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Protein

Oncostatin-M

Gene

Osm

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processGrowth regulation

Enzyme and pathway databases

ReactomeiR-RNO-6788467 IL-6-type cytokine receptor ligand interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Oncostatin-M
Short name:
OSM
Gene namesi
Name:Osm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1585012 Osm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000040876526 – 208Oncostatin-MBy similarityAdd BLAST183
PropeptideiPRO_0000408766209 – 239By similarityAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 140By similarity
Disulfide bondi72 ↔ 179By similarity

Post-translational modificationi

Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ65Z15
PRIDEiQ65Z15

Expressioni

Tissue specificityi

Widely expressed. Expressed at higher levels in liver, skin and spleen.1 Publication

Gene expression databases

BgeeiENSRNOG00000024390
GenevisibleiQ65Z15 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032548

Structurei

3D structure databases

ProteinModelPortaliQ65Z15
SMRiQ65Z15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LIF/OSM family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWR2 Eukaryota
ENOG41116AW LUCA
GeneTreeiENSGT00390000004850
HOGENOMiHOG000074128
HOVERGENiHBG007867
InParanoidiQ65Z15
KOiK05418
OMAiGYHRFMH
OrthoDBiEOG091G0TZ1
PhylomeDBiQ65Z15
TreeFamiTF338204

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001581 Leukemia_IF/oncostatin
IPR019827 Leukemia_IF/oncostatin_CS
PfamiView protein in Pfam
PF01291 LIF_OSM, 1 hit
SMARTiView protein in SMART
SM00080 LIF_OSM, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00590 LIF_OSM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q65Z15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAQPPPRTL LSLALALLFL SMSWAKRGCS SSSPKLLSQL KSQANITGNT
60 70 80 90 100
ASLLEPYILH QNLNTLTLRA ACTEHPVAFP SEDMLRQLSK PDFLSTVHAT
110 120 130 140 150
LGRVWHQLGA FRQQFPKIQD FPELERARQN IQGIRNNVYC MARLLHPPLE
160 170 180 190 200
IPEPTQADSG TSRPTTTAPG IFQIKIDSCR FLWGYHRFMG SVGRVFEEWG
210 220 230
DGSRRSRRHS PLWAWLKGDH RIRPSRSSQS AMLRSLVPR
Length:239
Mass (Da):27,106
Last modified:October 25, 2004 - v1
Checksum:i78BC63B25A148B16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167521 mRNA Translation: BAD44757.1
RefSeqiNP_001006962.1, NM_001006961.1
UniGeneiRn.127158

Genome annotation databases

EnsembliENSRNOT00000035591; ENSRNOP00000032548; ENSRNOG00000024390
GeneIDi289747
KEGGirno:289747
UCSCiRGD:1585012 rat

Similar proteinsi

Entry informationi

Entry nameiONCM_RAT
AccessioniPrimary (citable) accession number: Q65Z15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: October 25, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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