Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oncostatin-M

Gene

Osm

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Growth regulation

Enzyme and pathway databases

ReactomeiR-RNO-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Oncostatin-M
Short name:
OSM
Gene namesi
Name:Osm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1585012. Osm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 208183Oncostatin-MBy similarityPRO_0000408765Add
BLAST
Propeptidei209 – 23931By similarityPRO_0000408766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 140By similarity
Disulfide bondi72 ↔ 179By similarity

Post-translational modificationi

Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ65Z15.

Expressioni

Tissue specificityi

Widely expressed. Expressed at higher levels in liver, skin and spleen.1 Publication

Gene expression databases

GenevisibleiQ65Z15. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032548.

Structurei

3D structure databases

ProteinModelPortaliQ65Z15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LIF/OSM family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWR2. Eukaryota.
ENOG41116AW. LUCA.
GeneTreeiENSGT00390000004850.
HOGENOMiHOG000074128.
HOVERGENiHBG007867.
InParanoidiQ65Z15.
KOiK05418.
OMAiGYHRFMH.
OrthoDBiEOG7NGQC9.
PhylomeDBiQ65Z15.
TreeFamiTF338204.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q65Z15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAQPPPRTL LSLALALLFL SMSWAKRGCS SSSPKLLSQL KSQANITGNT
60 70 80 90 100
ASLLEPYILH QNLNTLTLRA ACTEHPVAFP SEDMLRQLSK PDFLSTVHAT
110 120 130 140 150
LGRVWHQLGA FRQQFPKIQD FPELERARQN IQGIRNNVYC MARLLHPPLE
160 170 180 190 200
IPEPTQADSG TSRPTTTAPG IFQIKIDSCR FLWGYHRFMG SVGRVFEEWG
210 220 230
DGSRRSRRHS PLWAWLKGDH RIRPSRSSQS AMLRSLVPR
Length:239
Mass (Da):27,106
Last modified:October 25, 2004 - v1
Checksum:i78BC63B25A148B16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167521 mRNA. Translation: BAD44757.1.
RefSeqiNP_001006962.1. NM_001006961.1.
UniGeneiRn.127158.

Genome annotation databases

EnsembliENSRNOT00000035591; ENSRNOP00000032548; ENSRNOG00000024390.
GeneIDi289747.
KEGGirno:289747.
UCSCiRGD:1585012. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167521 mRNA. Translation: BAD44757.1.
RefSeqiNP_001006962.1. NM_001006961.1.
UniGeneiRn.127158.

3D structure databases

ProteinModelPortaliQ65Z15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032548.

Proteomic databases

PaxDbiQ65Z15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035591; ENSRNOP00000032548; ENSRNOG00000024390.
GeneIDi289747.
KEGGirno:289747.
UCSCiRGD:1585012. rat.

Organism-specific databases

CTDi5008.
RGDi1585012. Osm.

Phylogenomic databases

eggNOGiENOG410IWR2. Eukaryota.
ENOG41116AW. LUCA.
GeneTreeiENSGT00390000004850.
HOGENOMiHOG000074128.
HOVERGENiHBG007867.
InParanoidiQ65Z15.
KOiK05418.
OMAiGYHRFMH.
OrthoDBiEOG7NGQC9.
PhylomeDBiQ65Z15.
TreeFamiTF338204.

Enzyme and pathway databases

ReactomeiR-RNO-6788467. IL-6-type cytokine receptor ligand interactions.

Miscellaneous databases

NextBioi630270.
PROiQ65Z15.

Gene expression databases

GenevisibleiQ65Z15. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001581. Leukemia_IF/oncostatin.
IPR019827. Leukemia_IF/oncostatin_CS.
[Graphical view]
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
SMARTiSM00080. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00590. LIF_OSM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes."
    Okaya A., Kitanaka J., Kitanaka N., Satake M., Kim Y., Terada K., Sugiyama T., Takemura M., Fujimoto J., Terada N., Miyajima A., Tsujimura T.
    Am. J. Pathol. 166:709-719(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiONCM_RAT
AccessioniPrimary (citable) accession number: Q65Z15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: October 25, 2004
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.