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Q662A7

- UPPP_BORGA

UniProt

Q662A7 - UPPP_BORGA

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, bacA, BG0261
Organism
Borrelia garinii (strain PBi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBGAR290434:BG0261-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA
Ordered Locus Names:BG0261
OrganismiBorrelia garinii (strain PBi)
Taxonomic identifieri290434 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000002276: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Reviewed prediction
Add
BLAST
Transmembranei39 – 5921Helical; Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Reviewed prediction
Add
BLAST
Transmembranei112 – 13221Helical; Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Transmembranei184 – 20421Helical; Reviewed prediction
Add
BLAST
Transmembranei212 – 23221Helical; Reviewed prediction
Add
BLAST
Transmembranei246 – 26621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Undecaprenyl-diphosphataseUniRule annotation
PRO_0000151115Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290434.BG0261.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000218357.
KOiK06153.
OMAiVIYFRNE.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q662A7-1 [UniParc]FASTAAdd to Basket

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MINILNAIIL GIVQGITEFL PISSSGHLLL FRHFMHLKLP IIFDIYLHLA    50
TVLVIIIYYR QRILELFLTF IRFSLRKTNK SDLTNLKLIL LILIITIVTG 100
VVGTFISKYE RMFILPFILI NFIITGILIL MLEFNFFKID FKGNILLVGI 150
FIGLMQGLGA FPGISRSGIT IFSAVSLGFN RKSAFEISFL SLIPIVFGAI 200
LFKYKEFYDI FMVLNFFEIN LGALVAFVVG IISINFFFKM LNNKKLYYFS 250
IYLFALSITF CCFFRI 266
Length:266
Mass (Da):30,609
Last modified:October 11, 2004 - v1
Checksum:i2AAEA804F63821E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000013 Genomic DNA. Translation: AAU07114.1.
RefSeqiYP_072706.1. NC_006156.1.

Genome annotation databases

EnsemblBacteriaiAAU07114; AAU07114; BG0261.
GeneIDi2957365.
KEGGibga:BG0261.
PATRICi20566079. VBIBorGar102262_0365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000013 Genomic DNA. Translation: AAU07114.1 .
RefSeqi YP_072706.1. NC_006156.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 290434.BG0261.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU07114 ; AAU07114 ; BG0261 .
GeneIDi 2957365.
KEGGi bga:BG0261.
PATRICi 20566079. VBIBorGar102262_0365.

Phylogenomic databases

HOGENOMi HOG000218357.
KOi K06153.
OMAi VIYFRNE.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BGAR290434:BG0261-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PBi.

Entry informationi

Entry nameiUPPP_BORGA
AccessioniPrimary (citable) accession number: Q662A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi