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Q661P2

- LUXS_BORGA

UniProt

Q661P2 - LUXS_BORGA

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Protein
S-ribosylhomocysteine lyase
Gene
luxS, BG0376
Organism
Borrelia garinii (strain PBi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity.UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Binds 1 iron ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Iron By similarity
Metal bindingi57 – 571Iron By similarity
Metal bindingi124 – 1241Iron By similarity

GO - Molecular functioni

  1. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: InterPro

GO - Biological processi

  1. quorum sensing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Autoinducer synthesis, Quorum sensing

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciBGAR290434:BG0376-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyase (EC:4.4.1.21)
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene namesi
Name:luxS
Ordered Locus Names:BG0376
OrganismiBorrelia garinii (strain PBi)
Taxonomic identifieri290434 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000002276: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157S-ribosylhomocysteine lyaseUniRule annotation
PRO_0000172213Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi290434.BG0376.

Structurei

3D structure databases

ProteinModelPortaliQ661P2.

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.

Phylogenomic databases

HOGENOMiHOG000040372.
KOiK07173.
OMAiDLISWLF.
OrthoDBiEOG68WRBM.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamiPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

Q661P2-1 [UniParc]FASTAAdd to Basket

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MKKITSFTID HTKLNPGIYV SRKDTFENVI FTTIDIRIKA PNIEPIIENA    50
AIHTIEHIGA TLLRNNEVWT EKIVYFGPMG CRTGFYLIIF GNYESKDLID 100
LISWLFSEIV NFSEPIPGAS HKECGNYKDH NLDMAKYESS KYLQILNNIK 150
EENLKYP 157
Length:157
Mass (Da):18,133
Last modified:October 11, 2004 - v1
Checksum:i86CD6AAC33AE2453
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000013 Genomic DNA. Translation: AAU07229.1.
RefSeqiYP_072821.1. NC_006156.1.

Genome annotation databases

EnsemblBacteriaiAAU07229; AAU07229; BG0376.
GeneIDi2957157.
KEGGibga:BG0376.
PATRICi20566313. VBIBorGar102262_0482.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000013 Genomic DNA. Translation: AAU07229.1 .
RefSeqi YP_072821.1. NC_006156.1.

3D structure databases

ProteinModelPortali Q661P2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290434.BG0376.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU07229 ; AAU07229 ; BG0376 .
GeneIDi 2957157.
KEGGi bga:BG0376.
PATRICi 20566313. VBIBorGar102262_0482.

Phylogenomic databases

HOGENOMi HOG000040372.
KOi K07173.
OMAi DLISWLF.
OrthoDBi EOG68WRBM.

Enzyme and pathway databases

BioCyci BGAR290434:BG0376-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.80. 1 hit.
HAMAPi MF_00091. LuxS.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view ]
Pfami PF02664. LuxS. 1 hit.
[Graphical view ]
PIRSFi PIRSF006160. AI2. 1 hit.
PRINTSi PR01487. LUXSPROTEIN.
ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63411. SSF63411. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PBi.

Entry informationi

Entry nameiLUXS_BORGA
AccessioniPrimary (citable) accession number: Q661P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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