Reviewed, UniProtKB/Swiss-Prot Q65ZT0 (OTCC_BORGA)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase, catabolic
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	BG0869

Organism

Borrelia garinii [Complete proteome] [HAMAP]

Taxonomic identifier

29519 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000112891
Regions
	Region	56 – 60	5	Carbamoyl phosphate binding By similarity
	Region	268 – 271	4	Ornithine binding By similarity
Sites
	Binding site	107	1	Carbamoyl phosphate By similarity
	Binding site	134	1	Carbamoyl phosphate By similarity
	Site	31	1	Important for structural integrity By similarity
	Site	147	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65ZT0-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 894756DD1D570D6F	FASTA	327	36,479
	10 20 30 40 50 60 MYNLRNRSFL NLLDFTSKDI RYLLDLSIDL KKSKYAGIEV QKLKGKNMAI IFEKDSTRTR 70 80 90 100 110 120 CAFEIAAYDQ GANITYLGSR GNQIGVKESM MDTARVLGRM YDAIGFRGFS QQTVECLANY 130 140 150 160 170 180 SNVPVYNGLT DTAHPTQILA DLMPIEEHKG SLKGVKIVFC GDGRGNVANS LLKGCAIMGL 190 200 210 220 230 240 DFRIFAPKEL FPDSNLTLKA KSLALDSGGK ITITDSKEEA VKCADVVYTD VWVSMGENNW 250 260 270 280 290 300 EDRINLLRFY QVNKEIMDMA KDSAIFMHCL PAFHDLNTVV GKDIFDKYGI NGIEVTEEIF 310 320 ESKNSVVFDI AENRVHTIKA IVVATLG

References

[1]

"Comparative analysis of the Borrelia garinii genome." Gloeckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U., Schilhabel M., Wilske B., Suehnel J., Platzer M. Nucleic Acids Res. 32:6038-6046(2004) [PubMed: 15547252] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PBi.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000013 Genomic DNA. Translation: AAU07691.1.
RefSeq	YP_073283.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2957777.
GenomeReviews	Gene locus BG0869 in contig CP000013_GR.
KEGG	bga:BG0869.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q65ZT0.
OMA	NPNVKFM.
Enzyme and pathway databases
BioCyc	BGAR290434:BG0869-MON.
BRENDA	2.1.3.3. 294970.
Family and domain databases
HAMAP	MF_01109. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_BORGA

Accession

Primary (citable) accession number: Q65ZT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)