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Protein

RNA silencing suppressor p19

Gene

ORF4

Organism
Carnation Italian ringspot virus (CIRV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to short interfering RNAs (siRNAs) with high affinity. Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA.2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding, Suppressor of RNA silencing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA silencing suppressor p19
Alternative name(s):
19 kDa symptom severity modulator
Gene namesi
ORF Names:ORF4
OrganismiCarnation Italian ringspot virus (CIRV)
Taxonomic identifieri39443 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostiDianthus caryophyllus (Carnation) (Clove pink) [TaxID: 3570]
Proteomesi
  • UP000201384 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39W → G: Complete loss of silencing suppression. 1 Publication1
Mutagenesisi42W → G: Complete loss of silencing suppression. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002228721 – 172RNA silencing suppressor p19Add BLAST172

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 17Combined sources8
Beta strandi29 – 32Combined sources4
Helixi39 – 45Combined sources7
Beta strandi57 – 65Combined sources9
Beta strandi68 – 75Combined sources8
Helixi80 – 86Combined sources7
Helixi87 – 89Combined sources3
Helixi92 – 100Combined sources9
Beta strandi109 – 116Combined sources8
Beta strandi119 – 126Combined sources8
Helixi127 – 129Combined sources3
Helixi130 – 145Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RPUX-ray2.50A/B1-172[»]
ProteinModelPortaliQ66104
SMRiQ66104
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ66104

Family & Domainsi

Sequence similaritiesi

Belongs to the tombusvirus protein p19 family.Curated

Family and domain databases

Gene3Di2.60.40.1810, 1 hit
InterProiView protein in InterPro
IPR004905 Tombusvirus_p19
IPR036131 VP19_sf
PfamiView protein in Pfam
PF03220 Tombus_P19, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005743 Tombus_P19, 1 hit
SUPFAMiSSF103145 SSF103145, 1 hit

Sequencei

Sequence statusi: Complete.

Q66104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERAIQGNDT REQANGERWD GGSGGITSPF KLPDESPSWT EWRLYNDETN
60 70 80 90 100
SNQDNPLGFK ESWGFGKVVF KRYLRYDRTE ASLHRVLGSW TGDSVNYAAS
110 120 130 140 150
RFLGANQVGC TYSIRFRGVS VTISGGSRTL QHLCEMAIRS KQELLQLTPV
160 170
EVESNVSRGC PEGIETFKKE SE
Length:172
Mass (Da):19,335
Last modified:November 1, 1996 - v1
Checksum:iEF81C6386E06C3C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85215 Genomic RNA Translation: CAA59481.1
RefSeqiNP_612584.1, NC_003500.2

Genome annotation databases

GeneIDi935442
KEGGivg:935442

Similar proteinsi

Entry informationi

Entry nameiP19_CIRV
AccessioniPrimary (citable) accession number: Q66104
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

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