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Q663R1

- GLMS_YERPS

UniProt

Q663R1 - GLMS_YERPS

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei604 – 6041For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciYPSE273123:GI1M-4084-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:YPTB3964
    OrganismiYersinia pseudotuberculosis serotype I (strain IP32953)
    Taxonomic identifieri273123 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000001011: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 609608Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135419Add
    BLAST

    Proteomic databases

    PRIDEiQ663R1.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi273123.YPTB3964.

    Structurei

    3D structure databases

    ProteinModelPortaliQ663R1.
    SMRiQ663R1. Positions 2-609.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini286 – 426141SIS 1UniRule annotationAdd
    BLAST
    Domaini458 – 599142SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258898.
    KOiK00820.
    OMAiFYTHAGP.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q663R1-1 [UniParc]FASTAAdd to Basket

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    MCGIVGAVAQ RDIAEILIEG LRRLEYRGYD SAGLAVVDSE GHLTRLRRVG    50
    KVHALSDAAE KQDLHGGTGI AHTRWATHGE PSEANAHPHV SDYISVVHNG 100
    IIENHEPLRE LLISRGYRFS SETDTEVIAH LVHWEQQQGG SLLEVVKRVI 150
    PQLRGAYGTV VMDSRDPSRL IAARSGSPLV IGCGVGENFI ASDQLALLPV 200
    TRRFIFLEEG DVVEVTRRSI SIFDKQGNAI ERPEIESQVQ YDAGDKGIYR 250
    HYMQKEIYEQ PMAIKNTLEG RLSHGMIDLS ELGPKADALL AEVQHIQIIA 300
    CGTSYNSGMV SRYWFESLAG VPCDVEIASE FRYRKSAVRP NSLLITLSQS 350
    GETADTLAAL RLSKELGYLG SLAICNVAGS SLVRESDLAL MTKAGTEIGV 400
    ASTKAFTTQL TVLLMLVGRI GKLKGADASL EHDIVHALQA LPARIEQMLS 450
    LDKTIEALAE GFSDKHHALF LGRGDQYPIA MEGALKLKEI SYIHAEAYAA 500
    GELKHGPLAL IDADMPVIVV APNNELLEKL KSNIEEVRAR GGLLYVFADQ 550
    DAGFTDSEGM KIIQLPHVEE IIAPIFYTVP LQLLSYHVAL IKGTDVDQPR 600
    NLAKSVTVE 609
    Length:609
    Mass (Da):66,525
    Last modified:January 23, 2007 - v3
    Checksum:i3EB0B5ACEE758B7F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX936398 Genomic DNA. Translation: CAH23202.1.
    RefSeqiYP_072439.1. NC_006155.1.

    Genome annotation databases

    EnsemblBacteriaiCAH23202; CAH23202; YPTB3964.
    GeneIDi2955693.
    KEGGiyps:YPTB3964.
    PATRICi18647429. VBIYerPse22266_4746.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX936398 Genomic DNA. Translation: CAH23202.1 .
    RefSeqi YP_072439.1. NC_006155.1.

    3D structure databases

    ProteinModelPortali Q663R1.
    SMRi Q663R1. Positions 2-609.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273123.YPTB3964.

    Protein family/group databases

    MEROPSi C44.971.

    Proteomic databases

    PRIDEi Q663R1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH23202 ; CAH23202 ; YPTB3964 .
    GeneIDi 2955693.
    KEGGi yps:YPTB3964.
    PATRICi 18647429. VBIYerPse22266_4746.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258898.
    KOi K00820.
    OMAi FYTHAGP.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci YPSE273123:GI1M-4084-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IP32953.

    Entry informationi

    Entry nameiGLMS_YERPS
    AccessioniPrimary (citable) accession number: Q663R1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 73 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3