Reviewed, UniProtKB/Swiss-Prot Q65ZZ7 (APT_BORGA)

Names and origin

Protein names

Recommended name:
    Adenine phosphoribosyltransferase
      Short name=APRT
    EC=2.4.2.7

Gene names

Name:	apt
Ordered Locus Names:	BG0801

Organism

Borrelia garinii [Complete proteome] [HAMAP]

Taxonomic identifier

29519 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. HAMAP MF_00004
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity. HAMAP MF_00004
Subcellular location	Cytoplasm HAMAP MF_00004.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: HAMAP purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Adenine phosphoribosyltransferase HAMAP MF_00004		PRO_0000149360

Sequences

	Sequence		Length	Mass (Da)
	Q65ZZ7-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 2DCB9DC5F1023DA2	FASTA	176	20,150
	10 20 30 40 50 60 MKNKTEYYDQ FIAKVPDFPK KGVLFYDITS VLLKPEVYTS LINEAYSFYN LKKIDCIAVV 70 80 90 100 110 120 ESRGYLIGAP LSLKMQLPLV LIRKEGKLPR EVFGEEYELE YGFGKIEVHK DDVRMYSNIL 130 140 150 160 170 LIDDILATGG TLKSSAILLE RAGGRVKDIF CFIELCGING RRILEDYDVN SLVRYN

References

[1]

"Comparative analysis of the Borrelia garinii genome." Gloeckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U., Schilhabel M., Wilske B., Suehnel J., Platzer M. Nucleic Acids Res. 32:6038-6046(2004) [PubMed: 15547252] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PBi.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000013 Genomic DNA. Translation: AAU07624.1.
RefSeq	YP_073216.1.
3D structure databases
SMR	Q65ZZ7. Positions 9-176.
ModBase	Search...
Genome annotation databases
GeneID	2957397.
GenomeReviews	Gene locus BG0801 in contig CP000013_GR.
KEGG	bga:BG0801.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG703830.
OMA	IRSIPDY.
Enzyme and pathway databases
BioCyc	BGAR290434:BG0801-MONOMER.
BRENDA	2.4.2.7. 294970.
Family and domain databases
HAMAP	MF_00004. Aden_phosphoribosyltr. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_BORGA

Accession

Primary (citable) accession number: Q65ZZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 11, 2004
Last modified:	January 19, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)