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Q66096

- RDRP_CRSVL

UniProt

Q66096 - RDRP_CRSVL

Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Carnation ringspot virus (isolate Lommel) (CRSV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Probable polymerase.

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    Protein p88
    Gene namesi
    ORF Names:ORF1
    OrganismiCarnation ringspot virus (isolate Lommel) (CRSV)
    Taxonomic identifieri652597 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeDianthovirus
    Virus hostiDianthus barbatus [TaxID: 278075]
    Dianthus caryophyllus (Carnation) (Clove pink) [TaxID: 3570]
    ProteomesiUP000000574: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 769769RNA-directed RNA polymerasePRO_0000398304Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ66096.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini463 – 579117RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

    Isoform 88 kDa protein (identifier: Q66096-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAIFELFSFD IDKLLVWVSK FSPGKILSAI CRLGLDSWNN FRKWFWGLNF    50
    DKHEWAVDHF MPLMPRFSSD MDEVAKRIVT PKSKPKLEDC LEIDTAVEEC 100
    FNEECFEPQE DGSMKLKRVA APQQIKRVRT GMIEDAISAV EARIRNRHMI 150
    MGDDMGLVDE AAVRATAMDI CGEYKINEHH TRCIIYAAAY RAMTPDQESI 200
    DATKMAYNPK SQARRDLVSI LRKNISFGGF KSLEDFLSAP VSFPVEDAPY 250
    QILGIPEIKV ADKRASRVCK FKRVVGLPSL SAGQSVCVHK TSLHNMIVSL 300
    EQRVFRVKNE TGEFVVPPQP SKGAFDSISY FREAWKKKLY SKGPVVKSSI 350
    DDVVACYSSE KKKLYQKGAA TLSHRPLHWR DSKVRAFIKV EKLECDKKAP 400
    VPRTIQPRSK RYNLCIGRYL RLNEKRMLDA IDAVFGEKTV LSGLDNKAQG 450
    RAIAKKWSKY ESPIGIGLDA SRFDQHCSKD ALKFEHSFYR ECFPDDKTSP 500
    DLLDWQLENE GSALMPTESL VKYRTRCRMS GDINTGLGNK ILMCSMVHAY 550
    LKEVGVNASL ANNGDDCVLF CEKGDFNRIN DSLREWFLCR GFNMVVEEPV 600
    ECLERVVFCR SQPVCVATKW AMVRQLGSLS RDCFSTQNWL NPTTFRDAMN 650
    ALGQCNGIIN DGVPVHMAQA KRMYAAGGNR KFDLKALHKQ MEYSWRDRLG 700
    ARTNLLWSEV EDSTRLSYFR AFGIEPAVQR IVEGYFSESK ISEEGRQTNF 750
    LPTHYSRLHK DLLVPRYLN 769

    Note: Produced by ribosomal frameshifting between codons 236 and 237.

    Length:769
    Mass (Da):87,776
    Last modified:October 5, 2010 - v2
    Checksum:i0B9FBFD6D28949AA
    GO
    Isoform protein p27 (identifier: Q66096-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         237-767: Missing.

    Note: Produced by conventional translation.

    Show »
    Length:238
    Mass (Da):27,386
    Checksum:i02A1E8922B798705
    GO

    Sequence cautioni

    The sequence AAA20212.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei237 – 767531Missing in isoform protein p27. CuratedVSP_039744Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L18870 Genomic RNA. Translation: AAA20211.1.
    L18870 Genomic RNA. Translation: AAA20212.1. Sequence problems.

    Keywords - Coding sequence diversityi

    Ribosomal frameshifting

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L18870 Genomic RNA. Translation: AAA20211.1 .
    L18870 Genomic RNA. Translation: AAA20212.1 . Sequence problems.

    3D structure databases

    ProteinModelPortali Q66096.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of carnation ringspot dianthovirus RNA-1."
      Ryabov E.V., Generozov E.V., Kendall T.L., Lommel S.A., Zavriev S.K.
      J. Gen. Virol. 75:243-247(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. Sit T.L., Lommel S.A.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_CRSVL
    AccessioniPrimary (citable) accession number: Q66096
    Secondary accession number(s): Q66097
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 35 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3