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Q660A8 (MURG_BORGA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:BG0790
OrganismBorrelia garinii [Complete proteome] [HAMAP]
Taxonomic identifier29519 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_0000225034

Sequences

Sequence LengthMass (Da)Tools
Q660A8 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 95DBB4B807530411

FASTA36341,499
        10         20         30         40         50         60 
MSNKKRIFFT GGGTGGHVFP GISIIQKLKE LDNEIEFFWI GKKNSIEEKL IKEQNNIKFI 

        70         80         90        100        110        120 
WVPCGKLRRY FSFQNFTDFF KVILGIIKSF YVLKKYKPQI VYATGGFVST PTIIASSLLK 

       130        140        150        160        170        180 
IKRITHEMDL DPGLATKINS KFANKIYTSF KESEKYFKNH KNIIYTGSPI RKEFLTPNPK 

       190        200        210        220        230        240 
IIKQLTQNTN KPIVSVLGGS LGANALNNLA LFIKKYAEIY FIHQSGKNLN DLREDNYLRR 

       250        260        270        280        290        300 
QFFNAEEMAS IEKFSNIIIS RAGAGAIKEF ANACTCVILI PFKKGSRGDQ IKNAKLLKNQ 

       310        320        330        340        350        360 
NACIYIDEDE ILNTNILKVI KETLNDREKI NSLKENIKKF NNKHSSTLIA KLLIEDIKET 


KSK

« Hide

References

[1]"Comparative analysis of the Borrelia garinii genome."
Gloeckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U., Schilhabel M., Wilske B., Suehnel J., Platzer M.
Nucleic Acids Res. 32:6038-6046(2004) [PubMed: 15547252] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PBi.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000013 Genomic DNA. Translation: AAU07613.1.
RefSeqYP_073205.1. NC_006156.1.

3D structure databases

ProteinModelPortalQ660A8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000007876; EBBORP00000007251; EBBORG00000007875.
GeneID2957493.
GenomeReviewsGene locus BG0790 in contig CP000013_GR.
KEGGbga:BG0790.
PATRIC20567153. VBIBorGar102262_0874.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007289.
HOGENOMHBG617076.
OMAHICGKGN.
PhylomeDBQ660A8.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycBGAR290434:BG0790-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_BORGA
AccessionPrimary (citable) accession number: Q660A8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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