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Q665U8

- UPPP_YERPS

UniProt

Q665U8 - UPPP_YERPS

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciYPSE273123:GI1M-3522-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA, upk
    Ordered Locus Names:YPTB3412
    OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
    Taxonomic identifieri273123 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000001011: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272Undecaprenyl-diphosphatasePRO_0000151247Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273123.YPTB3412.

    Structurei

    3D structure databases

    ProteinModelPortaliQ665U8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalUniRule annotationAdd
    BLAST
    Transmembranei45 – 6521HelicalUniRule annotationAdd
    BLAST
    Transmembranei88 – 10821HelicalUniRule annotationAdd
    BLAST
    Transmembranei114 – 13421HelicalUniRule annotationAdd
    BLAST
    Transmembranei153 – 17220HelicalUniRule annotationAdd
    BLAST
    Transmembranei189 – 20921HelicalUniRule annotationAdd
    BLAST
    Transmembranei221 – 24121HelicalUniRule annotationAdd
    BLAST
    Transmembranei251 – 27121HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiMEIGTIF.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q665U8-1 [UniParc]FASTAAdd to Basket

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    MTDMYSLFVA FILGVVEGLT EFLPVSSTGH MIIVGELLGF TGDKAKTFEV    50
    IIQLGSILAV VVVFWRRLFG LIGIHFGAVP HEGKTNGHLT LGHILLAMIP 100
    AVILGLAFHD VIKALFDPKS VMYALVAGGV LLLAAEWLKP KNPKAVGLDD 150
    ITYRQAFAIG CFQCLALWPG FSRSGATISG GMLVGVNRYA ASEFSFILAV 200
    PMMIGASGLD LYKSLHFLTL GDLPMFAVGF ITAFIVALIA IKTFLSLIKR 250
    ISFVPFAIYR FIVAAVVYWV FM 272
    Length:272
    Mass (Da):29,483
    Last modified:October 11, 2004 - v1
    Checksum:i164FC644788F2189
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX936398 Genomic DNA. Translation: CAH22650.1.
    RefSeqiYP_071901.1. NC_006155.1.

    Genome annotation databases

    EnsemblBacteriaiCAH22650; CAH22650; YPTB3412.
    GeneIDi2955268.
    KEGGiyps:YPTB3412.
    PATRICi18646132. VBIYerPse22266_4106.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX936398 Genomic DNA. Translation: CAH22650.1 .
    RefSeqi YP_071901.1. NC_006155.1.

    3D structure databases

    ProteinModelPortali Q665U8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273123.YPTB3412.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH22650 ; CAH22650 ; YPTB3412 .
    GeneIDi 2955268.
    KEGGi yps:YPTB3412.
    PATRICi 18646132. VBIYerPse22266_4106.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi MEIGTIF.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci YPSE273123:GI1M-3522-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IP32953.

    Entry informationi

    Entry nameiUPPP_YERPS
    AccessioniPrimary (citable) accession number: Q665U8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3