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Q66624

- KITH_EHV2

UniProt

Q66624 - KITH_EHV2

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Protein
Thymidine kinase
Gene
21
Organism
Equine herpesvirus 2 (strain 86/87) (EHV-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei327 – 3271Proton acceptor By similarity
Binding sitei344 – 3441Substrate By similarity
Binding sitei365 – 3651Substrate By similarity
Binding sitei412 – 4121Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi301 – 3088ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:21
OrganismiEquine herpesvirus 2 (strain 86/87) (EHV-2)
Taxonomic identifieri82831 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaePercavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
ProteomesiUP000007083: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613Thymidine kinase
PRO_0000405986Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ66624.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 157Poly-Ser

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66624-1 [UniParc]FASTAAdd to Basket

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MAEGGAGFSS SSTSSEEAVP WSTQQPMGWE ELESLGDGGG STSADEEFQW    50
EAMFVKSRAG SPTAEDKSRT FTLPRGRPKN EPRPERGKGK TPKKPKKPDQ 100
GATLLVGEEP RPRLGSRTRS KSRSRDKHQL PDDIYDVPNP PMLAPVDSYG 150
NPVEQVSSSE SDFEDIANIR PILRRQQPVT VKHRREPSPE PLGHPTFVHR 200
YDKPSYDEEV CQKKDKGGRT KSKNWLRQPG VKSKLTSMKD LSGSFKSLMH 250
IRSDGEKHKQ QQRPGGSGAP GGATPRDVFN TFLGSGTCPS FKNAFFLYLE 300
GSMGVGKTTL IRHMREINGD NVISFVEPMF YWREVYSDCV KLIYSACKPF 350
NLGKMSTSKK VLSAQMKFMT PMKCLQTSVR RYVKANEPLQ EKTAMDNWLL 400
FDRHPLSATL VFPYLSLKNG YLAFEHFLAL AANFTAHEGD IIALLCMGEE 450
DNLKMVKLRN RKGESGVTSA HLKDLGQAFH ACYCTWLLLK YLSPEDMVSV 500
CCCDVTLNDI CIMRSMSSSK VTMAKSLFNK SMFPTLMDVI QPFRSNCTII 550
EICLTLFMEL KKVEFIVVNA SEFIGDIPGV WTSIYTQSLR TQAIKTQSID 600
WSGLRAFSLT YNS 613
Length:613
Mass (Da):68,679
Last modified:November 1, 1996 - v1
Checksum:i406E222029510020
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20824 Genomic DNA. Translation: AAC13808.1.
PIRiS55615.
RefSeqiNP_042617.1. NC_001650.1.

Genome annotation databases

GeneIDi1461018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20824 Genomic DNA. Translation: AAC13808.1 .
PIRi S55615.
RefSeqi NP_042617.1. NC_001650.1.

3D structure databases

ProteinModelPortali Q66624.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1461018.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKITH_EHV2
AccessioniPrimary (citable) accession number: Q66624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3