Reviewed,
UniProtKB/Swiss-Prot Q662C3 (GLPK_BORGA)
Last modified
February 9, 2010.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Glycerol kinase EC=2.7.1.30 Alternative name(s): ATP:glycerol 3-phosphotransferase Glycerokinase Short name=GK | ||||
| Gene names |
| ||||
| Organism | Borrelia garinii [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 29519 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group |
Protein attributes
| Sequence length | 501 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186 |
| Catalytic activity | ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186 |
| Pathway | Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186 |
| Sequence similarities | Belongs to the FGGY kinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycerol metabolism |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: HAMAP |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP glycerol kinase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 501 | 501 | Glycerol kinase HAMAP MF_00186 | PRO_1000020705 | |||||
Regions | |||||||||
| Nucleotide binding | 409 – 413 | 5 | ATP By similarity | ||||||
Sites | |||||||||
| Binding site | 11 | 1 | Substrate By similarity | ||||||
| Binding site | 15 | 1 | ATP By similarity | ||||||
| Binding site | 81 | 1 | Substrate By similarity | ||||||
| Binding site | 133 | 1 | Substrate By similarity | ||||||
| Binding site | 242 | 1 | Substrate By similarity | ||||||
| Binding site | 264 | 1 | ATP By similarity | ||||||
| Binding site | 307 | 1 | ATP; via carbonyl oxygen By similarity | ||||||
Sequences
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References
| [1] | "Comparative analysis of the Borrelia garinii genome." Gloeckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U., Schilhabel M., Wilske B., Suehnel J., Platzer M. Nucleic Acids Res. 32:6038-6046(2004) [PubMed: 15547252] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PBi. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000013 Genomic DNA. Translation: AAU07098.1. |
| RefSeq | YP_072690.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GLC based on UniProtKB P0A6F3. |
| SMR | Q662C3. Positions 2-499. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2957503. |
| GenomeReviews | Gene locus BG0244 in contig CP000013_GR. |
| KEGG | bga:BG0244. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG511469. |
| OMA | IPNIDAE. |
| PhylomeDB | Q662C3. |
Enzyme and pathway databases | |
| BioCyc | BGAR290434:BG0244-MONOMER. |
| BRENDA | 2.7.1.30. 294970. |
Family and domain databases | |
| HAMAP | MF_00186. Glycerol_kin. [Tree] |
| InterPro | IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view] |
| PANTHER | PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit. |
| Pfam | PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01311. glycerol_kin. 1 hit. |
| PROSITE | PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GLPK_BORGA | ||||||||
| Accession | Primary (citable) accession number: Q662C3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


