##gff-version 3 Q66575 UniProtKB Initiator methionine 1 1 . . . Note=Removed%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Chain 2 2193 . . . ID=PRO_0000426446;Note=Genome polyprotein Q66575 UniProtKB Chain 2 859 . . . ID=PRO_0000426447;Note=P1 Q66575 UniProtKB Chain 2 330 . . . ID=PRO_0000426448;Note=Capsid protein VP0 Q66575 UniProtKB Chain 2 69 . . . ID=PRO_0000426449;Note=Capsid protein VP4 Q66575 UniProtKB Chain 70 330 . . . ID=PRO_0000426450;Note=Capsid protein VP2 Q66575 UniProtKB Chain 331 568 . . . ID=PRO_0000426451;Note=Capsid protein VP3 Q66575 UniProtKB Chain 569 859 . . . ID=PRO_0000426452;Note=Capsid protein VP1 Q66575 UniProtKB Chain 860 1437 . . . ID=PRO_0000426453;Note=P2 Q66575 UniProtKB Chain 860 1009 . . . ID=PRO_0000426454;Note=Protease 2A Q66575 UniProtKB Chain 1010 1108 . . . ID=PRO_0000039719;Note=Protein 2B Q66575 UniProtKB Chain 1109 1437 . . . ID=PRO_0000039720;Note=Protein 2C Q66575 UniProtKB Chain 1438 2193 . . . ID=PRO_0000426455;Note=P3 Q66575 UniProtKB Chain 1438 1548 . . . ID=PRO_0000426456;Note=Protein 3AB Q66575 UniProtKB Chain 1438 1526 . . . ID=PRO_0000039721;Note=Protein 3A Q66575 UniProtKB Chain 1527 1548 . . . ID=PRO_0000426457;Note=Viral protein genome-linked Q66575 UniProtKB Chain 1549 2193 . . . ID=PRO_0000426458;Note=Protein 3CD Q66575 UniProtKB Chain 1549 1731 . . . ID=PRO_0000426459;Note=Protease 3C Q66575 UniProtKB Chain 1732 2193 . . . ID=PRO_0000426460;Note=RNA-directed RNA polymerase Q66575 UniProtKB Topological domain 2 1503 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q66575 UniProtKB Intramembrane 1504 1519 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q66575 UniProtKB Topological domain 1520 2193 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q66575 UniProtKB Domain 1213 1369 . . . Note=SF3 helicase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00551 Q66575 UniProtKB Domain 1549 1727 . . . Note=Peptidase C3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01222 Q66575 UniProtKB Domain 1958 2074 . . . Note=RdRp catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00539 Q66575 UniProtKB Zinc finger 1377 1394 . . . Note=C4-type%3B degenerate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9VUU3 Q66575 UniProtKB Region 565 582 . . . Note=Amphipathic alpha-helix;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q66575 UniProtKB Region 1109 1247 . . . Note=Oligomerization;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Region 1109 1181 . . . Note=Membrane-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Region 1130 1134 . . . Note=RNA-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Region 1421 1428 . . . Note=RNA-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Region 1432 1437 . . . Note=Oligomerization;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Active site 880 880 . . . Note=For protease 2A activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Active site 898 898 . . . Note=For protease 2A activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Active site 969 969 . . . Note=For protease 2A activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Active site 1588 1588 . . . Note=For protease 3C activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01222 Q66575 UniProtKB Active site 1619 1619 . . . Note=For protease 3C activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01222 Q66575 UniProtKB Active site 1695 1695 . . . Note=For protease 3C activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01222 Q66575 UniProtKB Binding site 915 915 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QF31 Q66575 UniProtKB Binding site 917 917 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QF31 Q66575 UniProtKB Binding site 975 975 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QF31 Q66575 UniProtKB Binding site 977 977 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9QF31 Q66575 UniProtKB Binding site 1377 1377 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9VUU3 Q66575 UniProtKB Binding site 1389 1389 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9VUU3 Q66575 UniProtKB Binding site 1394 1394 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B9VUU3 Q66575 UniProtKB Binding site 1964 1964 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Binding site 1964 1964 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Binding site 2060 2060 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Binding site 2060 2060 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Site 69 70 . . . Note=Cleavage%3B by autolysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Site 330 331 . . . Note=Cleavage%3B by protease 3C;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03301 Q66575 UniProtKB Site 859 860 . . . Note=Cleavage%3B by autolysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03301 Q66575 UniProtKB Site 1009 1010 . . . Note=Cleavage%3B by protease 3C;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03301 Q66575 UniProtKB Site 1108 1109 . . . Note=Cleavage%3B by protease 3C;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03301 Q66575 UniProtKB Site 1133 1133 . . . Note=Involved in the interaction with host RTN3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q66478 Q66575 UniProtKB Site 1437 1438 . . . Note=Cleavage%3B by protease 3C;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03301 Q66575 UniProtKB Site 1526 1527 . . . Note=Cleavage%3B by protease 3C;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03301 Q66575 UniProtKB Site 1548 1549 . . . Note=Cleavage%3B by protease 3C;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03301 Q66575 UniProtKB Site 1731 1732 . . . Note=Cleavage%3B by protease 3C;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03301 Q66575 UniProtKB Modified residue 1529 1529 . . . Note=O-(5'-phospho-RNA)-tyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Lipidation 2 2 . . . Note=N-myristoyl glycine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03300 Q66575 UniProtKB Natural variant 223 223 . . . Note=In rhodanine-resistant variant. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7637032;Dbxref=PMID:7637032 Q66575 UniProtKB Natural variant 228 228 . . . Note=In rhodanine-resistant variant. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7637032;Dbxref=PMID:7637032 Q66575 UniProtKB Natural variant 376 376 . . . Note=In rhodanine-resistant variant. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7637032;Dbxref=PMID:7637032 Q66575 UniProtKB Natural variant 643 643 . . . Note=In rhodanine-resistant variant. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7637032;Dbxref=PMID:7637032 Q66575 UniProtKB Natural variant 669 669 . . . Note=In rhodanine-resistant variant. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7637032;Dbxref=PMID:7637032 Q66575 UniProtKB Natural variant 725 725 . . . Note=In rhodanine-resistant variant. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7637032;Dbxref=PMID:7637032 Q66575 UniProtKB Natural variant 2094 2094 . . . Note=In rhodanine-resistant variant. C->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7637032;Dbxref=PMID:7637032