Q66624 (KITH_EHV2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:

21

Organism

Equine herpesvirus 2 (strain 86/87) (EHV-2) [Reference proteome]

Taxonomic identifier

82831 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Percavirus › Equid herpesvirus 2

Virus host

Equus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length	613 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.
Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Sequence similarities	Belongs to the herpesviruses thymidine kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	TMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 613	613	Thymidine kinase		PRO_0000405986
Regions
	Nucleotide binding	301 – 308	8	ATP By similarity
	Compositional bias	9 – 15	7	Poly-Ser
Sites
	Active site	327	1	Proton acceptor By similarity
	Binding site	344	1	Substrate By similarity
	Binding site	365	1	Substrate By similarity
	Binding site	412	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q66624 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 406E222029510020	FASTA	613	68,679
	10 20 30 40 50 60 MAEGGAGFSS SSTSSEEAVP WSTQQPMGWE ELESLGDGGG STSADEEFQW EAMFVKSRAG 70 80 90 100 110 120 SPTAEDKSRT FTLPRGRPKN EPRPERGKGK TPKKPKKPDQ GATLLVGEEP RPRLGSRTRS 130 140 150 160 170 180 KSRSRDKHQL PDDIYDVPNP PMLAPVDSYG NPVEQVSSSE SDFEDIANIR PILRRQQPVT 190 200 210 220 230 240 VKHRREPSPE PLGHPTFVHR YDKPSYDEEV CQKKDKGGRT KSKNWLRQPG VKSKLTSMKD 250 260 270 280 290 300 LSGSFKSLMH IRSDGEKHKQ QQRPGGSGAP GGATPRDVFN TFLGSGTCPS FKNAFFLYLE 310 320 330 340 350 360 GSMGVGKTTL IRHMREINGD NVISFVEPMF YWREVYSDCV KLIYSACKPF NLGKMSTSKK 370 380 390 400 410 420 VLSAQMKFMT PMKCLQTSVR RYVKANEPLQ EKTAMDNWLL FDRHPLSATL VFPYLSLKNG 430 440 450 460 470 480 YLAFEHFLAL AANFTAHEGD IIALLCMGEE DNLKMVKLRN RKGESGVTSA HLKDLGQAFH 490 500 510 520 530 540 ACYCTWLLLK YLSPEDMVSV CCCDVTLNDI CIMRSMSSSK VTMAKSLFNK SMFPTLMDVI 550 560 570 580 590 600 QPFRSNCTII EICLTLFMEL KKVEFIVVNA SEFIGDIPGV WTSIYTQSLR TQAIKTQSID 610 WSGLRAFSLT YNS

References

[1]	"The DNA sequence of equine herpesvirus 2." Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J. J. Mol. Biol. 249:520-528(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U20824 Genomic DNA. Translation: AAC13808.1.
PIR	S55615.
RefSeq	NP_042617.1. NC_001650.1.
3D structure databases
HSSP	HSSP built from PDB template 1P72 based on UniProtKB P24425.
ProteinModelPortal	Q66624.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1461018.
Phylogenomic databases
ProtClustDB	PHA3132.
Family and domain databases
InterPro	IPR001889. Herpes_TK. IPR013672. Herpes_TK_C. [Graphical view]
Pfam	PF00693. Herpes_TK. 1 hit. PF08465. Herpes_TK_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_EHV2

Accession

Primary (citable) accession number: Q66624

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 8, 2011
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program