ID   Q65ZC9_HUMAN            Unreviewed;       240 AA.
AC   Q65ZC9;
DT   11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Single-chain Fv {ECO:0000313|EMBL:CAA73499.1};
DE   Flags: Fragment;
GN   Name=scFv {ECO:0000313|EMBL:CAA73499.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAA73499.1};
RN   [1] {ECO:0000313|EMBL:CAA73499.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C1q/7 {ECO:0000313|EMBL:CAA73499.1};
RX   PubMed=9219263; DOI=10.1038/nbt0797-629;
RA   Kontermann R.E., Wing M.G., Winter G.;
RT   "Complement recruitment using bispecific diabodies.";
RL   Nat. Biotechnol. 15:629-631(1997).
RN   [2] {ECO:0007829|PDB:2GHW}
RP   X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 1-239, AND DISULFIDE BONDS.
RX   PubMed=16954221; DOI=10.1074/jbc.m603275200;
RA   Hwang W.C., Lin Y., Santelli E., Sui J., Jaroszewski L., Stec B.,
RA   Farzan M., Marasco W.A., Liddington R.C.;
RT   "Structural basis of neutralization by a human anti-severe acute
RT   respiratory syndrome spike protein antibody, 80R.";
RL   J. Biol. Chem. 281:34610-34616(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004370}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
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DR   EMBL; Y13056; CAA73499.1; -; mRNA.
DR   PDB; 2GHW; X-ray; 2.30 A; B/D=1-239.
DR   AlphaFoldDB; Q65ZC9; -.
DR   SMR; Q65ZC9; -.
DR   IntAct; Q65ZC9; 2.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   CDD; cd04981; IgV_H; 1.
DR   CDD; cd04980; IgV_L_kappa; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR23266; IMMUNOGLOBULIN HEAVY CHAIN; 1.
DR   Pfam; PF07686; V-set; 2.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00406; IGv; 2.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:2GHW};
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Immunoglobulin {ECO:0000256|ARBA:ARBA00043265};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT   DOMAIN          1..96
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          134..221
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          116..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        22..96
FT                   /evidence="ECO:0007829|PDB:2GHW"
FT   DISULFID        155..220
FT                   /evidence="ECO:0007829|PDB:2GHW"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAA73499.1"
FT   NON_TER         240
FT                   /evidence="ECO:0000313|EMBL:CAA73499.1"
SQ   SEQUENCE   240 AA;  25569 MW;  FDCFD3645F64B373 CRC64;
     QVQLVQSGGG LVQPGGSLRL SCAASGFTFS SYGMHWVRQA PGKGLEWVAV ISYDGSNKYY
     ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCARDW GDSLDPWGKG TLVTVSSGGG
     GSGGGGSGGG GSDIQMTQSP STLSASIGDR VTITCRASEG IYRWLAWYQQ KPGKAPKLLI
     YKASSLASRA PSRFSGSGSG TDFTLTISSL QPDDFATYYC QQYSNYPLTF GGGTKLEIKR
//