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Q66624 (KITH_EHV2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:21
OrganismEquine herpesvirus 2 (strain 86/87) (EHV-2) [Reference proteome]
Taxonomic identifier82831 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostEquus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length613 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 613613Thymidine kinase
PRO_0000405986

Regions

Nucleotide binding301 – 3088ATP By similarity
Compositional bias9 – 157Poly-Ser

Sites

Active site3271Proton acceptor By similarity
Binding site3441Substrate By similarity
Binding site3651Substrate By similarity
Binding site4121Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q66624 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 406E222029510020

FASTA61368,679
        10         20         30         40         50         60 
MAEGGAGFSS SSTSSEEAVP WSTQQPMGWE ELESLGDGGG STSADEEFQW EAMFVKSRAG 

        70         80         90        100        110        120 
SPTAEDKSRT FTLPRGRPKN EPRPERGKGK TPKKPKKPDQ GATLLVGEEP RPRLGSRTRS 

       130        140        150        160        170        180 
KSRSRDKHQL PDDIYDVPNP PMLAPVDSYG NPVEQVSSSE SDFEDIANIR PILRRQQPVT 

       190        200        210        220        230        240 
VKHRREPSPE PLGHPTFVHR YDKPSYDEEV CQKKDKGGRT KSKNWLRQPG VKSKLTSMKD 

       250        260        270        280        290        300 
LSGSFKSLMH IRSDGEKHKQ QQRPGGSGAP GGATPRDVFN TFLGSGTCPS FKNAFFLYLE 

       310        320        330        340        350        360 
GSMGVGKTTL IRHMREINGD NVISFVEPMF YWREVYSDCV KLIYSACKPF NLGKMSTSKK 

       370        380        390        400        410        420 
VLSAQMKFMT PMKCLQTSVR RYVKANEPLQ EKTAMDNWLL FDRHPLSATL VFPYLSLKNG 

       430        440        450        460        470        480 
YLAFEHFLAL AANFTAHEGD IIALLCMGEE DNLKMVKLRN RKGESGVTSA HLKDLGQAFH 

       490        500        510        520        530        540 
ACYCTWLLLK YLSPEDMVSV CCCDVTLNDI CIMRSMSSSK VTMAKSLFNK SMFPTLMDVI 

       550        560        570        580        590        600 
QPFRSNCTII EICLTLFMEL KKVEFIVVNA SEFIGDIPGV WTSIYTQSLR TQAIKTQSID 

       610 
WSGLRAFSLT YNS 

« Hide

References

[1]"The DNA sequence of equine herpesvirus 2."
Telford E.A.R., Watson M.S., Aird H.C., Perry J., Davison A.J.
J. Mol. Biol. 249:520-528(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20824 Genomic DNA. Translation: AAC13808.1.
PIRS55615.
RefSeqNP_042617.1. NC_001650.1.

3D structure databases

ProteinModelPortalQ66624.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1461018.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_EHV2
AccessionPrimary (citable) accession number: Q66624
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families