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Q662B4

- SYL_BORGA

UniProt

Q662B4 - SYL_BORGA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borrelia garinii (strain PBi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei620 – 6201ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBGAR290434:BG0254-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BG0254
OrganismiBorrelia garinii (strain PBi)
Taxonomic identifieri290434 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000002276: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 840840Leucine--tRNA ligasePRO_0000151980Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290434.BG0254.

Structurei

3D structure databases

ProteinModelPortaliQ662B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5512"HIGH" regionAdd
BLAST
Motifi617 – 6215"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q662B4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKYEFIKIE KKWQEFWDNN KTYKVKEDPN IPKEKRLYIL DMFPYPSANG
60 70 80 90 100
LHVGHPEGYT ATDIFGRYKL LNGFHVLHPI GFDSFGLPAE NYAIQTGTHP
110 120 130 140 150
QKSTEENINK FKKQIKALGF AYDWDREIRT HDENYYKWTQ WIFLELYKKG
160 170 180 190 200
LAYAKEMPVW YCPELGTVLA NEEIIQTPDG PKSERGFHNV EKKYLRQWVL
210 220 230 240 250
KITKYAERLL NDLEELEWPE SVKEMQRNWI GKSTGVEIDF EIEGHNDKIK
260 270 280 290 300
VFTTRPDTIF GITYLVIAPE SKLIEKITKN NFKRNVLKYV KHEELKSDLK
310 320 330 340 350
RTSLEKDKSG VFTGSYAFHP ITNEKIPIWI GSYVLGTYGS GAVMGVPAHD
360 370 380 390 400
ERDFQFAKKY KLKILPVISK SGKNEILEKA FIDDGISINS PNEFNNLKNS
410 420 430 440 450
EVKDKVIEWL IKNKKGKEKV TYKLRDWIFS RQRYWGEPIP ILFDKLGNAV
460 470 480 490 500
PLEKNDLPLK LPKTANYKPS RTGESPLSRI KDWVNLKDTG FTRETNTMPQ
510 520 530 540 550
WAGSCWYYLR YLDPKNPKEF ASKKKIEYWM PVDLYIGGAE HTVLHLLYSR
560 570 580 590 600
FWHKVLYDLG YVNTKEPFKK LINQGIITAF SYQKENGILI PNDQVIEKNS
610 620 630 640 650
KFFDKRDNKE VIQVIAKMSK SLKNVINPDD IIKEFGADSI RIYEMFMGPL
660 670 680 690 700
TDSKPWNTKG IIGVFRFLNK IWNLREKELS KDNPPKEIIS QLHKAIKKVT
710 720 730 740 750
EDTEKLSFNT AISAMMIFVN ELIKYEKNYL NIFKPFIIIL SPYAPHLAEE
760 770 780 790 800
LWEYIGETPS LFKNSKWPEF DENLIIKDAK EIVLQINGKM KDKILLSKET
810 820 830 840
DEEELKEIAM GNSKIKANLL NKKIVKIIAI KNKLVNIVIK
Length:840
Mass (Da):98,168
Last modified:October 11, 2004 - v1
Checksum:i20A9FBE916589685
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000013 Genomic DNA. Translation: AAU07107.1.
RefSeqiYP_072699.1. NC_006156.1.

Genome annotation databases

EnsemblBacteriaiAAU07107; AAU07107; BG0254.
GeneIDi2957256.
KEGGibga:BG0254.
PATRICi20566065. VBIBorGar102262_0358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000013 Genomic DNA. Translation: AAU07107.1 .
RefSeqi YP_072699.1. NC_006156.1.

3D structure databases

ProteinModelPortali Q662B4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290434.BG0254.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU07107 ; AAU07107 ; BG0254 .
GeneIDi 2957256.
KEGGi bga:BG0254.
PATRICi 20566065. VBIBorGar102262_0358.

Phylogenomic databases

HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BGAR290434:BG0254-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PBi.

Entry informationi

Entry nameiSYL_BORGA
AccessioniPrimary (citable) accession number: Q662B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 11, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3