Q661V4 (PPNK_BORGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	BG0314

Organism

Borrelia garinii [Complete proteome] [HAMAP]

Taxonomic identifier

29519 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000229616

Sequences

	Sequence		Length	Mass (Da)
	Q661V4 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 5EAE535A897D1BC5	FASTA	279	31,039
	10 20 30 40 50 60 MKSKALLCIN TLKSGAGILG DDIKVYLETK HFVEVVLIDV SKPLLSFPRE NFLFLITLGG 70 80 90 100 110 120 DGTVLLAVNL LLENKNVDIP IISINMGKVG FLADIKIEDF KKVIDRFFKN SLVINKKFLL 130 140 150 160 170 180 HVTVYKHGKD LISRYALNDI IIRSSLLNKM IHVDLKVNSE NFLSYKSDGI IVSTPTGSTG 190 200 210 220 230 240 YSFSAGGPIL EAELEGFLLT PISPHSVYNR SFVFSKLSKL SLSFSKEYFI APASIFLDGI 250 260 270 NFGSFGVDVV FEFEISSQSL NFVSFCTDTF VKRLKNKLL

References

[1]

"Comparative analysis of the Borrelia garinii genome." Gloeckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U., Schilhabel M., Wilske B., Suehnel J., Platzer M. Nucleic Acids Res. 32:6038-6046(2004) [PubMed: 15547252] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PBi.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000013 Genomic DNA. Translation: AAU07167.1.
RefSeq	YP_072759.1. NC_006156.1.
3D structure databases
ProteinModelPortal	Q661V4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000008054; EBBORP00000007429; EBBORG00000008053.
GeneID	2957418.
GenomeReviews	Gene locus BG0314 in contig CP000013_GR.
KEGG	bga:BG0314.
PATRIC	20566185. VBIBorGar102262_0418.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000007040.
HOGENOM	HBG354411.
OMA	CINTLKS.
PhylomeDB	Q661V4.
ProtClustDB	CLSK507507.
Enzyme and pathway databases
BioCyc	BGAR290434:BG0314-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_BORGA

Accession

Primary (citable) accession number: Q661V4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program