Q65WJ5 (ARAA_MANSM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	MS0058

Organism

Mannheimia succiniciproducens (strain MBEL55E) [Complete proteome] [HAMAP]

Taxonomic identifier

221988 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Basfia

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	L-arabinose isomerase HAMAP MF_00519		PRO_0000259340
Sites
	Metal binding	305	1	Manganese By similarity
	Metal binding	332	1	Manganese By similarity
	Metal binding	349	1	Manganese By similarity
	Metal binding	448	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q65WJ5 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 285EE475CA89D6A1	FASTA	495	55,918
	10 20 30 40 50 60 MEFLKKLEVW FVVGSQDLYG DEALKQVNAN AEQITRYLND QNPFIQIKLK PLATTPEDIL 70 80 90 100 110 120 SLCQAANYEE NCVGVIAWMH TFSPAKMWIG GLTRLNKPLL QFHTQLNKNI PWNEIDMDYM 130 140 150 160 170 180 NLHQTAHGDR EFGFMVSRFR KPRTIVVGHW QSESVKQKLD RWMRVLAAIY DQQHLKVARF 190 200 210 220 230 240 GDNMREVAVT EGDKVEAQIK FGYSVNGYGL YQLVNSINTV NDEDITALVK EYEASYQLAD 250 260 270 280 290 300 SLKDGGEKRQ SLIDSARIEL GLKAFLDKGG FKAFTDTFQN LAGIKQLPGL PVQRLMAQGY 310 320 330 340 350 360 GFGAEGDWKT AALVRAIKVM SYGLPNGCSF MEDYTYNLDD NNEIVLGAHM LEVCPSIANN 370 380 390 400 410 420 KPILDIKPLG IGGKEDPARL IFTSKSGKAT ASTIVDLGNR FRMITADMQA VDKPQDMPNL 430 440 450 460 470 480 PVGHAFWKLE PNFDIGTQAW ILSGGAHHNV FSLDIDADML RTFAEYFDIE FIHINVKTEL 490 PNLKNELRWN EAAYK

References

[1]

"The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens." Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J. Nat. Biotechnol. 22:1275-1281(2004) [PubMed: 15378067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MBEL55E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016827 Genomic DNA. Translation: AAU36665.1.
RefSeq	YP_087250.1. NC_006300.1.
3D structure databases
HSSP	HSSP built from PDB template 2AJT based on UniProtKB P08202.
ProteinModelPortal	Q65WJ5.
SMR	Q65WJ5. Positions 1-495.
ModBase	Search...
Protein-protein interaction databases
STRING	Q65WJ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3075854.
GenomeReviews	Gene locus MS0058 in contig AE016827_GR.
KEGG	msu:MS0058.
NMPDR	fig|221988.1.peg.56.
PATRIC	22443563. VBIManSuc86752_0053.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2160.
HOGENOM	HBG297198.
OMA	EVCPTIA.
PhylomeDB	Q65WJ5.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	MSUC221988:MS0058-MONOMER.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_MANSM

Accession

Primary (citable) accession number: Q65WJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 25, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program