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Q661V4

- NADK_BORGA

UniProt

Q661V4 - NADK_BORGA

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Protein

NAD kinase

Gene

nadK

Organism
Borrelia garinii (strain PBi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Proton acceptorUniRule annotation
Binding sitei149 – 1491NADUniRule annotation
Binding sitei166 – 1661NADUniRule annotation
Binding sitei168 – 1681NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 622NADUniRule annotation
Nucleotide bindingi138 – 1392NADUniRule annotation
Nucleotide bindingi179 – 1846NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciBGAR290434:BG0314-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:BG0314
OrganismiBorrelia garinii (strain PBi)
Taxonomic identifieri290434 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000002276: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279NAD kinasePRO_0000229616Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290434.BG0314.

Structurei

3D structure databases

ProteinModelPortaliQ661V4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000221177.
KOiK00858.
OMAiFPRENFL.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q661V4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSKALLCIN TLKSGAGILG DDIKVYLETK HFVEVVLIDV SKPLLSFPRE
60 70 80 90 100
NFLFLITLGG DGTVLLAVNL LLENKNVDIP IISINMGKVG FLADIKIEDF
110 120 130 140 150
KKVIDRFFKN SLVINKKFLL HVTVYKHGKD LISRYALNDI IIRSSLLNKM
160 170 180 190 200
IHVDLKVNSE NFLSYKSDGI IVSTPTGSTG YSFSAGGPIL EAELEGFLLT
210 220 230 240 250
PISPHSVYNR SFVFSKLSKL SLSFSKEYFI APASIFLDGI NFGSFGVDVV
260 270
FEFEISSQSL NFVSFCTDTF VKRLKNKLL
Length:279
Mass (Da):31,039
Last modified:October 11, 2004 - v1
Checksum:i5EAE535A897D1BC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000013 Genomic DNA. Translation: AAU07167.1.
RefSeqiYP_072759.1. NC_006156.1.

Genome annotation databases

EnsemblBacteriaiAAU07167; AAU07167; BG0314.
GeneIDi2957418.
KEGGibga:BG0314.
PATRICi20566185. VBIBorGar102262_0418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000013 Genomic DNA. Translation: AAU07167.1 .
RefSeqi YP_072759.1. NC_006156.1.

3D structure databases

ProteinModelPortali Q661V4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290434.BG0314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU07167 ; AAU07167 ; BG0314 .
GeneIDi 2957418.
KEGGi bga:BG0314.
PATRICi 20566185. VBIBorGar102262_0418.

Phylogenomic databases

HOGENOMi HOG000221177.
KOi K00858.
OMAi FPRENFL.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci BGAR290434:BG0314-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PBi.

Entry informationi

Entry nameiNADK_BORGA
AccessioniPrimary (citable) accession number: Q661V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3