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Reviewed, UniProtKB/Swiss-Prot Q661F0 (LSPA_BORGA)

Last modified February 9, 2010. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Lipoprotein signal peptidase
    EC=3.4.23.36
Alternative name(s):
    Prolipoprotein signal peptidase
    Signal peptidase II
      Short name=SPase II
Gene names
Name: lspA
Ordered Locus Names: BG0482
OrganismBorrelia garinii [Complete proteome] [HAMAP]
Taxonomic identifier29519 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

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Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity. HAMAP MF_00161

Catalytic activity

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP MF_00161

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP MF_00161

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00161.

Sequence similarities

Belongs to the peptidase A8 family.

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Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
   Molecular functionAspartyl protease
Hydrolase
Protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: HAMAP

   Molecular functionaspartic-type endopeptidase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Lipoprotein signal peptidase HAMAP MF_00161
PRO_0000289356

Regions

Transmembrane9 – 2921 Potential
Transmembrane72 – 9221 Potential
Transmembrane95 – 11723 Potential
Transmembrane143 – 16321 Potential

Sites

Active site1141 By similarity
Active site1461 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q661F0-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 03FCC1CB634972B8

FASTA17019,891
        10         20         30         40         50         60 
MGAKSKQYFN IFVFVISLIF FDQLSKYLVV KYVKLGSIYF SFFDNFFRII HVRNTGILFS 

        70         80         90        100        110        120 
MGSDIHYSLK KIFFIAMPIF ILIFVFSLAL KEKNCITRIS LLLIFSGGVG NIIDRLFRPS 

       130        140        150        160        170 
GVVDFLDFKF YGIFGLDRWP TFNFADSYVV IGMILFLVYD FFIKRKVLNT

« Hide

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References

[1]"Comparative analysis of the Borrelia garinii genome."
Gloeckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U., Schilhabel M., Wilske B., Suehnel J., Platzer M.
Nucleic Acids Res. 32:6038-6046(2004) [PubMed: 15547252] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PBi.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000013 Genomic DNA. Translation: AAU07321.1.
RefSeqYP_072913.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

MEROPSA08.001.

Genome annotation databases

GeneID2957974.
GenomeReviewsGene locus BG0482 in contig CP000013_GR.
KEGGbga:BG0482.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG724422.
OMAKYLVVKY.

Enzyme and pathway databases

BioCycBGAR290434:BG0482-MONOMER.
BRENDA3.4.23.36. 294970.

Family and domain databases

HAMAPMF_00161. LspA.
[Tree]
InterProIPR001872. Peptidase_A8.
[Graphical view]
PfamPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSPR00781. LIPOSIGPTASE.
TIGRFAMsTIGR00077. lspA. 1 hit.
PROSITEPS00855. SPASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLSPA_BORGA
AccessionPrimary (citable) accession number: Q661F0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2004
Last modified: February 9, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents