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Q65VR5

- SYL_MANSM

UniProt

Q65VR5 - SYL_MANSM

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Protein
Leucine--tRNA ligase
Gene
leuS, MS0338
Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBMAN221988:GHGM-344-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:MS0338
OrganismiMannheimia succiniciproducens (strain MBEL55E)
Taxonomic identifieri221988 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
ProteomesiUP000000607: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Leucine--tRNA ligaseUniRule annotation
PRO_0000152040Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi221988.MS0338.

Structurei

3D structure databases

ProteinModelPortaliQ65VR5.
SMRiQ65VR5. Positions 228-413.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi619 – 6235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q65VR5-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYRPDLL EQEVQKYWQN NQTFKAVKDS SKEKYYCLSM FPYPSGRLHM    50
GHVRNYTIAD VVSRYQRMNG KNVLQPVGWD AFGLPAEGAA VKNKTAPAKW 100
TYENIDYMKN QLKMLGFSYD WDREIATCKP EYYKWEQWFF TELYKKGLVY 150
KKTSVVNWCP NDETVLANEQ VHEGCCWRCD TPVEQKEIPQ WFIKITDYAE 200
QLLSGLDTLP EWPDMVKTMQ RNWIGRSEGV EITFKIENSD ETVAVYTTRP 250
DTFYGVSYMA VAAGHPLAEK AAQNNAELAR FIQECKNTKV AEAELATMEK 300
KGMATGINAI HPITGKPVPV WVANFVLMHY GTGAVMAVPA HDQRDFEFAT 350
KYGLPIKQVI APMNGEEIDL TKAAFTEHGK LVNSAEFDGL DFEAAFNGIA 400
DKLEKMGVGK RQVNYRLRDW GVSRQRYWGA PIPMLTLENG DVVPAPLQDL 450
PIVLPEDVVM DGVKSPIKAD PDWAKTSYNG QPALKETDTF DTFMESSWYY 500
ARYTSPQYHE GMLDSDEANY WLPVDQYIGG IEHATMHLLY FRFFHKLLRD 550
AGLVSTDEPT KKLLCQGMVL ADAFYYTSPT NERIWVSPTK VMLERDEKGR 600
ILKATDDEGH ELVHAGMTKM SKSKNNGIDP QEMVEKYGAD TVRLFMMFAS 650
PAEMTLEWQE SGVEGAKRFL GRLWNLVFEY NKNPVKTAPN PTALSSAQKA 700
LRRDVHKTIA KVSDDIGRRQ TFNTAIAAIM ELMNKLTRAP LTDEQDRAVM 750
GEALSAVVRM LYPITPHICF QLWKDLGNED IIDFAPWVQA DEAAMIDDEK 800
LVVVQVNGKV RGKITVPADM AEEEIKRVAL AEENVQKFLD GLNIVKVIYV 850
PGKLLSFVAK 860
Length:860
Mass (Da):97,814
Last modified:October 25, 2004 - v1
Checksum:iA5D49243B05C04C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016827 Genomic DNA. Translation: AAU36945.1.
RefSeqiWP_011199520.1. NC_006300.1.
YP_087530.1. NC_006300.1.

Genome annotation databases

EnsemblBacteriaiAAU36945; AAU36945; MS0338.
GeneIDi3076196.
KEGGimsu:MS0338.
PATRICi22444096. VBIManSuc86752_0313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016827 Genomic DNA. Translation: AAU36945.1 .
RefSeqi WP_011199520.1. NC_006300.1.
YP_087530.1. NC_006300.1.

3D structure databases

ProteinModelPortali Q65VR5.
SMRi Q65VR5. Positions 228-413.
ModBasei Search...

Protein-protein interaction databases

STRINGi 221988.MS0338.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU36945 ; AAU36945 ; MS0338 .
GeneIDi 3076196.
KEGGi msu:MS0338.
PATRICi 22444096. VBIManSuc86752_0313.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BMAN221988:GHGM-344-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens."
    Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H., Jeong H., Hur C.G., Kim J.J.
    Nat. Biotechnol. 22:1275-1281(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MBEL55E.

Entry informationi

Entry nameiSYL_MANSM
AccessioniPrimary (citable) accession number: Q65VR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 25, 2004
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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