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Q663V5 (MTLD_YERPS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:YPTB3919
OrganismYersinia pseudotuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier633 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000011824

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q663V5 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: C110364E31E909F3

FASTA38741,992
        10         20         30         40         50         60 
MKALHFGAGN IGRGFIGKLL ADAGAQLTFA DVNQPLLDAL NKRKSYQVNV VGEQARVEEV 

        70         80         90        100        110        120 
KNVSAVNSGS PEVVALIAEA DIVTTAVGPQ ILARIAATVA QGLITRHQQG NTRPLNIIAC 

       130        140        150        160        170        180 
ENMVRGTSQL KQHVFAALSE DEQRWVEQHV GFVDSAVDRI VPPSEAGSTD ILAVTVETFS 

       190        200        210        220        230        240 
EWIVDGTQFK GQPPEIVGME LTDNLMAFVE RKLFTLNTGH AITAYLGQLA GHQTIRDAIL 

       250        260        270        280        290        300 
DPAVRQTVKG AMEESGAVLI KRYAFDPQKH AAYINKILSR FENPYLHDDV ERVGRQPLRK 

       310        320        330        340        350        360 
LSAGDRLIKP LLGTLEYQLP HDSLVTGIAA AMSYRSEQDP QAQELVTLLA QLGPKAALAQ 

       370        380 
ISDLPADSEV VEQAVSVYNA MQQKLAH

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References

[1]"Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis."
Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O., Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L., Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C., Simonet M., Chenal-Francisque V., Souza B. expand/collapse author list , Dacheux D., Elliott J.M., Derbise A., Hauser L.J., Garcia E.
Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004) [PubMed: 15358858] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IP32953 / Serotype I.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX936398 Genomic DNA. Translation: CAH23157.1.
RefSeqYP_072395.1. NC_006155.1.

3D structure databases

ProteinModelPortalQ663V5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2956090.
GenomeReviewsGene locus YPTB3919 in contig BX936398_GR.
KEGGyps:YPTB3919.
NMPDRfig|273123.1.peg.3977.
PATRIC18647315. VBIYerPse22266_4689.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG568825.
OMAFANTAVD.
ProtClustDBPRK02318.

Enzyme and pathway databases

BioCycYPSE273123:YPTB3919-MONOMER.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_YERPS
AccessionPrimary (citable) accession number: Q663V5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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