ID   Q65VX6_MANSM            Unreviewed;       834 AA.
AC   Q65VX6;
DT   25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE   AltName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE   AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN   Name=cyaA {ECO:0000313|EMBL:AAU36884.1};
GN   OrderedLocusNames=MS0277 {ECO:0000313|EMBL:AAU36884.1};
OS   Mannheimia succiniciproducens (strain MBEL55E).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Basfia.
OX   NCBI_TaxID=221988 {ECO:0000313|EMBL:AAU36884.1, ECO:0000313|Proteomes:UP000000607};
RN   [1] {ECO:0000313|EMBL:AAU36884.1, ECO:0000313|Proteomes:UP000000607}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBEL55E {ECO:0000313|EMBL:AAU36884.1,
RC   ECO:0000313|Proteomes:UP000000607};
RX   PubMed=15378067; DOI=10.1038/nbt1010;
RA   Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H.,
RA   Jeong H., Hur C.G., Kim J.J.;
RT   "The genome sequence of the capnophilic rumen bacterium Mannheimia
RT   succiniciproducens.";
RL   Nat. Biotechnol. 22:1275-1281(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
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DR   EMBL; AE016827; AAU36884.1; -; Genomic_DNA.
DR   RefSeq; WP_011199459.1; NC_006300.1.
DR   AlphaFoldDB; Q65VX6; -.
DR   STRING; 221988.MS0277; -.
DR   KEGG; msu:MS0277; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   OrthoDB; 5571448at2; -.
DR   Proteomes; UP000000607; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          5..207
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   834 AA;  97000 MW;  AC40E37B61446F8B CRC64;
     MKYDLQFAKK QVDDLHRLRV ERVLQGSTAD FQHVFQLIAL LLHLNHPALP GYVTDAPAGV
     AHFKLSDYQK NFLAQQFPTG FDFVRLEQES NAHQQEKTPI YGVYVMGSIA SISQTAKSDL
     DTWVCHSPDL TPYALNKLQQ KTQLLKIWAK KFNTDITLFL MDEFYFNHYR YSNTLSVENC
     GSAQHMLLLD EFYRSAIRLA GKPLLWLHLN VENEADYGKE VQRLQQTKQI NRADWIDFGG
     LGAFSANEYF GASLWQLYKG IDSPYKSVLK IVLLESYSQE YPNAKLISMQ FKQQLFNLKP
     VKEQCFDAYL AMLERVTEYL TKLKDEKRLD FIRRCFYIKV TETVRERPLA PWRAKILKNL
     TAQWGWSEET IKHLNRIHTW KIRSVRETHN KLIRVLMLSY RNLVNFARKH NVNASIAPQD
     ISILTRKLYT AFEVLPGKVT LMNPQLALDL SEKNLTFIEV TEEHGVKPGW YVVNQMPSVV
     YPSQNRYIEY NPILIKLIAW TYFNGLLTSK TKVHISSTHV DIEKINQCIT DLRVSFPVKA
     SPPTDEELTH PCEIRSLAVM INLTKDPTPY SDINRTEIQQ SDLFSLDGEN ESLIGSVDLL
     YRNKWNEIKT LHYEGDKAML SALKVLSNKI HRGSGVPESV NVFCYNQYYQ EEISELVVGL
     LNKCISIQLG TTQLPMSSVP RMTGKNWKLF FEEHDATLHQ PQTEPVFISQ VIAEQKQVKV
     KRNQPYKHLL NYPRQIDSFA SEGFLQFFFE DNEDETFNVY ILDENNRLEI YRQCDGSKEQ
     KIREISQIYN LSGSDQNDNH YKIIKRDFNY PQFYQLKHQQ KGILILPFSG SCMV
//