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Protein

Oncostatin-M-specific receptor subunit beta

Gene

Osmr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Associates with IL31RA to form the IL31 receptor. Binds IL31 and activates STAT1, STAT3 and STAT5. Capable of transducing OSM-specific signaling events (By similarity). The OSM/OSM-R system is pivotal in the differentiation of oval cells into hepatocytes, thereby promoting liver regeneration.By similarity1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Oncostatin-M-specific receptor subunit beta
Alternative name(s):
Interleukin-31 receptor subunit beta
Short name:
IL-31 receptor subunit beta
Short name:
IL-31R subunit beta
Short name:
IL-31R-beta
Short name:
IL-31RB
Gene namesi
Name:Osmr
Synonyms:Osmrb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1302983. Osmr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 738ExtracellularSequence analysisAdd BLAST710
Transmembranei739 – 759HelicalSequence analysisAdd BLAST21
Topological domaini760 – 962CytoplasmicSequence analysisAdd BLAST203

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000025976129 – 962Oncostatin-M-specific receptor subunit betaAdd BLAST934

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi219N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi243 ↔ 253By similarity
Glycosylationi324N-linked (GlcNAc...)Sequence analysis1
Glycosylationi492N-linked (GlcNAc...)Sequence analysis1
Glycosylationi578N-linked (GlcNAc...)Sequence analysis1
Glycosylationi723N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ65Z14.
PRIDEiQ65Z14.

Expressioni

Tissue specificityi

Widely expressed. Expressed at high levels in the liver, skin and spleen. In the liver it is expressed exclusively in the oval cells.1 Publication

Interactioni

Subunit structurei

Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039644.

Structurei

3D structure databases

ProteinModelPortaliQ65Z14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini237 – 332Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini333 – 426Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94
Domaini428 – 527Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST100
Domaini528 – 621Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Domaini623 – 734Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST112

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi413 – 417WSXWS motifBy similarity5
Motifi768 – 776Box 1 motifBy similarity9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity
The box 1 motif is required for JAK interaction and/or activation.By similarity

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFCQ. Eukaryota.
ENOG410Y9XY. LUCA.
HOGENOMiHOG000115294.
HOVERGENiHBG082088.
InParanoidiQ65Z14.
KOiK05057.
PhylomeDBiQ65Z14.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q65Z14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSVVLHQV TFLLAVLSLR TSQSKVLGEP LQLTPEIHTV SLQSALQEAN
60 70 80 90 100
LEWTVPTFSH QELNIVFQIE ISRMRTSNTI WVGNYSTTVK HEETVHWKWT
110 120 130 140 150
SDIPLECATH FIRIRAMVDD AQYPPQSSWS NWSSWKEVNA QVSVPPDTLL
160 170 180 190 200
IFPEDRLLEE GSNVTICLMI GQNLYNVSCK LQEEPIRGEQ LDSHLSLIKL
210 220 230 240 250
NNVVFLNNAG TNINCKAMNG TKNTFGTVLF VSKVLEEPKN FSCETRDFKT
260 270 280 290 300
LNCLWEPGID TTLSWHKQRS QHYTLYESFS GRREVSNHRN SHTWQITEDS
310 320 330 340 350
QETYNFTLTA ENNLRKRSVS ISFNLTHRVH PKAPHDVTLK TVGATKAHMT
360 370 380 390 400
WKVPSRGDYT LLCQVELQCE GEVIHEHNVS VHTSANYLFS DLEPDTEYKA
410 420 430 440 450
CVRCASANHF WKWSDWMQKK FRTPEAAPSE ALDVWRDVRT ENGRHVVTLF
460 470 480 490 500
WKPLLKSQAN GKIISYNIVV ENEANPTESE QYSVRAPALG TNLSLDLHPY
510 520 530 540 550
KIHISANNSA GASPESLVVL SSHSGHEEVH EKTIKGIKNG FNISWEPVSG
560 570 580 590 600
DAIGYVVDWC AHSQTQRCDL QWKNVGPNIT STIITSDAFE PGVRYNFRIF
610 620 630 640 650
ERSVEENVRL VEKQRGYTQE LAPSVNPGVT IHNLTPNSFS LKWQDYASDF
660 670 680 690 700
QSGFIKGYLV YLKSKELQCN PNWERTVLSD KSVLCKYDVD DPETKTLTVE
710 720 730 740 750
NLRPESLYEF LVTPYTSAGQ GPNETYTKVT TPDVRSHMLL QIILPMTLGV
760 770 780 790 800
FLSIIVCYWK SQWVKEKCYP DIPNPYKSSI LSLIKSKKNP HLIMNVKDCI
810 820 830 840 850
PDVLEVINKA EGSKTQCVGS GKLHTEDVPT KPPLVPTEKD SSGPMPFVFL
860 870 880 890 900
ENFTYDQSAF DSGSHGFIPG PLKNTPHQLG LLAPPNKLQN VLENDYMKSL
910 920 930 940 950
VESPTEETSL IYVSQLASPI CGDKDSLVTN PPMPVHGSEY KKQMALPGSL
960
TSASLKENNL TS
Length:962
Mass (Da):108,625
Last modified:October 25, 2004 - v1
Checksum:iA7A15FED59A6E21A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167522 mRNA. Translation: BAD44758.1.
RefSeqiNP_001005384.1. NM_001005384.1.
UniGeneiRn.92110.

Genome annotation databases

GeneIDi310132.
KEGGirno:310132.
UCSCiRGD:1302983. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB167522 mRNA. Translation: BAD44758.1.
RefSeqiNP_001005384.1. NM_001005384.1.
UniGeneiRn.92110.

3D structure databases

ProteinModelPortaliQ65Z14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039644.

Proteomic databases

PaxDbiQ65Z14.
PRIDEiQ65Z14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi310132.
KEGGirno:310132.
UCSCiRGD:1302983. rat.

Organism-specific databases

CTDi9180.
RGDi1302983. Osmr.

Phylogenomic databases

eggNOGiENOG410IFCQ. Eukaryota.
ENOG410Y9XY. LUCA.
HOGENOMiHOG000115294.
HOVERGENiHBG082088.
InParanoidiQ65Z14.
KOiK05057.
PhylomeDBiQ65Z14.

Miscellaneous databases

PROiQ65Z14.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSMR_RAT
AccessioniPrimary (citable) accession number: Q65Z14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 25, 2004
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.