Reviewed, UniProtKB/Swiss-Prot Q660A6 (GCP_BORGA)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	BG0792

Organism

Borrelia garinii [Complete proteome] [HAMAP]

Taxonomic identifier

29519 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303289
Sites
	Metal binding	110	1	Zinc Potential
	Metal binding	114	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q660A6-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 12FBAF4BA3DA0F8C	FASTA	338	37,772
	10 20 30 40 50 60 MKVLGIETSC DDCCIAVVEN GIHILSNIKL NQKEHKKYYG VVPEIASRLH TEAIMSVCIK 70 80 90 100 110 120 ALKKANTKIS EIDLIAVTSR PGLIGSLIVG LNFAKGLAIS LKKPIICIDH ILAHLYAPLM 130 140 150 160 170 180 SSKIEYPFIS LLLSGGHTLI AKQKNFDDVE ILGKTLDDSC GEAFDKVAKH YNMGFPGGPN 190 200 210 220 230 240 IEQISKNGDE NTFKFPVTTF RKKENWYDFS YSGLKTACIH QLEKFKSKDN PTTKNNIAAS 250 260 270 280 290 300 FQKAAFENLI TPLRRAIKDT QINKLVIAGG VASNLYLREK INKLKIQTYY PPLDLCTDNG 310 320 330 AMIAGLGFNM YLKYGESPIE TDVNSRIENY KNQYRRRK

References

[1]

"Comparative analysis of the Borrelia garinii genome." Gloeckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U., Schilhabel M., Wilske B., Suehnel J., Platzer M. Nucleic Acids Res. 32:6038-6046(2004) [PubMed: 15547252] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PBi.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000013 Genomic DNA. Translation: AAU07615.1.
RefSeq	YP_073207.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	2957312.
GenomeReviews	Gene locus BG0792 in contig CP000013_GR.
KEGG	bga:BG0792.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q660A6.
OMA	CKRALKQ.
Enzyme and pathway databases
BioCyc	BGAR290434:BG0792-MON.
BRENDA	3.4.24.57. 294970.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_BORGA

Accession

Primary (citable) accession number: Q660A6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)