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Q663R1

- GLMS_YERPS

UniProt

Q663R1 - GLMS_YERPS

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei604 – 6041For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciYPSE273123:GI1M-4084-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:YPTB3964
OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
Taxonomic identifieri273123 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001011: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 609608Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135419Add
BLAST

Proteomic databases

PRIDEiQ663R1.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi273123.YPTB3964.

Structurei

3D structure databases

ProteinModelPortaliQ663R1.
SMRiQ663R1. Positions 2-609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini286 – 426141SIS 1UniRule annotationAdd
BLAST
Domaini458 – 599142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiFYTHAGP.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q663R1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGAVAQ RDIAEILIEG LRRLEYRGYD SAGLAVVDSE GHLTRLRRVG
60 70 80 90 100
KVHALSDAAE KQDLHGGTGI AHTRWATHGE PSEANAHPHV SDYISVVHNG
110 120 130 140 150
IIENHEPLRE LLISRGYRFS SETDTEVIAH LVHWEQQQGG SLLEVVKRVI
160 170 180 190 200
PQLRGAYGTV VMDSRDPSRL IAARSGSPLV IGCGVGENFI ASDQLALLPV
210 220 230 240 250
TRRFIFLEEG DVVEVTRRSI SIFDKQGNAI ERPEIESQVQ YDAGDKGIYR
260 270 280 290 300
HYMQKEIYEQ PMAIKNTLEG RLSHGMIDLS ELGPKADALL AEVQHIQIIA
310 320 330 340 350
CGTSYNSGMV SRYWFESLAG VPCDVEIASE FRYRKSAVRP NSLLITLSQS
360 370 380 390 400
GETADTLAAL RLSKELGYLG SLAICNVAGS SLVRESDLAL MTKAGTEIGV
410 420 430 440 450
ASTKAFTTQL TVLLMLVGRI GKLKGADASL EHDIVHALQA LPARIEQMLS
460 470 480 490 500
LDKTIEALAE GFSDKHHALF LGRGDQYPIA MEGALKLKEI SYIHAEAYAA
510 520 530 540 550
GELKHGPLAL IDADMPVIVV APNNELLEKL KSNIEEVRAR GGLLYVFADQ
560 570 580 590 600
DAGFTDSEGM KIIQLPHVEE IIAPIFYTVP LQLLSYHVAL IKGTDVDQPR

NLAKSVTVE
Length:609
Mass (Da):66,525
Last modified:January 23, 2007 - v3
Checksum:i3EB0B5ACEE758B7F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX936398 Genomic DNA. Translation: CAH23202.1.
RefSeqiYP_072439.1. NC_006155.1.

Genome annotation databases

EnsemblBacteriaiCAH23202; CAH23202; YPTB3964.
GeneIDi2955693.
KEGGiyps:YPTB3964.
PATRICi18647429. VBIYerPse22266_4746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX936398 Genomic DNA. Translation: CAH23202.1 .
RefSeqi YP_072439.1. NC_006155.1.

3D structure databases

ProteinModelPortali Q663R1.
SMRi Q663R1. Positions 2-609.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273123.YPTB3964.

Protein family/group databases

MEROPSi C44.971.

Proteomic databases

PRIDEi Q663R1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH23202 ; CAH23202 ; YPTB3964 .
GeneIDi 2955693.
KEGGi yps:YPTB3964.
PATRICi 18647429. VBIYerPse22266_4746.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi FYTHAGP.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci YPSE273123:GI1M-4084-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IP32953.

Entry informationi

Entry nameiGLMS_YERPS
AccessioniPrimary (citable) accession number: Q663R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3