vertex component 2/CVC2. Interacts with the small capsomere-interacting protein/SCP.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ66628
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae major capsid protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900000D

Family and domain databases

HAMAPiMF_04016 HSV_MCP, 1 hit
InterProiView protein in InterPro
IPR000912 Herpes_MCP
IPR023233 Herpes_MCP_upper_sf
PfamiView protein in Pfam
PF03122 Herpes_MCP, 1 hit
PRINTSiPR00235 HSVCAPSIDMCP
SUPFAMiSSF103417 SSF103417, 1 hit

Sequencei

Sequence statusi: Complete.

Q66628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPVAIENRP YPYFATEANL LKGIKESAAE GLFKSFQLLL GKDVRENGVK
60 70 80 90 100
FEVLLGVYSN VIQYIKFLET SLAVGCINTE FKDLRRMTNG KIQFKINVPT
110 120 130 140 150
IAHGDGRRPT KQRQYIVLKT ANKHHISTEM ELAVLDLEIL HSSQETALDV
160 170 180 190 200
TEYIGAVKTI TSALQFGVDA LERGLVDTVL HVKLRSAPPM FIYKTLNDPT
210 220 230 240 250
IVERGMKKTV KSDLVAMFKA HLVEHTFFLD KAQYASQSVQ YVMTMLSDMA
260 270 280 290 300
ATVCNETVFK GIASYTTPSG EVVDGVLETT DNVMRKLLAM LGQSGNSIVG
310 320 330 340 350
PASYASYVVR GDNLVTAVSY GRAMVAFDQF VSRLVDNPNA TPSSVEDDLN
360 370 380 390 400
AISSAAGLGQ QNRMAIPSSV IRVGDKTIAV ESLQNMYTEA QVPFPLNRRL
410 420 430 440 450
QYSYYFPVGL HMPKPKYSTS NVIRGAENPL YQPVEAWVVN KNNTLLRFDY
460 470 480 490 500
TCALRSLCHP KVHNPNPCAG ALQAAFPEAP ERMEAHGLEY EQPPHMNAHR
510 520 530 540 550
LMFDYYNGKN VAHVTHIARK TSMSTDDLLH PSAHELLKLE VHPLFDFYAV
560 570 580 590 600
GAPGARGVAY RATHRGMVGN IPQSLAPAGF QECRGDQFET AACLSHVVDA
610 620 630 640 650
ATIEVVQQSA FDPNYPVICY LIEAMVHGQE EKFVMNAQLI ALVIESYWTN
660 670 680 690 700
TGRLAFVNSF HMIKFICQHL GGAAVSKEVY GLYRRIYGEI VALEQALVKV
710 720 730 740 750
AGHDDINRRH VGEYTNSLLD PSLLPPFVYN NVFGAFFNRV DRHAEVHVGN
760 770 780 790 800
YAVDSYNDMA GILNVTDRME DLVGRFVNLY NNRVDDDHEH RFQLDVGVFR
810 820 830 840 850
DAENILVLEK IFYYVFLPVC TNGHVCGMGV DFNNLALALA YNGPVYAPAV
860 870 880 890 900
NGADPILDHL ENGTLRDLLQ ASDVAPTVDM IRTLATSFLT CPVNTQHARV
910 920 930 940 950
KTRRDPGQAV ATHERAKLVG QTLLVNGFAA FAISERNRPA CETMFFPVPF
960 970 980 990 1000
HKFYSDPMVA ATLQPMIADY VNQIPSQRDV LAFNVPPTIM AEYEEWHKSP
1010 1020 1030 1040 1050
MAQYARSCAP TPLSLSTMVC MHNKLSPVAF VNQAKNRIHP GFALTVVRTD
1060 1070 1080 1090 1100
EVLSENILYS SRASTSVFVG LPSVTRKEVR SDAVTFEIHH ELATLNTSLG
1110 1120 1130 1140 1150
YSSILVPAHV ASITTDMGVH CQDLFAMYPG EQFADREMHN YLKKKVGAAQ
1160 1170 1180 1190 1200
GQHNGPDARH LLNAGFACHG PPGLSHGQLA TCEVILTPVT ADVSYFQSSN
1210 1220 1230 1240 1250
SPRGRASCVV SCEPYNAESA ENFIYNHSLS DPAYEFRATV NPWASQLGSL
1260 1270 1280 1290 1300
GDVMYNASYK QMMAPGLYSP CRQFFNKEDL LKNNRGLYGL VNEYITRLGG
1310 1320 1330 1340 1350
APATSGTDLQ FVVINGTDVF LEQPCLFLQE AFPTLSASHR ALIDEYMSYK
1360 1370 1380
QTHAPVHFNQ HLIEEVAPVK RLFKQGNKLV Y
Length:1,381
Mass (Da):153,203
Last modified:November 1, 1996 - v1
Checksum:iD6CD6C9AEC555185
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20824 Genomic DNA Translation: AAC13812.1
PIRiS55619
RefSeqiNP_042621.1, NC_001650.2

Genome annotation databases

GeneIDi1461080
KEGGivg:1461080

Similar proteinsi

Entry informationi

Entry nameiMCP_EHV2
AccessioniPrimary (citable) accession number: Q66628
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health