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Q65W08 (PGK_MANSM) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:MS0245
OrganismMannheimia succiniciproducens (strain MBEL55E) [Complete proteome] [HAMAP]
Taxonomic identifier221988 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000058011

Regions

Nucleotide binding342 – 3454ATP By similarity
Region21 – 233Substrate binding By similarity
Region59 – 624Substrate binding By similarity

Sites

Binding site361Substrate By similarity
Binding site1121Substrate By similarity
Binding site1451Substrate By similarity
Binding site1961ATP By similarity
Binding site3131ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q65W08 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 91A09D448F88E4E7

FASTA38941,241
        10         20         30         40         50         60 
MSVIKMTDLD LAGKRLFIRA DLNVPVKDGK VTSDARIRAT IPTLKLALEK GAKVMVTSHL 

        70         80         90        100        110        120 
GRPTEGEFKP EDSLQPVVDY LKDAGFNVRL AQNYLDGVEV NEGEIVVLEN VRINKGEKKN 

       130        140        150        160        170        180 
DPELGKKYAA LCDVFVMDAF GTAHRAQAST YGVAEYAPVA CAGPLLAAEL DALGKALKEP 

       190        200        210        220        230        240 
QRPMLAIVGG SKVSTKLTVL DSLSKIADQL IVGGGIANTF IAAEGHNVGK SLYEEDLIPE 

       250        260        270        280        290        300 
AKRLAAATNI PVPVDVRVGT EFSENAPATE KSVTEVQADE SIFDIGDKSA EELAKIIKSA 

       310        320        330        340        350        360 
KTILWNGPVG VFEFPNFRKG TEVISNAIAE ATANGAFSIA GGGDTLAAID LFGIKDKISY 

       370        380 
ISTGGGAFLE FVEGKVLPAV EILEKRANG 

« Hide

References

[1]"The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MBEL55E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016827 Genomic DNA. Translation: AAU36852.1.
RefSeqYP_087437.1. NC_006300.1.

3D structure databases

ProteinModelPortalQ65W08.
SMRQ65W08. Positions 2-387.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING221988.MS0245.

Proteomic databases

PRIDEQ65W08.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU36852; AAU36852; MS0245.
GeneID3076778.
KEGGmsu:MS0245.
PATRIC22443916. VBIManSuc86752_0225.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMAAGHPVGK.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycBMAN221988:GHGM-249-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGK_MANSM
AccessionPrimary (citable) accession number: Q65W08
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways