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Q661V4

- NADK_BORGA

UniProt

Q661V4 - NADK_BORGA

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Protein

NAD kinase

Gene
nadK, BG0314
Organism
Borrelia garinii (strain PBi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Proton acceptor By similarity
Binding sitei149 – 1491NAD By similarity
Binding sitei166 – 1661NAD By similarity
Binding sitei168 – 1681NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 622NAD By similarity
Nucleotide bindingi138 – 1392NAD By similarity
Nucleotide bindingi179 – 1846NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciBGAR290434:BG0314-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:BG0314
OrganismiBorrelia garinii (strain PBi)
Taxonomic identifieri290434 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000002276: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279NAD kinaseUniRule annotationPRO_0000229616Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290434.BG0314.

Structurei

3D structure databases

ProteinModelPortaliQ661V4.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

HOGENOMiHOG000221177.
KOiK00858.
OMAiFPRENFL.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q661V4-1 [UniParc]FASTAAdd to Basket

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MKSKALLCIN TLKSGAGILG DDIKVYLETK HFVEVVLIDV SKPLLSFPRE    50
NFLFLITLGG DGTVLLAVNL LLENKNVDIP IISINMGKVG FLADIKIEDF 100
KKVIDRFFKN SLVINKKFLL HVTVYKHGKD LISRYALNDI IIRSSLLNKM 150
IHVDLKVNSE NFLSYKSDGI IVSTPTGSTG YSFSAGGPIL EAELEGFLLT 200
PISPHSVYNR SFVFSKLSKL SLSFSKEYFI APASIFLDGI NFGSFGVDVV 250
FEFEISSQSL NFVSFCTDTF VKRLKNKLL 279
Length:279
Mass (Da):31,039
Last modified:October 11, 2004 - v1
Checksum:i5EAE535A897D1BC5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000013 Genomic DNA. Translation: AAU07167.1.
RefSeqiYP_072759.1. NC_006156.1.

Genome annotation databases

EnsemblBacteriaiAAU07167; AAU07167; BG0314.
GeneIDi2957418.
KEGGibga:BG0314.
PATRICi20566185. VBIBorGar102262_0418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000013 Genomic DNA. Translation: AAU07167.1 .
RefSeqi YP_072759.1. NC_006156.1.

3D structure databases

ProteinModelPortali Q661V4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290434.BG0314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU07167 ; AAU07167 ; BG0314 .
GeneIDi 2957418.
KEGGi bga:BG0314.
PATRICi 20566185. VBIBorGar102262_0418.

Phylogenomic databases

HOGENOMi HOG000221177.
KOi K00858.
OMAi FPRENFL.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci BGAR290434:BG0314-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PBi.

Entry informationi

Entry nameiNADK_BORGA
AccessioniPrimary (citable) accession number: Q661V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi