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Q66624

- KITH_EHV2

UniProt

Q66624 - KITH_EHV2

Protein

Thymidine kinase

Gene

21

Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei327 – 3271Proton acceptorBy similarity
    Binding sitei344 – 3441SubstrateBy similarity
    Binding sitei365 – 3651SubstrateBy similarity
    Binding sitei412 – 4121SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi301 – 3088ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:21
    OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
    Taxonomic identifieri82831 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
    Virus hostiEquus caballus (Horse) [TaxID: 9796]
    ProteomesiUP000007083: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 613613Thymidine kinasePRO_0000405986Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ66624.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi9 – 157Poly-Ser

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR013672. Herpes_TK_C.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    PF08465. Herpes_TK_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q66624-1 [UniParc]FASTAAdd to Basket

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    MAEGGAGFSS SSTSSEEAVP WSTQQPMGWE ELESLGDGGG STSADEEFQW    50
    EAMFVKSRAG SPTAEDKSRT FTLPRGRPKN EPRPERGKGK TPKKPKKPDQ 100
    GATLLVGEEP RPRLGSRTRS KSRSRDKHQL PDDIYDVPNP PMLAPVDSYG 150
    NPVEQVSSSE SDFEDIANIR PILRRQQPVT VKHRREPSPE PLGHPTFVHR 200
    YDKPSYDEEV CQKKDKGGRT KSKNWLRQPG VKSKLTSMKD LSGSFKSLMH 250
    IRSDGEKHKQ QQRPGGSGAP GGATPRDVFN TFLGSGTCPS FKNAFFLYLE 300
    GSMGVGKTTL IRHMREINGD NVISFVEPMF YWREVYSDCV KLIYSACKPF 350
    NLGKMSTSKK VLSAQMKFMT PMKCLQTSVR RYVKANEPLQ EKTAMDNWLL 400
    FDRHPLSATL VFPYLSLKNG YLAFEHFLAL AANFTAHEGD IIALLCMGEE 450
    DNLKMVKLRN RKGESGVTSA HLKDLGQAFH ACYCTWLLLK YLSPEDMVSV 500
    CCCDVTLNDI CIMRSMSSSK VTMAKSLFNK SMFPTLMDVI QPFRSNCTII 550
    EICLTLFMEL KKVEFIVVNA SEFIGDIPGV WTSIYTQSLR TQAIKTQSID 600
    WSGLRAFSLT YNS 613
    Length:613
    Mass (Da):68,679
    Last modified:November 1, 1996 - v1
    Checksum:i406E222029510020
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20824 Genomic DNA. Translation: AAC13808.1.
    PIRiS55615.
    RefSeqiNP_042617.1. NC_001650.1.

    Genome annotation databases

    GeneIDi1461018.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20824 Genomic DNA. Translation: AAC13808.1 .
    PIRi S55615.
    RefSeqi NP_042617.1. NC_001650.1.

    3D structure databases

    ProteinModelPortali Q66624.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1461018.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR013672. Herpes_TK_C.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    PF08465. Herpes_TK_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_EHV2
    AccessioniPrimary (citable) accession number: Q66624
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3