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Q662B4

- SYL_BORGA

UniProt

Q662B4 - SYL_BORGA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borrelia garinii (strain PBi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei620 – 6201ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBGAR290434:BG0254-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BG0254
    OrganismiBorrelia garinii (strain PBi)
    Taxonomic identifieri290434 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000002276: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 840840Leucine--tRNA ligasePRO_0000151980Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290434.BG0254.

    Structurei

    3D structure databases

    ProteinModelPortaliQ662B4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi44 – 5512"HIGH" regionAdd
    BLAST
    Motifi617 – 6215"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q662B4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKYEFIKIE KKWQEFWDNN KTYKVKEDPN IPKEKRLYIL DMFPYPSANG    50
    LHVGHPEGYT ATDIFGRYKL LNGFHVLHPI GFDSFGLPAE NYAIQTGTHP 100
    QKSTEENINK FKKQIKALGF AYDWDREIRT HDENYYKWTQ WIFLELYKKG 150
    LAYAKEMPVW YCPELGTVLA NEEIIQTPDG PKSERGFHNV EKKYLRQWVL 200
    KITKYAERLL NDLEELEWPE SVKEMQRNWI GKSTGVEIDF EIEGHNDKIK 250
    VFTTRPDTIF GITYLVIAPE SKLIEKITKN NFKRNVLKYV KHEELKSDLK 300
    RTSLEKDKSG VFTGSYAFHP ITNEKIPIWI GSYVLGTYGS GAVMGVPAHD 350
    ERDFQFAKKY KLKILPVISK SGKNEILEKA FIDDGISINS PNEFNNLKNS 400
    EVKDKVIEWL IKNKKGKEKV TYKLRDWIFS RQRYWGEPIP ILFDKLGNAV 450
    PLEKNDLPLK LPKTANYKPS RTGESPLSRI KDWVNLKDTG FTRETNTMPQ 500
    WAGSCWYYLR YLDPKNPKEF ASKKKIEYWM PVDLYIGGAE HTVLHLLYSR 550
    FWHKVLYDLG YVNTKEPFKK LINQGIITAF SYQKENGILI PNDQVIEKNS 600
    KFFDKRDNKE VIQVIAKMSK SLKNVINPDD IIKEFGADSI RIYEMFMGPL 650
    TDSKPWNTKG IIGVFRFLNK IWNLREKELS KDNPPKEIIS QLHKAIKKVT 700
    EDTEKLSFNT AISAMMIFVN ELIKYEKNYL NIFKPFIIIL SPYAPHLAEE 750
    LWEYIGETPS LFKNSKWPEF DENLIIKDAK EIVLQINGKM KDKILLSKET 800
    DEEELKEIAM GNSKIKANLL NKKIVKIIAI KNKLVNIVIK 840
    Length:840
    Mass (Da):98,168
    Last modified:October 11, 2004 - v1
    Checksum:i20A9FBE916589685
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000013 Genomic DNA. Translation: AAU07107.1.
    RefSeqiYP_072699.1. NC_006156.1.

    Genome annotation databases

    EnsemblBacteriaiAAU07107; AAU07107; BG0254.
    GeneIDi2957256.
    KEGGibga:BG0254.
    PATRICi20566065. VBIBorGar102262_0358.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000013 Genomic DNA. Translation: AAU07107.1 .
    RefSeqi YP_072699.1. NC_006156.1.

    3D structure databases

    ProteinModelPortali Q662B4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290434.BG0254.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU07107 ; AAU07107 ; BG0254 .
    GeneIDi 2957256.
    KEGGi bga:BG0254.
    PATRICi 20566065. VBIBorGar102262_0358.

    Phylogenomic databases

    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BGAR290434:BG0254-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PBi.

    Entry informationi

    Entry nameiSYL_BORGA
    AccessioniPrimary (citable) accession number: Q662B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3