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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Mannheimia succiniciproducens (strain MBEL55E)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62SubstrateUniRule annotation1
Binding sitei70SubstrateUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Sitei175Important for catalytic activityUniRule annotation1
Active sitei177Proton donor/acceptorUniRule annotation1
Active sitei249NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:MS0396
OrganismiMannheimia succiniciproducens (strain MBEL55E)
Taxonomic identifieri221988 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeBasfia
Proteomesi
  • UP000000607 Componenti: Chromosome

Subcellular locationi

Q65VK7:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002349151 – 347Beta-hexosaminidaseAdd BLAST347

Interactioni

Protein-protein interaction databases

STRINGi221988.MS0396.

Structurei

3D structure databases

ProteinModelPortaliQ65VK7.
SMRiQ65VK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 165Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QPA. Bacteria.
COG1472. LUCA.
HOGENOMiHOG000248526.
KOiK01207.
OMAiHKETPRD.
OrthoDBiPOG091H039J.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ. 1 hit.
InterProiView protein in InterPro
IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR036962. Glyco_hydro_3_N_sf.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00933. Glyco_hydro_3. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00775. GLYCOSYL_HYDROL_F3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q65VK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLLIDLKG QELLAEEAEL LAHPLVAGLI LFTRNFYDRS QIQALIKDIR
60 70 80 90 100
RRVKKPLLIT VDQEGGRVQR FREGFTQLPA MQSFAAMISD PALQLTTAKE
110 120 130 140 150
AGWLMAAEMT ALDIDLSFAP VLDLGHECKA IGDRSFCEEV EPAVRLASAF
160 170 180 190 200
IDGMHQAGMA TTGKHFPGHG HVLADSHLET PYDERPSAVI FERDIQPFQQ
210 220 230 240 250
LIAQNKLDAV MPAHVIYRHC DSQPASGSKY WLQDILRQKL GFDGTVFSDD
260 270 280 290 300
LGMKGAGFMG DFVARSEKAL SAGCDLLLLC NEPEGVVQVL DNLKLEENPP
310 320 330 340
HFAARQRRLQ SLFKKKAFSW NELTKTRRWL ENSKKLTALQ QSWLDSK
Length:347
Mass (Da):38,847
Last modified:October 25, 2004 - v1
Checksum:iC75099A6C2D8DAA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016827 Genomic DNA. Translation: AAU37003.1.
RefSeqiWP_011199578.1. NC_006300.1.

Genome annotation databases

EnsemblBacteriaiAAU37003; AAU37003; MS0396.
KEGGimsu:MS0396.

Similar proteinsi

Entry informationi

Entry nameiNAGZ_MANSM
AccessioniPrimary (citable) accession number: Q65VK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 25, 2004
Last modified: October 25, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families