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Protein

Suppressor of silencing 2b

Gene

ORF2b

Organism
Cucumber mosaic virus (strain Q) (CMV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May directly interfere with the mobile silencing signal.2 Publications

Keywordsi

Molecular functionSuppressor of RNA silencing

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of silencing 2b
Alternative name(s):
Protein 2b
Gene namesi
ORF Names:ORF2b
OrganismiCucumber mosaic virus (strain Q) (CMV)
Taxonomic identifieri12310 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageBromoviridaeCucumovirus
Virus hostiCucumis sativus (Cucumber) [TaxID: 3659]
Nicotiana tabacum (Common tobacco) [TaxID: 4097]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Proteomesi
  • UP000008454 Componenti: Genome

Subcellular locationi

  • Host nucleus 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23 – 25RRR → QAQ: 70% loss of nuclear localization. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000832841 – 100Suppressor of silencing 2bAdd BLAST100

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 27Nuclear localization signal6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 27Poly-Arg5

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG09000357.

Family and domain databases

InterProiView protein in InterPro
IPR004946. Cucumo_2B.
PfamiView protein in Pfam
PF03263. Cucumo_2B. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009131. Cucumo_2B. 1 hit.

Sequencei

Sequence statusi: Complete.

Q66125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLTVVVST ADLHLANLQE VKRRRRRSHV RNRRARGYKS PSERARSIAR
60 70 80 90 100
LFQMLPFHGV DPVDWFPDVV RSPSVTSLVS YESFDDTDWF AGNEWAEGSF
Length:100
Mass (Da):11,580
Last modified:November 1, 1996 - v1
Checksum:i90838CD2411D6552
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21863 Genomic RNA. Translation: CAA79918.1.
PIRiB49598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21863 Genomic RNA. Translation: CAA79918.1.
PIRiB49598.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG09000357.

Family and domain databases

InterProiView protein in InterPro
IPR004946. Cucumo_2B.
PfamiView protein in Pfam
PF03263. Cucumo_2B. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009131. Cucumo_2B. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei2B_CMVQ
AccessioniPrimary (citable) accession number: Q66125
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1996
Last modified: March 15, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.