Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q662C3 (GLPK_BORGA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:BG0244
OrganismBorrelia garinii [Complete proteome] [HAMAP]
Taxonomic identifier29519 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Glycerol kinase HAMAP MF_00186
PRO_1000020705

Regions

Nucleotide binding409 – 4135ATP By similarity

Sites

Binding site111Substrate By similarity
Binding site151ATP By similarity
Binding site811Substrate By similarity
Binding site1331Substrate By similarity
Binding site2421Substrate By similarity
Binding site2641ATP By similarity
Binding site3071ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q662C3 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 31CF9CD08FA9DF29

FASTA50155,707
        10         20         30         40         50         60 
MKYILSIDQG TTSSRAIVFD KHANIKGLAQ KEFTQIYPQP SWVEHDPTEI WGSQLGVITE 

        70         80         90        100        110        120 
ALANSRILPN EVDAIGITNQ RETTVIWEKS TGKPIYNAIV WQDRRTAKIC DQLTKEGKDK 

       130        140        150        160        170        180 
IILEKTGLVL DSYFSGTKIL WILDNVEGAR QKAENGELCF GTIDTWLLWN LTQKKVHATD 

       190        200        210        220        230        240 
YSNASRTLLL NIKTLEWDDE LLKILNIPKA ILPELKESST IYGETDKSIF GAEIPIAGIA 

       250        260        270        280        290        300 
GDQFAATFGQ ACLKKGMAKN TYGTGCFLTV NIGKEPIINH ERLLTSIAWG RKKTVTYVLE 

       310        320        330        340        350        360 
GSVFIGGAVI QWLRDGLEFF RKSSDAESLA SSASDNGGVY FVPAFVGLGA PHWDSYARGT 

       370        380        390        400        410        420 
IIGITRGSTK AHITRAALES IAFQSFDILN TMKKSIPNFE IKELRVDGGA SQNNLLMQFQ 

       430        440        450        460        470        480 
ADLLECKVVR PKITETTALG AAYLAGLASG YWQSAEEIIS LWQVDKIFEP SMPKNQKEKL 

       490        500 
LENWNRAIER SKSWIQNSNS L

« Hide

References

[1]"Comparative analysis of the Borrelia garinii genome."
Gloeckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U., Schilhabel M., Wilske B., Suehnel J., Platzer M.
Nucleic Acids Res. 32:6038-6046(2004) [PubMed: 15547252] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PBi.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000013 Genomic DNA. Translation: AAU07098.1.
RefSeqYP_072690.1. NC_006156.1.

3D structure databases

HSSPHSSP built from PDB template 1GLC based on UniProtKB P0A6F3.
ProteinModelPortalQ662C3.
SMRQ662C3. Positions 2-499.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000008092; EBBORP00000007467; EBBORG00000008091.
GeneID2957503.
GenomeReviewsGene locus BG0244 in contig CP000013_GR.
KEGGbga:BG0244.
PATRIC20566043. VBIBorGar102262_0348.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000006825.
HOGENOMHBG511469.
OMAFHWSINA.
PhylomeDBQ662C3.
ProtClustDBCLSK507458.

Enzyme and pathway databases

BioCycBGAR290434:BG0244-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_BORGA
AccessionPrimary (citable) accession number: Q662C3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents