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Q66096

- RDRP_CRSVL

UniProt

Q66096 - RDRP_CRSVL

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Protein
RNA-directed RNA polymerase
Gene
ORF1
Organism
Carnation ringspot virus (isolate Lommel) (CRSV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Probable polymerase.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
Protein p88
Gene namesi
ORF Names:ORF1
OrganismiCarnation ringspot virus (isolate Lommel) (CRSV)
Taxonomic identifieri652597 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeDianthovirus
Virus hostiDianthus barbatus [TaxID: 278075]
Dianthus caryophyllus (Carnation) (Clove pink) [TaxID: 3570]
ProteomesiUP000000574: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 769769RNA-directed RNA polymerase
PRO_0000398304Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ66096.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini463 – 579117RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF00998. RdRP_3. 1 hit.
[Graphical view]
PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

Isoform 88 kDa protein (identifier: Q66096-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAIFELFSFD IDKLLVWVSK FSPGKILSAI CRLGLDSWNN FRKWFWGLNF    50
DKHEWAVDHF MPLMPRFSSD MDEVAKRIVT PKSKPKLEDC LEIDTAVEEC 100
FNEECFEPQE DGSMKLKRVA APQQIKRVRT GMIEDAISAV EARIRNRHMI 150
MGDDMGLVDE AAVRATAMDI CGEYKINEHH TRCIIYAAAY RAMTPDQESI 200
DATKMAYNPK SQARRDLVSI LRKNISFGGF KSLEDFLSAP VSFPVEDAPY 250
QILGIPEIKV ADKRASRVCK FKRVVGLPSL SAGQSVCVHK TSLHNMIVSL 300
EQRVFRVKNE TGEFVVPPQP SKGAFDSISY FREAWKKKLY SKGPVVKSSI 350
DDVVACYSSE KKKLYQKGAA TLSHRPLHWR DSKVRAFIKV EKLECDKKAP 400
VPRTIQPRSK RYNLCIGRYL RLNEKRMLDA IDAVFGEKTV LSGLDNKAQG 450
RAIAKKWSKY ESPIGIGLDA SRFDQHCSKD ALKFEHSFYR ECFPDDKTSP 500
DLLDWQLENE GSALMPTESL VKYRTRCRMS GDINTGLGNK ILMCSMVHAY 550
LKEVGVNASL ANNGDDCVLF CEKGDFNRIN DSLREWFLCR GFNMVVEEPV 600
ECLERVVFCR SQPVCVATKW AMVRQLGSLS RDCFSTQNWL NPTTFRDAMN 650
ALGQCNGIIN DGVPVHMAQA KRMYAAGGNR KFDLKALHKQ MEYSWRDRLG 700
ARTNLLWSEV EDSTRLSYFR AFGIEPAVQR IVEGYFSESK ISEEGRQTNF 750
LPTHYSRLHK DLLVPRYLN 769

Note: Produced by ribosomal frameshifting between codons 236 and 237.

Length:769
Mass (Da):87,776
Last modified:October 5, 2010 - v2
Checksum:i0B9FBFD6D28949AA
GO
Isoform protein p27 (identifier: Q66096-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-767: Missing.

Note: Produced by conventional translation.

Show »
Length:238
Mass (Da):27,386
Checksum:i02A1E8922B798705
GO

Sequence cautioni

The sequence AAA20212.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei237 – 767531Missing in isoform protein p27.
VSP_039744Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L18870 Genomic RNA. Translation: AAA20211.1.
L18870 Genomic RNA. Translation: AAA20212.1. Sequence problems.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L18870 Genomic RNA. Translation: AAA20211.1 .
L18870 Genomic RNA. Translation: AAA20212.1 . Sequence problems.

3D structure databases

ProteinModelPortali Q66096.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view ]
Pfami PF00998. RdRP_3. 1 hit.
[Graphical view ]
PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of carnation ringspot dianthovirus RNA-1."
    Ryabov E.V., Generozov E.V., Kendall T.L., Lommel S.A., Zavriev S.K.
    J. Gen. Virol. 75:243-247(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Sit T.L., Lommel S.A.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_CRSVL
AccessioniPrimary (citable) accession number: Q66096
Secondary accession number(s): Q66097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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